Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment

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dc.contributor.advisorEgan, Timothy Jen_ZA
dc.contributor.advisorKoch, Klausen_ZA
dc.contributor.authorSwan, Paul Lombarden_ZA
dc.date.accessioned2014-11-22T05:52:48Z
dc.date.available2014-11-22T05:52:48Z
dc.date.issued2002en_ZA
dc.descriptionIncludes bibliography.en_ZA
dc.description.abstractTo establish their potential as a template for novel anti-malarial drugs, a series of planinum (II) complexes were synthesised, their association with haematin determined in 40 aqueous DMSO, pH 7.4 at 25°C and their ability to inhibit the formation of β-haematin (synthetic malaria pigment) was investigated. The compounds synthesised and investigated contained a platinum (II) ion coordinated to acylthiourea and diimine ligands. The diimines used included both substituted and unsubstituted 2,2’-bipyridines and 1,10-phenanthrolines. 2-phenyl pyridine was also utilised as a ligand. It has been shown that the uncoordinated planar ligands interact weakly with haematin with a log K in the range of 1.9 and 3.3 while the twisted or more sterically hindered ligands show no observable association with porphyrin. A series of complexes having platinum coordinated which was reflected in association constant log K values in the range of 4.8 to 5.8. Using a 1,10-phenanthroline ligand in place of a 2,2-bipyridine ligand increased the association constant of the platinum complex, resulting in this series of complexes having log K values in the range of 5.8 to 6.2. It has been shown that when platinum (II) is coordinated to diimines, it is the electron withdrawing properties of the metal which result in the strong association between the diimine containing complex and haematin. Finally both the complex containing platinum cis to two acylthiourea ligands as well as a platinum complex containing 2-phenyl pyridine were shown to have no observable interaction with haematin.en_ZA
dc.identifier.apacitationSwan, P. L. (2002). <i>Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/9782en_ZA
dc.identifier.chicagocitationSwan, Paul Lombard. <i>"Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2002. http://hdl.handle.net/11427/9782en_ZA
dc.identifier.citationSwan, P. 2002. Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Swan, Paul Lombard AB - To establish their potential as a template for novel anti-malarial drugs, a series of planinum (II) complexes were synthesised, their association with haematin determined in 40 aqueous DMSO, pH 7.4 at 25°C and their ability to inhibit the formation of β-haematin (synthetic malaria pigment) was investigated. The compounds synthesised and investigated contained a platinum (II) ion coordinated to acylthiourea and diimine ligands. The diimines used included both substituted and unsubstituted 2,2’-bipyridines and 1,10-phenanthrolines. 2-phenyl pyridine was also utilised as a ligand. It has been shown that the uncoordinated planar ligands interact weakly with haematin with a log K in the range of 1.9 and 3.3 while the twisted or more sterically hindered ligands show no observable association with porphyrin. A series of complexes having platinum coordinated which was reflected in association constant log K values in the range of 4.8 to 5.8. Using a 1,10-phenanthroline ligand in place of a 2,2-bipyridine ligand increased the association constant of the platinum complex, resulting in this series of complexes having log K values in the range of 5.8 to 6.2. It has been shown that when platinum (II) is coordinated to diimines, it is the electron withdrawing properties of the metal which result in the strong association between the diimine containing complex and haematin. Finally both the complex containing platinum cis to two acylthiourea ligands as well as a platinum complex containing 2-phenyl pyridine were shown to have no observable interaction with haematin. DA - 2002 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2002 T1 - Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment TI - Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment UR - http://hdl.handle.net/11427/9782 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/9782
dc.identifier.vancouvercitationSwan PL. Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2002 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/9782en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleSynthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigmenten_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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