Accuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients

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dc.contributor.advisorChetty, Dharshnee Rama
dc.contributor.advisorMalherbe Francois
dc.contributor.authorFakier, Ghaalied
dc.date.accessioned2026-06-22T12:22:11Z
dc.date.available2026-06-22T12:22:11Z
dc.date.issued2026
dc.date.updated2026-06-22T11:26:57Z
dc.description.abstractBreast cancer remains a leading cause of cancer-related morbidity and mortality globally. Accurate staging is essential for appropriate management, yet breast cancer staging practices vary and are not universally standardized. Intraoperative sentinel lymph node biopsy (SLNB) with frozen section (FS) analysis is commonly employed to detect axillary lymph node metastases. When nodal metastases are identified, axillary lymph node dissection (ALND) is often performed. However, ALND is associated with significant morbidity and can negatively impact quality of life. The increasing use of neoadjuvant chemotherapy (NAC) and radiotherapy has the potential to downstage disease, but intraoperative FS analysis remains relevant, identifying individuals needing ALND. While international data supports this trend, variability in healthcare systems and patient populations limits the generalizability of these findings to the South African context.
dc.identifier.apacitationFakier, G. (2026). <i>Accuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients</i>. (). University of Cape Town ,Faculty of Health Sciences ,Department of Pathology. Retrieved from http://hdl.handle.net/11427/43347en_ZA
dc.identifier.chicagocitationFakier, Ghaalied. <i>"Accuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients."</i> ., University of Cape Town ,Faculty of Health Sciences ,Department of Pathology, 2026. http://hdl.handle.net/11427/43347en_ZA
dc.identifier.citationFakier, G. 2026. Accuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients. . University of Cape Town ,Faculty of Health Sciences ,Department of Pathology. http://hdl.handle.net/11427/43347en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Fakier, Ghaalied AB - Breast cancer remains a leading cause of cancer-related morbidity and mortality globally. Accurate staging is essential for appropriate management, yet breast cancer staging practices vary and are not universally standardized. Intraoperative sentinel lymph node biopsy (SLNB) with frozen section (FS) analysis is commonly employed to detect axillary lymph node metastases. When nodal metastases are identified, axillary lymph node dissection (ALND) is often performed. However, ALND is associated with significant morbidity and can negatively impact quality of life. The increasing use of neoadjuvant chemotherapy (NAC) and radiotherapy has the potential to downstage disease, but intraoperative FS analysis remains relevant, identifying individuals needing ALND. While international data supports this trend, variability in healthcare systems and patient populations limits the generalizability of these findings to the South African context. DA - 2026 DB - OpenUCT DP - University of Cape Town KW - Breast carcinoma, frozen section, sentinel lymph node, ACOSOG Z011, axillary LK - https://open.uct.ac.za PB - University of Cape Town PY - 2026 T1 - Accuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients TI - Accuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients UR - http://hdl.handle.net/11427/43347 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/43347
dc.identifier.vancouvercitationFakier G. Accuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients. []. University of Cape Town ,Faculty of Health Sciences ,Department of Pathology, 2026 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/43347en_ZA
dc.language.isoen
dc.language.rfc3066eng
dc.publisher.departmentDepartment of Pathology
dc.publisher.facultyFaculty of Health Sciences
dc.publisher.institutionUniversity of Cape Town
dc.subjectBreast carcinoma, frozen section, sentinel lymph node, ACOSOG Z011, axillary
dc.titleAccuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients
dc.typeThesis / Dissertation
dc.type.qualificationlevelMasters
dc.type.qualificationlevelMMed
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