MPhil in pulmonary haemorrhage in children in Cape Town

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dc.contributor.advisorVanker, Aneesa
dc.contributor.advisorGray, Diane
dc.contributor.authorMasu, Adelaide Ngina
dc.date.accessioned2025-10-30T12:22:13Z
dc.date.available2025-10-30T12:22:13Z
dc.date.issued2025
dc.date.updated2025-10-30T12:17:54Z
dc.description.abstractIntroduction: Diffuse alveolar haemorrhage (DAH) is a rare condition in childhood which carries high morbidity and mortality. Outcomes are improved by initiating appropriate investigations to ensure early diagnosis and institute correct and timely management. Objectives: To understand the clinicopathological features of DAH and its management on the outcomes of children with this diagnosis. Methods: A descriptive study was conducted on children attending a tertiary centre pulmonology clinic from the period 2000-2022. A review of the clinical data, investigations and lung biopsy results was done and outcomes were reported. Results: Sixteen children were included in the study. The median age at presentation was 1.79 years (IQR 0.48-3.15). At presentation, the median haemoglobulin (Hb)was 5.4 (IQR 3.6-85). Five out of16(31%) had haemoptysis. Seven children showed a pulmonary IgA vasculitis on biopsy. Of the most recent spirometry 5/14 (38.46) had a restrictive pattern. At diagnosis 6/16 (37%) received intravenous methyl-prednisone and 10/16(63%) received oral prednisone as treatment. The children who received more than one immunosuppressant agent as management were 14/16 (87%). Ten out of 16 children are in remission. Conclusion: Early diagnosis of DAH and multidrug management seems to improve outcomes. The finding of isolated IgA vasculitis on lung biopsy associated with DAH has not been well described.
dc.identifier.apacitationMasu, A. N. (2025). <i>MPhil in pulmonary haemorrhage in children in Cape Town</i>. (). University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. Retrieved from http://hdl.handle.net/11427/42065en_ZA
dc.identifier.chicagocitationMasu, Adelaide Ngina. <i>"MPhil in pulmonary haemorrhage in children in Cape Town."</i> ., University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2025. http://hdl.handle.net/11427/42065en_ZA
dc.identifier.citationMasu, A.N. 2025. MPhil in pulmonary haemorrhage in children in Cape Town. . University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. http://hdl.handle.net/11427/42065en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Masu, Adelaide Ngina AB - Introduction: Diffuse alveolar haemorrhage (DAH) is a rare condition in childhood which carries high morbidity and mortality. Outcomes are improved by initiating appropriate investigations to ensure early diagnosis and institute correct and timely management. Objectives: To understand the clinicopathological features of DAH and its management on the outcomes of children with this diagnosis. Methods: A descriptive study was conducted on children attending a tertiary centre pulmonology clinic from the period 2000-2022. A review of the clinical data, investigations and lung biopsy results was done and outcomes were reported. Results: Sixteen children were included in the study. The median age at presentation was 1.79 years (IQR 0.48-3.15). At presentation, the median haemoglobulin (Hb)was 5.4 (IQR 3.6-85). Five out of16(31%) had haemoptysis. Seven children showed a pulmonary IgA vasculitis on biopsy. Of the most recent spirometry 5/14 (38.46) had a restrictive pattern. At diagnosis 6/16 (37%) received intravenous methyl-prednisone and 10/16(63%) received oral prednisone as treatment. The children who received more than one immunosuppressant agent as management were 14/16 (87%). Ten out of 16 children are in remission. Conclusion: Early diagnosis of DAH and multidrug management seems to improve outcomes. The finding of isolated IgA vasculitis on lung biopsy associated with DAH has not been well described. DA - 2025 DB - OpenUCT DP - University of Cape Town KW - Diffuse alveolar haemorrhage KW - Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2025 T1 - MPhil in pulmonary haemorrhage in children in Cape Town TI - MPhil in pulmonary haemorrhage in children in Cape Town UR - http://hdl.handle.net/11427/42065 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/42065
dc.identifier.vancouvercitationMasu AN. MPhil in pulmonary haemorrhage in children in Cape Town. []. University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2025 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/42065en_ZA
dc.language.isoen
dc.language.rfc3066eng
dc.publisher.departmentDepartment of Paediatrics and Child Health
dc.publisher.facultyFaculty of Health Sciences
dc.publisher.institutionUniversity of Cape Town
dc.subjectDiffuse alveolar haemorrhage
dc.subjectCape Town
dc.titleMPhil in pulmonary haemorrhage in children in Cape Town
dc.typeThesis / Dissertation
dc.type.qualificationlevelMasters
dc.type.qualificationlevelMasters
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