Prevalence, predictors, and association of probable non-specific psychological distress and depression with HIV viral load among postpartum women in Cape Town, South Africa

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dc.contributor.advisorMyer, Landon
dc.contributor.advisorOdayar, Jasantha
dc.contributor.authorArendse, Gwendoline
dc.date.accessioned2023-02-23T10:19:40Z
dc.date.available2023-02-23T10:19:40Z
dc.date.issued2022
dc.date.updated2023-02-20T12:12:50Z
dc.description.abstractBackground: Psychological distress and depressive symptoms are prevalent among postpartum women living with HIV and may affect engagement in HIV care. We examined the prevalence and predictors of probable non-specific psychological distress and depressive symptoms and their association with elevated viral load (VL) in Cape Town, South Africa. Methods: This was a secondary analysis of data from the Postpartum Adherence Clubs for Antiretroviral Therapy trial which enrolled women who were initiated on antiretroviral therapy during the index pregnancy, had a VL 1000 copies/mL) through 24 months postpartum. Results: Among 401 women, 8% and 5% had elevated levels of psychological distress and depression, respectively. After adjusting for socio-demographic, obstetric, maternal, and HIV-related covariates, completion of some high school (adjusted odds ratio [aOR] 0.06; 95% confidence interval [CI] 0.01–0.55) and multiple infant delivery (aOR 12.82; 95% CI 1.25–127.11) were associated with elevated levels of psychological distress. Depressive symptoms were not associated with any of the covariates in an adjusted model. Neither psychological distress nor depressive symptoms were independently associated with viraemia at 24 months postpartum in a multivariable model. There were no significant differences between women with and without mental health-related outcomes in the time to elevated VL through 24 months postpartum. Conclusion: Non-specific psychological distress and depression remain prevalent among postpartum women living with HIV. Further research should explore the longitudinal effect of mental health-related outcomes and VL and interventions should be implemented to improve mental health-related problems in this population.
dc.identifier.apacitationArendse, G. (2022). <i>Prevalence, predictors, and association of probable non-specific psychological distress and depression with HIV viral load among postpartum women in Cape Town, South Africa</i>. (). ,Faculty of Health Sciences ,Department of Public Health and Family Medicine. Retrieved from http://hdl.handle.net/11427/37018en_ZA
dc.identifier.chicagocitationArendse, Gwendoline. <i>"Prevalence, predictors, and association of probable non-specific psychological distress and depression with HIV viral load among postpartum women in Cape Town, South Africa."</i> ., ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2022. http://hdl.handle.net/11427/37018en_ZA
dc.identifier.citationArendse, G. 2022. Prevalence, predictors, and association of probable non-specific psychological distress and depression with HIV viral load among postpartum women in Cape Town, South Africa. . ,Faculty of Health Sciences ,Department of Public Health and Family Medicine. http://hdl.handle.net/11427/37018en_ZA
dc.identifier.ris TY - Master Thesis AU - Arendse, Gwendoline AB - Background: Psychological distress and depressive symptoms are prevalent among postpartum women living with HIV and may affect engagement in HIV care. We examined the prevalence and predictors of probable non-specific psychological distress and depressive symptoms and their association with elevated viral load (VL) in Cape Town, South Africa. Methods: This was a secondary analysis of data from the Postpartum Adherence Clubs for Antiretroviral Therapy trial which enrolled women who were initiated on antiretroviral therapy during the index pregnancy, had a VL 1000 copies/mL) through 24 months postpartum. Results: Among 401 women, 8% and 5% had elevated levels of psychological distress and depression, respectively. After adjusting for socio-demographic, obstetric, maternal, and HIV-related covariates, completion of some high school (adjusted odds ratio [aOR] 0.06; 95% confidence interval [CI] 0.01–0.55) and multiple infant delivery (aOR 12.82; 95% CI 1.25–127.11) were associated with elevated levels of psychological distress. Depressive symptoms were not associated with any of the covariates in an adjusted model. Neither psychological distress nor depressive symptoms were independently associated with viraemia at 24 months postpartum in a multivariable model. There were no significant differences between women with and without mental health-related outcomes in the time to elevated VL through 24 months postpartum. Conclusion: Non-specific psychological distress and depression remain prevalent among postpartum women living with HIV. Further research should explore the longitudinal effect of mental health-related outcomes and VL and interventions should be implemented to improve mental health-related problems in this population. DA - 2022_ DB - OpenUCT DP - University of Cape Town KW - Epidemiology and Biostatistics LK - https://open.uct.ac.za PY - 2022 T1 - Prevalence, predictors, and association of probable non-specific psychological distress and depression with HIV viral load among postpartum women in Cape Town, South Africa TI - Prevalence, predictors, and association of probable non-specific psychological distress and depression with HIV viral load among postpartum women in Cape Town, South Africa UR - http://hdl.handle.net/11427/37018 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/37018
dc.identifier.vancouvercitationArendse G. Prevalence, predictors, and association of probable non-specific psychological distress and depression with HIV viral load among postpartum women in Cape Town, South Africa. []. ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2022 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/37018en_ZA
dc.language.rfc3066eng
dc.publisher.departmentDepartment of Public Health and Family Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.subjectEpidemiology and Biostatistics
dc.titlePrevalence, predictors, and association of probable non-specific psychological distress and depression with HIV viral load among postpartum women in Cape Town, South Africa
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationlevelMPH
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