Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: a systematic review and meta-analysis

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dc.contributor.authorIbeneme, Sam C
dc.contributor.authorUwakwe, Victor C
dc.contributor.authorMyezwa, Hellen
dc.contributor.authorIrem, Franklin O
dc.contributor.authorEzenwankwo, Fortune E
dc.contributor.authorAjidahun, Tunde A
dc.contributor.authorEzuma, Amarachi D
dc.contributor.authorOkonkwo, Uchenna P
dc.contributor.authorFortwengel, Gerhard
dc.date.accessioned2022-07-13T12:41:40Z
dc.date.available2022-07-13T12:41:40Z
dc.date.issued2022-05-16
dc.date.updated2022-05-22T03:24:56Z
dc.description.abstractBackground Symptoms of depression are prevalent in people living with human immune deficiency virus/acquired immune deficiency syndrome (PLWHA), and worsened by lack of physical activity/exercises, leading to restriction in social participation/functioning. This raises the question: what is the extent to which physical exercise training affected, symptoms of depression, physical activity level (PAL) and social participation in PLWHA compared to other forms of intervention, usual care, or no treatment controls? Method Eight databases were searched up to July 2020, according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocol. Only randomised controlled trials involving adults who were either on HAART/HAART-naïve and reported in the English language, were included. Two independent reviewers determined the eligibility of the studies, extracted data, assessed their quality, and risk of bias using the Physiotherapy Evidence Database (PEDro) tool. Standardised mean difference (SMD) was used as summary statistics for the mean primary outcome (symptoms of depression) and secondary outcomes (PAL and social participation) since different measuring tools/units were used across the included studies. Summary estimates of effects were determined using a random-effects model (I2). Results Thirteen studies met the inclusion criteria with 779 participants (n = 596 participants at study completion) randomised into the study groups, comprising 378 males, 310 females and 91 participants with undisclosed gender, and with an age range of 18–86 years. Across the studies, aerobic or aerobic plus resistance exercises were performed 2–3 times/week, at 40–60 min/session, and for between 6-24 weeks, and the risk of bias vary from high to low. Comparing the intervention to control groups showed significant difference in the symptoms of depression (SMD = − 0.74, 95% confidence interval (CI) − 1.01, − 0.48, p ≤ 0.0002; I2 = 47%; 5 studies; 205 participants) unlike PAL (SMD = 0.98, 95% CI − 0.25, 2.17, p = 0.11; I2 = 82%; 2 studies; 62 participants) and social participation (SMD = 0.04, 95% CI − 0.65, 0.73, p = 0.91; I2 = 90%; 6 studies; 373 participants). Conclusion Physical exercise training could have an antidepressant-like effect in PLWHA but did not affect PAL and social participation. However, the high heterogeneity in the included studies, implies that adequately powered randomised controlled trials with clinical/methodological similarity are required in future studies. Trail Registration number INPLASY202040048.en_US
dc.identifier.apacitationIbeneme, S. C., Uwakwe, V. C., Myezwa, H., Irem, F. O., Ezenwankwo, F. E., Ajidahun, T. A., ... Fortwengel, G. (2022). Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: a systematic review and meta-analysis. <i>BMC Infectious Diseases</i>, 22(1), 469. http://hdl.handle.net/11427/36647en_ZA
dc.identifier.chicagocitationIbeneme, Sam C, Victor C Uwakwe, Hellen Myezwa, Franklin O Irem, Fortune E Ezenwankwo, Tunde A Ajidahun, Amarachi D Ezuma, Uchenna P Okonkwo, and Gerhard Fortwengel "Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: a systematic review and meta-analysis." <i>BMC Infectious Diseases</i> 22, 1. (2022): 469. http://hdl.handle.net/11427/36647en_ZA
dc.identifier.citationIbeneme, S.C., Uwakwe, V.C., Myezwa, H., Irem, F.O., Ezenwankwo, F.E., Ajidahun, T.A., Ezuma, A.D. & Okonkwo, U.P. et al. 2022. Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: a systematic review and meta-analysis. <i>BMC Infectious Diseases.</i> 22(1):469. http://hdl.handle.net/11427/36647en_ZA
dc.identifier.ris TY - Journal Article AU - Ibeneme, Sam C AU - Uwakwe, Victor C AU - Myezwa, Hellen AU - Irem, Franklin O AU - Ezenwankwo, Fortune E AU - Ajidahun, Tunde A AU - Ezuma, Amarachi D AU - Okonkwo, Uchenna P AU - Fortwengel, Gerhard AB - Background Symptoms of depression are prevalent in people living with human immune deficiency virus/acquired immune deficiency syndrome (PLWHA), and worsened by lack of physical activity/exercises, leading to restriction in social participation/functioning. This raises the question: what is the extent to which physical exercise training affected, symptoms of depression, physical activity level (PAL) and social participation in PLWHA compared to other forms of intervention, usual care, or no treatment controls? Method Eight databases were searched up to July 2020, according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocol. Only randomised controlled trials involving adults who were either on HAART/HAART-naïve and reported in the English language, were included. Two independent reviewers determined the eligibility of the studies, extracted data, assessed their quality, and risk of bias using the Physiotherapy Evidence Database (PEDro) tool. Standardised mean difference (SMD) was used as summary statistics for the mean primary outcome (symptoms of depression) and secondary outcomes (PAL and social participation) since different measuring tools/units were used across the included studies. Summary estimates of effects were determined using a random-effects model (I2). Results Thirteen studies met the inclusion criteria with 779 participants (n = 596 participants at study completion) randomised into the study groups, comprising 378 males, 310 females and 91 participants with undisclosed gender, and with an age range of 18–86 years. Across the studies, aerobic or aerobic plus resistance exercises were performed 2–3 times/week, at 40–60 min/session, and for between 6-24 weeks, and the risk of bias vary from high to low. Comparing the intervention to control groups showed significant difference in the symptoms of depression (SMD = − 0.74, 95% confidence interval (CI) − 1.01, − 0.48, p ≤ 0.0002; I2 = 47%; 5 studies; 205 participants) unlike PAL (SMD = 0.98, 95% CI − 0.25, 2.17, p = 0.11; I2 = 82%; 2 studies; 62 participants) and social participation (SMD = 0.04, 95% CI − 0.65, 0.73, p = 0.91; I2 = 90%; 6 studies; 373 participants). Conclusion Physical exercise training could have an antidepressant-like effect in PLWHA but did not affect PAL and social participation. However, the high heterogeneity in the included studies, implies that adequately powered randomised controlled trials with clinical/methodological similarity are required in future studies. Trail Registration number INPLASY202040048. DA - 2022-05-16 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - BMC Infectious Diseases KW - Exercise training KW - Mental health KW - Physical activity level KW - Social participation KW - HIV/AIDS LK - https://open.uct.ac.za PY - 2022 T1 - Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: a systematic review and meta-analysis TI - Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: a systematic review and meta-analysis UR - http://hdl.handle.net/11427/36647 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s12879-022-07145-4
dc.identifier.urihttp://hdl.handle.net/11427/36647
dc.identifier.vancouvercitationIbeneme SC, Uwakwe VC, Myezwa H, Irem FO, Ezenwankwo FE, Ajidahun TA, et al. Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: a systematic review and meta-analysis. BMC Infectious Diseases. 2022;22(1):469. http://hdl.handle.net/11427/36647.en_ZA
dc.language.isoenen_US
dc.language.rfc3066en
dc.publisher.departmentMRC/UCT RU for Exercise and Sport Medicineen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceBMC Infectious Diseasesen_US
dc.source.journalissue1en_US
dc.source.journalvolume22en_US
dc.source.pagination469en_US
dc.source.urihttps://bmcinfectdis.biomedcentral.com/
dc.subjectExercise trainingen_US
dc.subjectMental healthen_US
dc.subjectPhysical activity levelen_US
dc.subjectSocial participationen_US
dc.subjectHIV/AIDSen_US
dc.titleImpact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: a systematic review and meta-analysisen_US
dc.typeJournal Articleen_US
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