Effect of oral fructose on ethanol elimination from the bloodstream

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dc.contributor.authorBerman, P.
dc.contributor.authorBaumgarten, I.
dc.contributor.authorViljoen, D.L.
dc.date.accessioned2015-12-23T11:33:46Z
dc.date.available2015-12-23T11:33:46Z
dc.date.issued2003
dc.date.updated2015-12-23T11:04:55Z
dc.description.abstractAlcohol has been identified as a major factor contributing to traffic accidents in South Africa, affecting both drivers and pedestrians alike. An agent capable of facilitating ethanol metabolism safely and effectively is of potential value in reducing the frequency of such incidents, and for individuals wishing to reduce their blood alcohol to levels below the legal limit before taking control of a vehicle. Here we show that fructose, at a dose of 1 g/kg, fulfils the criteria for such an agent. When ingested by healthy volunteers who had imbibed ethanol equivalent to 8 standard tots, it reduced the time required to attain a legal blood alcohol level (50 mg%) by approximately 70 min (n = 9). When ingested before a dose of alcohol equivalent to a double tot, fructose reduced both the magnitude and duration of the subsequent increase in blood alcohol; mean peak height, area under the curve, and time taken to reach zero were 39%, 32% and 51%, respectively, of that observed in the absence of fructose (n = 12). We conclude that, whether taken after imbibing alcoholic beverages or prophylactically before commencing drinking, oral fructose significantly lowers blood alcohol levels and reduces the time required for alcohol to disappear from the bloodstream.en_ZA
dc.identifier.apacitationBerman, P., Baumgarten, I., & Viljoen, D. L. (2003). Effect of oral fructose on ethanol elimination from the bloodstream. <i>South African Journal of Science</i>, http://hdl.handle.net/11427/15935en_ZA
dc.identifier.chicagocitationBerman, P., I. Baumgarten, and D.L. Viljoen "Effect of oral fructose on ethanol elimination from the bloodstream." <i>South African Journal of Science</i> (2003) http://hdl.handle.net/11427/15935en_ZA
dc.identifier.citationBerman, P., Baumgarten, I., & Viljoen, D. (2003). Effect of oral fructose on ethanol elimination from the bloodstream: Research in action. South African Journal of Science, 99(1 & 2), p. 47-50.en_ZA
dc.identifier.issn0038-2353en_ZA
dc.identifier.ris TY - Journal Article AU - Berman, P. AU - Baumgarten, I. AU - Viljoen, D.L. AB - Alcohol has been identified as a major factor contributing to traffic accidents in South Africa, affecting both drivers and pedestrians alike. An agent capable of facilitating ethanol metabolism safely and effectively is of potential value in reducing the frequency of such incidents, and for individuals wishing to reduce their blood alcohol to levels below the legal limit before taking control of a vehicle. Here we show that fructose, at a dose of 1 g/kg, fulfils the criteria for such an agent. When ingested by healthy volunteers who had imbibed ethanol equivalent to 8 standard tots, it reduced the time required to attain a legal blood alcohol level (50 mg%) by approximately 70 min (n = 9). When ingested before a dose of alcohol equivalent to a double tot, fructose reduced both the magnitude and duration of the subsequent increase in blood alcohol; mean peak height, area under the curve, and time taken to reach zero were 39%, 32% and 51%, respectively, of that observed in the absence of fructose (n = 12). We conclude that, whether taken after imbibing alcoholic beverages or prophylactically before commencing drinking, oral fructose significantly lowers blood alcohol levels and reduces the time required for alcohol to disappear from the bloodstream. DA - 2003 DB - OpenUCT DP - University of Cape Town J1 - South African Journal of Science LK - https://open.uct.ac.za PB - University of Cape Town PY - 2003 SM - 0038-2353 T1 - Effect of oral fructose on ethanol elimination from the bloodstream TI - Effect of oral fructose on ethanol elimination from the bloodstream UR - http://hdl.handle.net/11427/15935 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15935
dc.identifier.vancouvercitationBerman P, Baumgarten I, Viljoen DL. Effect of oral fructose on ethanol elimination from the bloodstream. South African Journal of Science. 2003; http://hdl.handle.net/11427/15935.en_ZA
dc.languageengen_ZA
dc.publisherAcademy of Science of South Africa (ASSAf)en_ZA
dc.publisher.departmentDepartment of Clinical Laboratory Sciencesen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_ZA
dc.sourceSouth African Journal of Scienceen_ZA
dc.source.urihttp://www.sajs.co.za/
dc.titleEffect of oral fructose on ethanol elimination from the bloodstreamen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetype
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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