Lack of paradoxical bronchoconstriction after administration of tiotropium via Respimat® Soft Mist™ Inhaler in COPD

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dc.contributor.authorHodder, Rick
dc.contributor.authorLee, Angela
dc.contributor.authorBateman, Eric
dc.date.accessioned2021-10-08T07:04:19Z
dc.date.available2021-10-08T07:04:19Z
dc.date.issued2011
dc.description.abstractBronchoconstriction has been reported in asthma and chronic obstructive pulmonary disease (COPD) patients after administration of some aqueous inhalation solutions. We investigated the incidence of this event during long-term clinical trials of tiotropium delivered via Respimat® Soft Mist™ Inhaler (SMI). We retrospectively analyzed pooled data from two identical Phase III clinical trials, in which 1990 patients with COPD received 48 weeks’ treatment with once-daily tiotropium (5 or 10 μg) or placebo inhaled via Respimat® SMI. We recorded the incidence of bronchospasm and of a range of respiratory events that could suggest bronchoconstriction during the first 30 minutes after inhalation of study treatment on each of the eight test days. No patients reported bronchospasm. Six patients (0.3%) reported a combination of at least two events suggestive of bronchoconstriction, and 21 (1.1%) reported either rescue medication use or a respiratory adverse event. Asymptomatic falls in forced expiratory volume in one second (FEV1) of ≥15% were recorded on all test days, with no change in incidence over time, and affected 8.2% of those in the tiotropium groups and 14.5% of those on placebo. In COPD patients receiving long-term treatment with tiotropium 5 or 10 μg via Respimat® SMI, no bronchospasm was recorded, and the number of events possibly indicative of paradoxical bronchoconstriction was very low.
dc.identifier.apacitationHodder, R., Lee, A., & Bateman, E. (2011). Lack of paradoxical bronchoconstriction after administration of tiotropium via Respimat® Soft Mist™ Inhaler in COPD. <i>International Journal of Chronic Obstructive Pulmonary Disease</i>, 49(4), 245 - 177. http://hdl.handle.net/11427/34481en_ZA
dc.identifier.chicagocitationHodder, Rick, Angela Lee, and Eric Bateman "Lack of paradoxical bronchoconstriction after administration of tiotropium via Respimat® Soft Mist™ Inhaler in COPD." <i>International Journal of Chronic Obstructive Pulmonary Disease</i> 49, 4. (2011): 245 - 177. http://hdl.handle.net/11427/34481en_ZA
dc.identifier.citationHodder, R., Lee, A. & Bateman, E. 2011. Lack of paradoxical bronchoconstriction after administration of tiotropium via Respimat® Soft Mist™ Inhaler in COPD. <i>International Journal of Chronic Obstructive Pulmonary Disease.</i> 49(4):245 - 177. http://hdl.handle.net/11427/34481en_ZA
dc.identifier.issn1176-9106
dc.identifier.issn1178-2005
dc.identifier.ris TY - Journal Article AU - Hodder, Rick AU - Lee, Angela AU - Bateman, Eric AB - Bronchoconstriction has been reported in asthma and chronic obstructive pulmonary disease (COPD) patients after administration of some aqueous inhalation solutions. We investigated the incidence of this event during long-term clinical trials of tiotropium delivered via Respimat® Soft Mist™ Inhaler (SMI). We retrospectively analyzed pooled data from two identical Phase III clinical trials, in which 1990 patients with COPD received 48 weeks’ treatment with once-daily tiotropium (5 or 10 μg) or placebo inhaled via Respimat® SMI. We recorded the incidence of bronchospasm and of a range of respiratory events that could suggest bronchoconstriction during the first 30 minutes after inhalation of study treatment on each of the eight test days. No patients reported bronchospasm. Six patients (0.3%) reported a combination of at least two events suggestive of bronchoconstriction, and 21 (1.1%) reported either rescue medication use or a respiratory adverse event. Asymptomatic falls in forced expiratory volume in one second (FEV1) of ≥15% were recorded on all test days, with no change in incidence over time, and affected 8.2% of those in the tiotropium groups and 14.5% of those on placebo. In COPD patients receiving long-term treatment with tiotropium 5 or 10 μg via Respimat® SMI, no bronchospasm was recorded, and the number of events possibly indicative of paradoxical bronchoconstriction was very low. DA - 2011 DB - OpenUCT DP - University of Cape Town IS - 4 J1 - International Journal of Chronic Obstructive Pulmonary Disease LK - https://open.uct.ac.za PY - 2011 SM - 1176-9106 SM - 1178-2005 T1 - Lack of paradoxical bronchoconstriction after administration of tiotropium via Respimat® Soft Mist™ Inhaler in COPD TI - Lack of paradoxical bronchoconstriction after administration of tiotropium via Respimat® Soft Mist™ Inhaler in COPD UR - http://hdl.handle.net/11427/34481 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34481
dc.identifier.vancouvercitationHodder R, Lee A, Bateman E. Lack of paradoxical bronchoconstriction after administration of tiotropium via Respimat® Soft Mist™ Inhaler in COPD. International Journal of Chronic Obstructive Pulmonary Disease. 2011;49(4):245 - 177. http://hdl.handle.net/11427/34481.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Pulmonology
dc.publisher.facultyFaculty of Health Sciences
dc.sourceInternational Journal of Chronic Obstructive Pulmonary Disease
dc.source.journalissue4
dc.source.journalvolume49
dc.source.pagination245 - 177
dc.source.urihttps://dx.doi.org/10.2147/COPD.S16094
dc.subject.otherCOPD
dc.subject.otherbronchoconstriction
dc.subject.otherinhalation device
dc.subject.othertiotropium
dc.subject.otherAdministration, Inhalation
dc.subject.otherAged
dc.subject.otherBronchial Spasm
dc.subject.otherBronchoconstriction
dc.subject.otherBronchodilator Agents
dc.subject.otherCholinergic Antagonists
dc.subject.otherClinical Trials, Phase III as Topic
dc.subject.otherFemale
dc.subject.otherForced Expiratory Volume
dc.subject.otherHumans
dc.subject.otherLogistic Models
dc.subject.otherLung
dc.subject.otherMale
dc.titleLack of paradoxical bronchoconstriction after administration of tiotropium via Respimat® Soft Mist™ Inhaler in COPD
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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