Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection

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dc.contributor.authorRadwanska, Magdalenaen_ZA
dc.contributor.authorCutler, Antony Jen_ZA
dc.contributor.authorHoving, J Claireen_ZA
dc.contributor.authorMagez, Stefanen_ZA
dc.contributor.authorHolscher, Christophen_ZA
dc.contributor.authorBohms, Andreasen_ZA
dc.contributor.authorArendse, Bereniceen_ZA
dc.contributor.authorKirsch, Richarden_ZA
dc.contributor.authorHunig, Thomasen_ZA
dc.contributor.authorAlexander, Jamesen_ZA
dc.date.accessioned2015-11-23T12:35:24Z
dc.date.available2015-11-23T12:35:24Z
dc.date.issued2007en_ZA
dc.description.abstractAuthor Summary Leishmaniasis is a disease induced by a protozoan parasite and transmitted by the sandfly. Several forms of infection are identified, and the different diseases have wide-ranging symptoms from localized cutaneous sores to visceral disease affecting many internal organs. Animal models of human cutaneous leishmaniasis have been established in which disease is induced by infecting mice subcutaneously with Leishmania major. Different strains of inbred mice have been found to be susceptible or resistant to L. major infection. "Healer" C57BL/6 mice control infection with transient lesion development. The protective response to infection in this strain is dominated by type 1 cytokines inducing parasite killing by nitric oxide. Conversely, "nonhealer" BALB/c mice are unable to control infection and develop nonhealing lesions associated with a dominant type 2 immune response driven by cytokines IL-4 and IL-13. However, mice deficient in IL-4/IL-13 signaling are not protected against development of cutaneous leishmaniasis. Here we describe a BALB/c mouse where the ability to polarize to a dominant type 2 response is removed by cell-specific deletion of the receptor for IL-4/IL-13 on CD4 + T cells. These mice are resistant to L. major infection similar to C57BL/6 mice, which highlights the role of T helper 2 cells in driving susceptibility and the protective role of IL-4/IL-13 signaling in non-CD4 + T cells in BALB/c mice.en_ZA
dc.identifier.apacitationRadwanska, M., Cutler, A. J., Hoving, J. C., Magez, S., Holscher, C., Bohms, A., ... Alexander, J. (2007). Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection. <i>PLoS One</i>, http://hdl.handle.net/11427/15327en_ZA
dc.identifier.chicagocitationRadwanska, Magdalena, Antony J Cutler, J Claire Hoving, Stefan Magez, Christoph Holscher, Andreas Bohms, Berenice Arendse, Richard Kirsch, Thomas Hunig, and James Alexander "Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection." <i>PLoS One</i> (2007) http://hdl.handle.net/11427/15327en_ZA
dc.identifier.citationRadwanska, M., Cutler, A. J., Hoving, J. C., Magez, S., Holscher, C., Bohms, A., ... & Brombacher, F. (2007). Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection. PLoS Pathog, 3(5), e68. doi:10.1371/journal.ppat.0030068en_ZA
dc.identifier.ris TY - Journal Article AU - Radwanska, Magdalena AU - Cutler, Antony J AU - Hoving, J Claire AU - Magez, Stefan AU - Holscher, Christoph AU - Bohms, Andreas AU - Arendse, Berenice AU - Kirsch, Richard AU - Hunig, Thomas AU - Alexander, James AB - Author Summary Leishmaniasis is a disease induced by a protozoan parasite and transmitted by the sandfly. Several forms of infection are identified, and the different diseases have wide-ranging symptoms from localized cutaneous sores to visceral disease affecting many internal organs. Animal models of human cutaneous leishmaniasis have been established in which disease is induced by infecting mice subcutaneously with Leishmania major. Different strains of inbred mice have been found to be susceptible or resistant to L. major infection. "Healer" C57BL/6 mice control infection with transient lesion development. The protective response to infection in this strain is dominated by type 1 cytokines inducing parasite killing by nitric oxide. Conversely, "nonhealer" BALB/c mice are unable to control infection and develop nonhealing lesions associated with a dominant type 2 immune response driven by cytokines IL-4 and IL-13. However, mice deficient in IL-4/IL-13 signaling are not protected against development of cutaneous leishmaniasis. Here we describe a BALB/c mouse where the ability to polarize to a dominant type 2 response is removed by cell-specific deletion of the receptor for IL-4/IL-13 on CD4 + T cells. These mice are resistant to L. major infection similar to C57BL/6 mice, which highlights the role of T helper 2 cells in driving susceptibility and the protective role of IL-4/IL-13 signaling in non-CD4 + T cells in BALB/c mice. DA - 2007 DB - OpenUCT DO - 10.1371/journal.ppat.0030068 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2007 T1 - Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection TI - Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection UR - http://hdl.handle.net/11427/15327 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15327
dc.identifier.urihttp://dx.doi.org/10.1371/journal.ppat.0030068
dc.identifier.vancouvercitationRadwanska M, Cutler AJ, Hoving JC, Magez S, Holscher C, Bohms A, et al. Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection. PLoS One. 2007; http://hdl.handle.net/11427/15327.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2007 Radwanska et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plospathogensen_ZA
dc.subject.otherT cellsen_ZA
dc.subject.otherLeishmania majoren_ZA
dc.subject.otherMacrophagesen_ZA
dc.subject.otherMouse modelsen_ZA
dc.subject.otherParasitic diseasesen_ZA
dc.subject.otherImmune responseen_ZA
dc.subject.otherInfectious disease controlen_ZA
dc.subject.otherCytokinesen_ZA
dc.titleDeletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infectionen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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