The associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition

dc.contributor.authorBaghdan, Danny
dc.contributor.authorDugas, Lara R
dc.contributor.authorChoo-Kang, Candice
dc.contributor.authorPlange-Rhule, Jacob
dc.contributor.authorBovet, Pascal
dc.contributor.authorViswanathan, Bharathi
dc.contributor.authorForrester, Terrence
dc.contributor.authorLambert, Estelle V
dc.contributor.authorRiesen, Walter
dc.contributor.authorKorte, Wolfgang
dc.contributor.authorChoudhry, Mashkoor A
dc.contributor.authorLuke, Amy
dc.date.accessioned2021-12-06T08:44:17Z
dc.date.available2021-12-06T08:44:17Z
dc.date.issued2021-12-04
dc.date.updated2021-12-05T04:12:06Z
dc.description.abstractBackground Cardiometabolic (CM) risk affects approximately 25% of adults globally, and is diagnosed by meeting 3 out of 5 of the following CM risk factors: elevated blood pressure, high triglycerides, elevated blood sugar, low high-density lipoprotein (HDL) level, and abdominal obesity. Adults with CM risk are approximately 22% more likely to have higher mortality rates, and alcohol consumption may be associated with higher CM risk. While previous studies have investigated this potential connection, the majority of them did not include African-origin adults. Therefore, the study aimed to explore the association between alcohol intake and CM risk in 5 African-origin cohorts, spanning the epidemiologic transition in Ghana, South Africa, Jamaica, Seychelles and the United States of America. Methods Measurements included clinical measures for CM risk and self-reported alcohol consumption. Each participant was categorized into one of three drinking categories: non-drinker, light drinker (1–3 drinks daily for men and 1–2 drinks daily for women) and heavy drinker (4 or more drinks every day for men and 3 or more drinks per day for women). Using non-drinker status as the reference, the association between alcohol consumption status and prevalence of each of the five CM risk factors and overall elevated CM risk (having 3 out of 5 risk factors) was explored, adjusting for site, age and sex. Associations were explored using logistic regression and significance was determined using odds ratios (OR) and 95% confidence intervals. Results Neither light nor heavy drinking was associated with increased odds for having higher CM risk compared to nondrinkers (OR = 1.05, p = 0.792 and OR = 1.11, p = 0.489, respectively). However, light drinking was associated with lower odds for having low high density lipoproteins (HDL) cholesterol (OR = 0.69, p = 0.002) and increased risk for high triglycerides (OR = 1.48, p = 0.030). Heavy drinking was associated with elevated blood pressure (OR = 1.59, p = 0.002), high triglycerides (OR = 1.73, p = 0.006) and decreased risk of low HDL-cholesterol (OR = 0.621, p < 0.0005). Finally, country-specific analyses indicated that the relationship between heavy drinking and elevated CM risk varied widely across sites. Conclusion While several CM risk factors were associated with alcohol consumption, the associations were inconsistent and varied widely across five international cohorts of African-origin. Future studies should focus on understanding the individual site-related effects.en_US
dc.identifier.apacitationBaghdan, D., Dugas, L. R., Choo-Kang, C., Plange-Rhule, J., Bovet, P., Viswanathan, B., ... Luke, A. (2021). The associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition. <i>BMC Public Health</i>, 21(1), 2210. http://hdl.handle.net/11427/35425en_ZA
dc.identifier.chicagocitationBaghdan, Danny, Lara R Dugas, Candice Choo-Kang, Jacob Plange-Rhule, Pascal Bovet, Bharathi Viswanathan, Terrence Forrester, et al "The associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition." <i>BMC Public Health</i> 21, 1. (2021): 2210. http://hdl.handle.net/11427/35425en_ZA
dc.identifier.citationBaghdan, D., Dugas, L.R., Choo-Kang, C., Plange-Rhule, J., Bovet, P., Viswanathan, B., Forrester, T. & Lambert, E.V. et al. 2021. The associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition. <i>BMC Public Health.</i> 21(1):2210. http://hdl.handle.net/11427/35425en_ZA
dc.identifier.ris TY - Journal Article AU - Baghdan, Danny AU - Dugas, Lara R AU - Choo-Kang, Candice AU - Plange-Rhule, Jacob AU - Bovet, Pascal AU - Viswanathan, Bharathi AU - Forrester, Terrence AU - Lambert, Estelle V AU - Riesen, Walter AU - Korte, Wolfgang AU - Choudhry, Mashkoor A AU - Luke, Amy AB - Background Cardiometabolic (CM) risk affects approximately 25% of adults globally, and is diagnosed by meeting 3 out of 5 of the following CM risk factors: elevated blood pressure, high triglycerides, elevated blood sugar, low high-density lipoprotein (HDL) level, and abdominal obesity. Adults with CM risk are approximately 22% more likely to have higher mortality rates, and alcohol consumption may be associated with higher CM risk. While previous studies have investigated this potential connection, the majority of them did not include African-origin adults. Therefore, the study aimed to explore the association between alcohol intake and CM risk in 5 African-origin cohorts, spanning the epidemiologic transition in Ghana, South Africa, Jamaica, Seychelles and the United States of America. Methods Measurements included clinical measures for CM risk and self-reported alcohol consumption. Each participant was categorized into one of three drinking categories: non-drinker, light drinker (1–3 drinks daily for men and 1–2 drinks daily for women) and heavy drinker (4 or more drinks every day for men and 3 or more drinks per day for women). Using non-drinker status as the reference, the association between alcohol consumption status and prevalence of each of the five CM risk factors and overall elevated CM risk (having 3 out of 5 risk factors) was explored, adjusting for site, age and sex. Associations were explored using logistic regression and significance was determined using odds ratios (OR) and 95% confidence intervals. Results Neither light nor heavy drinking was associated with increased odds for having higher CM risk compared to nondrinkers (OR = 1.05, p = 0.792 and OR = 1.11, p = 0.489, respectively). However, light drinking was associated with lower odds for having low high density lipoproteins (HDL) cholesterol (OR = 0.69, p = 0.002) and increased risk for high triglycerides (OR = 1.48, p = 0.030). Heavy drinking was associated with elevated blood pressure (OR = 1.59, p = 0.002), high triglycerides (OR = 1.73, p = 0.006) and decreased risk of low HDL-cholesterol (OR = 0.621, p < 0.0005). Finally, country-specific analyses indicated that the relationship between heavy drinking and elevated CM risk varied widely across sites. Conclusion While several CM risk factors were associated with alcohol consumption, the associations were inconsistent and varied widely across five international cohorts of African-origin. Future studies should focus on understanding the individual site-related effects. DA - 2021-12-04 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - BMC Public Health KW - African-origin populations KW - Cardiometabolic risk KW - Alcohol consumption KW - Epidemiologic transition LK - https://open.uct.ac.za PY - 2021 T1 - The associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition TI - The associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition UR - http://hdl.handle.net/11427/35425 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s12889-021-12128-2
dc.identifier.urihttp://hdl.handle.net/11427/35425
dc.identifier.vancouvercitationBaghdan D, Dugas LR, Choo-Kang C, Plange-Rhule J, Bovet P, Viswanathan B, et al. The associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition. BMC Public Health. 2021;21(1):2210. http://hdl.handle.net/11427/35425.en_ZA
dc.language.isoenen_US
dc.language.rfc3066en
dc.publisher.departmentDepartment of Medicineen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceBMC Public Healthen_US
dc.source.journalissue1en_US
dc.source.journalvolume21en_US
dc.source.pagination2210en_US
dc.source.urihttps://bmcpublichealth.biomedcentral.com/
dc.subjectAfrican-origin populationsen_US
dc.subjectCardiometabolic risken_US
dc.subjectAlcohol consumptionen_US
dc.subjectEpidemiologic transitionen_US
dc.titleThe associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transitionen_US
dc.typeJournal Articleen_US
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