HHV-8 seroprevalence: a global view

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dc.contributor.authorRohner, Elianeen_ZA
dc.contributor.authorWyss, Nataschaen_ZA
dc.contributor.authorTrelle, Svenen_ZA
dc.contributor.authorMbulaiteye, Samen_ZA
dc.contributor.authorEgger, Matthiasen_ZA
dc.contributor.authorNovak, Urbanen_ZA
dc.contributor.authorZwahlen, Marcelen_ZA
dc.contributor.authorBohlius, Juliaen_ZA
dc.date.accessioned2015-11-27T09:30:17Z
dc.date.available2015-11-27T09:30:17Z
dc.date.issued2014en_ZA
dc.description.abstractBACKGROUND: Human herpes virus 8 (HHV-8) is the underlying infectious cause of Kaposi sarcoma (KS) and other proliferative diseases; that is, primary effusion lymphoma and multicentric Castleman disease. In regions with high HHV-8 seroprevalence in the general population, KS accounts for a major burden of disease. Outside these endemic regions, HHV-8 prevalence is high in men who have sex with men (MSM) and in migrants from endemic regions. We aim to conduct a systematic literature review and meta-analysis in order 1) to define the global distribution of HHV-8 seroprevalence (primary objective) and 2) to identify risk factors for HHV-8 infection, with a focus on HIV status (secondary objective).METHODS/DESIGN:We will include observational studies reporting data on seroprevalence of HHV-8 in children and/or adults from any region in the world. Case reports and case series as well as any studies with fewer than 50 participants will be excluded. We will search MEDLINE, EMBASE, and relevant conference proceedings without language restriction. Two reviewers will independently screen the identified studies and extract data on study characteristics and quality, study population, risk factors, and reported outcomes, using a standardized form. For the primary objective we will pool the data using a fully bayesian approach for meta-analysis, with random effects at the study level. For the secondary objective (association of HIV and HHV-8) we aim to pool odds ratios for the association of HIV and HHV-8 using a fully bayesian approach for meta-analysis, with random effects at the study level. Sub-group analyses and meta-regression analyses will be used to explore sources of heterogeneity, including factors such as geographical region, calendar years of recruitment, age, gender, ethnicity, socioeconomic status, different risk groups for sexually and parenterally transmitted infections (MSM, sex workers, hemophiliacs, intravenous drug users), comorbidities such as organ transplantation and malaria, test(s) used to measure HHV-8 infection, study design, and study quality.DISCUSSION:Using the proposed systematic review and meta-analysis, we aim to better define the global seroprevalence of HHV-8 and its associated risk factors. This will improve the current understanding of HHV-8 epidemiology, and could suggest measures to prevent HHV-8 infection and to reduce its associated cancer burden.en_ZA
dc.identifier.apacitationRohner, E., Wyss, N., Trelle, S., Mbulaiteye, S., Egger, M., Novak, U., ... Bohlius, J. (2014). HHV-8 seroprevalence: a global view. <i>Systematic Reviews</i>, http://hdl.handle.net/11427/15381en_ZA
dc.identifier.chicagocitationRohner, Eliane, Natascha Wyss, Sven Trelle, Sam Mbulaiteye, Matthias Egger, Urban Novak, Marcel Zwahlen, and Julia Bohlius "HHV-8 seroprevalence: a global view." <i>Systematic Reviews</i> (2014) http://hdl.handle.net/11427/15381en_ZA
dc.identifier.citationRohner, E., Wyss, N., Trelle, S., Mbulaiteye, S. M., Egger, M., Novak, U., ... & Bohlius, J. (2014). HHV-8 seroprevalence: a global view. Systematic Reviews, 3(1), 11.en_ZA
dc.identifier.ris TY - Journal Article AU - Rohner, Eliane AU - Wyss, Natascha AU - Trelle, Sven AU - Mbulaiteye, Sam AU - Egger, Matthias AU - Novak, Urban AU - Zwahlen, Marcel AU - Bohlius, Julia AB - BACKGROUND: Human herpes virus 8 (HHV-8) is the underlying infectious cause of Kaposi sarcoma (KS) and other proliferative diseases; that is, primary effusion lymphoma and multicentric Castleman disease. In regions with high HHV-8 seroprevalence in the general population, KS accounts for a major burden of disease. Outside these endemic regions, HHV-8 prevalence is high in men who have sex with men (MSM) and in migrants from endemic regions. We aim to conduct a systematic literature review and meta-analysis in order 1) to define the global distribution of HHV-8 seroprevalence (primary objective) and 2) to identify risk factors for HHV-8 infection, with a focus on HIV status (secondary objective).METHODS/DESIGN:We will include observational studies reporting data on seroprevalence of HHV-8 in children and/or adults from any region in the world. Case reports and case series as well as any studies with fewer than 50 participants will be excluded. We will search MEDLINE, EMBASE, and relevant conference proceedings without language restriction. Two reviewers will independently screen the identified studies and extract data on study characteristics and quality, study population, risk factors, and reported outcomes, using a standardized form. For the primary objective we will pool the data using a fully bayesian approach for meta-analysis, with random effects at the study level. For the secondary objective (association of HIV and HHV-8) we aim to pool odds ratios for the association of HIV and HHV-8 using a fully bayesian approach for meta-analysis, with random effects at the study level. Sub-group analyses and meta-regression analyses will be used to explore sources of heterogeneity, including factors such as geographical region, calendar years of recruitment, age, gender, ethnicity, socioeconomic status, different risk groups for sexually and parenterally transmitted infections (MSM, sex workers, hemophiliacs, intravenous drug users), comorbidities such as organ transplantation and malaria, test(s) used to measure HHV-8 infection, study design, and study quality.DISCUSSION:Using the proposed systematic review and meta-analysis, we aim to better define the global seroprevalence of HHV-8 and its associated risk factors. This will improve the current understanding of HHV-8 epidemiology, and could suggest measures to prevent HHV-8 infection and to reduce its associated cancer burden. DA - 2014 DB - OpenUCT DO - 10.1186/2046-4053-3-11 DP - University of Cape Town J1 - Systematic Reviews LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - HHV-8 seroprevalence: a global view TI - HHV-8 seroprevalence: a global view UR - http://hdl.handle.net/11427/15381 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15381
dc.identifier.urihttp://dx.doi.org/10.1186/2046-4053-3-11
dc.identifier.vancouvercitationRohner E, Wyss N, Trelle S, Mbulaiteye S, Egger M, Novak U, et al. HHV-8 seroprevalence: a global view. Systematic Reviews. 2014; http://hdl.handle.net/11427/15381.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2014 Rohner et al.; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceSystematic Reviewsen_ZA
dc.source.urihttp://www.systematicreviewsjournal.com/en_ZA
dc.subject.otherHHV-8en_ZA
dc.subject.otherKaposi sarcomaen_ZA
dc.subject.otherHIVen_ZA
dc.subject.otherSeroprevalenceen_ZA
dc.subject.otherMeta-analysisen_ZA
dc.titleHHV-8 seroprevalence: a global viewen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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