The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease

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dc.contributor.advisorRussell, Vivienne Aen_ZA
dc.contributor.authorWarton, Fleur Len_ZA
dc.date.accessioned2015-01-03T05:23:55Z
dc.date.available2015-01-03T05:23:55Z
dc.date.issued2010en_ZA
dc.descriptionIncludes bibliographical references (p. 224-253).en_ZA
dc.description.abstractEarly developmental stress has been shown to produce numerous deleterious effects, e.g. the later development of affective disorders, and this has been related to chronic enhanced hypothalamic-pituitary-adrenal axis activity. Animal studies have shown that maternally separated rats exhibit increased anxiety- and depression-like behaviour in adulthood, although other evidence shows hyperactivity and impulsivity in such cases. Given that stress has these behavioural effects, it is of interest to determine whether early developmental stress might enhance the toxicity of a later unrelated neural insult. The 6-hydroxydopamine (6-OHDA) model of Parkinson's disease involves the selective unilateral lesion of nigrostriatal dopamine neurons. In this group of studies it was hypothesized that maternal separation might enhance the toxic effects of 6-OHDA.en_ZA
dc.identifier.apacitationWarton, F. L. (2010). <i>The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Neurosurgery. Retrieved from http://hdl.handle.net/11427/11069en_ZA
dc.identifier.chicagocitationWarton, Fleur L. <i>"The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Neurosurgery, 2010. http://hdl.handle.net/11427/11069en_ZA
dc.identifier.citationWarton, F. 2010. The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Warton, Fleur L AB - Early developmental stress has been shown to produce numerous deleterious effects, e.g. the later development of affective disorders, and this has been related to chronic enhanced hypothalamic-pituitary-adrenal axis activity. Animal studies have shown that maternally separated rats exhibit increased anxiety- and depression-like behaviour in adulthood, although other evidence shows hyperactivity and impulsivity in such cases. Given that stress has these behavioural effects, it is of interest to determine whether early developmental stress might enhance the toxicity of a later unrelated neural insult. The 6-hydroxydopamine (6-OHDA) model of Parkinson's disease involves the selective unilateral lesion of nigrostriatal dopamine neurons. In this group of studies it was hypothesized that maternal separation might enhance the toxic effects of 6-OHDA. DA - 2010 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease TI - The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease UR - http://hdl.handle.net/11427/11069 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11069
dc.identifier.vancouvercitationWarton FL. The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Neurosurgery, 2010 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11069en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Neurosurgeryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.titleThe effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's diseaseen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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