The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?

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dc.contributor.authorLópez-Cervantes, Juan Pablo
dc.contributor.authorLønnebotn, Marianne
dc.contributor.authorJogi, Nils Oskar
dc.contributor.authorCalciano, Lucia
dc.contributor.authorKuiper, Ingrid Nordeide
dc.contributor.authorDarby, Matthew G
dc.contributor.authorDharmage, Shyamali C
dc.contributor.authorGómez-Real, Francisco
dc.contributor.authorHammer, Barbara
dc.contributor.authorBertelsen, Randi Jacobsen
dc.contributor.authorJohannessen, Ane
dc.contributor.authorWürtz, Anne Mette Lund
dc.contributor.authorMørkve Knudsen, Toril
dc.contributor.authorKoplin, Jennifer
dc.contributor.authorPape, Kathrine
dc.contributor.authorSkulstad, Svein Magne
dc.contributor.authorTimm, Signe
dc.contributor.authorTjalvin, Gro
dc.contributor.authorKrauss-Etschmann, Susanne
dc.contributor.authorAccordini, Simone
dc.contributor.authorSchlünssen, Vivi
dc.contributor.authorKirkeleit, Jorunn
dc.contributor.authorSvanes, Cecilie
dc.date.accessioned2021-12-10T12:50:20Z
dc.date.available2021-12-10T12:50:20Z
dc.date.issued2021-12-01
dc.date.updated2021-12-09T14:31:58Z
dc.description.abstractEmerging research suggests environmental exposures before conception may adversely affect allergies and lung diseases in future generations. Most studies are limited as they have focused on single exposures, not considering that these diseases have a multifactorial origin in which environmental and lifestyle factors are likely to interact. Traditional exposure assessment methods fail to capture the interactions among environmental exposures and their impact on fundamental biological processes, as well as individual and temporal factors. A valid estimation of exposure preconception is difficult since the human reproductive cycle spans decades and the access to germ cells is limited. The exposome is defined as the cumulative measure of external exposures on an organism (external exposome), and the associated biological responses (endogenous exposome) throughout the lifespan, from conception and onwards. An exposome approach implies a targeted or agnostic analysis of the concurrent and temporal multiple exposures, and may, together with recent technological advances, improve the assessment of the environmental contributors to health and disease. This review describes the current knowledge on preconception environmental exposures as related to respiratory health outcomes in offspring. We discuss the usefulness and feasibility of using an exposome approach in this research, advocating for the preconception exposure window to become included in the exposome concept.en_US
dc.identifierdoi: 10.3390/ijerph182312684
dc.identifier.apacitationLópez-Cervantes, J. P., Lønnebotn, M., Jogi, N. O., Calciano, L., Kuiper, I. N., Darby, Matthew G., ... Svanes, C. (2021). The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?. <i>International Journal of Environmental Research and Public Health</i>, 18(23), 12684. http://hdl.handle.net/11427/35453en_ZA
dc.identifier.chicagocitationLópez-Cervantes, Juan Pablo, Marianne Lønnebotn, Nils Oskar Jogi, Lucia Calciano, Ingrid Nordeide Kuiper, Matthew G. Darby, Shyamali C. Dharmage, et al "The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?." <i>International Journal of Environmental Research and Public Health</i> 18, 23. (2021): 12684. http://hdl.handle.net/11427/35453en_ZA
dc.identifier.citationLópez-Cervantes, J.P., Lønnebotn, M., Jogi, N.O., Calciano, L., Kuiper, I.N., Darby, Matthew G., Dharmage, Shyamali C. & Gómez-Real, F. et al. 2021. The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?. <i>International Journal of Environmental Research and Public Health.</i> 18(23):12684. http://hdl.handle.net/11427/35453en_ZA
dc.identifier.risTY - Journal Article AU - López-Cervantes, Juan Pablo AU - Lønnebotn, Marianne AU - Jogi, Nils Oskar AU - Calciano, Lucia AU - Kuiper, Ingrid Nordeide AU - Darby, Matthew G. AU - Dharmage, Shyamali C. AU - Gómez-Real, Francisco AU - Hammer, Barbara AU - Bertelsen, Randi Jacobsen AU - Johannessen, Ane AU - Würtz, Anne Mette Lund AU - Mørkve Knudsen, Toril AU - Koplin, Jennifer AU - Pape, Kathrine AU - Skulstad, Svein Magne AU - Timm, Signe AU - Tjalvin, Gro AU - Krauss-Etschmann, Susanne AU - Accordini, Simone AU - Schlünssen, Vivi AU - Kirkeleit, Jorunn AU - Svanes, Cecilie AB - Emerging research suggests environmental exposures before conception may adversely affect allergies and lung diseases in future generations. Most studies are limited as they have focused on single exposures, not considering that these diseases have a multifactorial origin in which environmental and lifestyle factors are likely to interact. Traditional exposure assessment methods fail to capture the interactions among environmental exposures and their impact on fundamental biological processes, as well as individual and temporal factors. A valid estimation of exposure preconception is difficult since the human reproductive cycle spans decades and the access to germ cells is limited. The exposome is defined as the cumulative measure of external exposures on an organism (external exposome), and the associated biological responses (endogenous exposome) throughout the lifespan, from conception and onwards. An exposome approach implies a targeted or agnostic analysis of the concurrent and temporal multiple exposures, and may, together with recent technological advances, improve the assessment of the environmental contributors to health and disease. This review describes the current knowledge on preconception environmental exposures as related to respiratory health outcomes in offspring. We discuss the usefulness and feasibility of using an exposome approach in this research, advocating for the preconception exposure window to become included in the exposome concept. DA - 2021-12-01 DB - OpenUCT DP - University of Cape Town IS - 23 J1 - International Journal of Environmental Research and Public Health LK - https://open.uct.ac.za PY - 2021 T1 - The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome? TI - The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome? UR - http://hdl.handle.net/11427/35453 ER -en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/35453
dc.identifier.vancouvercitationLópez-Cervantes JP, Lønnebotn M, Jogi NO, Calciano L, Kuiper IN, Darby Matthew G, et al. The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?. International Journal of Environmental Research and Public Health. 2021;18(23):12684. http://hdl.handle.net/11427/35453.en_ZA
dc.language.isoenen_US
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceInternational Journal of Environmental Research and Public Healthen_US
dc.source.journalissue23en_US
dc.source.journalvolume18en_US
dc.source.pagination12684en_US
dc.source.urihttps://www.mdpi.com/journal/ijerph
dc.titleThe Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?en_US
dc.typeJournal Articleen_US
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