Fasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans: a clamp study in sub-Saharan Africans

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dc.contributor.authorSobngwi, Eugeneen_ZA
dc.contributor.authorKengne, Andre-Pascalen_ZA
dc.contributor.authorEchouffo-Tcheugui, Justinen_ZA
dc.contributor.authorChoukem, Simeonen_ZA
dc.contributor.authorSobngwi-Tambekou, Joelleen_ZA
dc.contributor.authorBalti, Ericen_ZA
dc.contributor.authorPearce, Marken_ZA
dc.contributor.authorSiaha, Valentinen_ZA
dc.contributor.authorMamdjokam, Aissaen_ZA
dc.contributor.authorEffoe, Valeryen_ZA
dc.contributor.authorLontchi-Yimagou, Ericen_ZA
dc.contributor.authorDonfack, Oliveren_ZA
dc.contributor.authorAtogho-Tiedeu, Barbaraen_ZA
dc.date.accessioned2015-11-27T09:33:37Z
dc.date.available2015-11-27T09:33:37Z
dc.date.issued2014en_ZA
dc.description.abstractBACKGROUND: We aimed to evaluate the predictive utility of common fasting insulin sensitivity indices, and non-laboratory surrogates [BMI, waist circumference (WC) and waist-to-height ratio (WHtR)] in sub-Saharan Africans without diabetes. METHODS: We measured fasting glucose and insulin, and glucose uptake during 80/mU/m2/min euglycemic clamp in 87 Cameroonians (51 men) aged (SD) 34.6 (11.4) years. We derived insulin sensitivity indices including HOMA-IR, quantitative insulin sensitivity check index (QUICKI), fasting insulin resistance index (FIRI) and glucose-to-insulin ratio (GIR). Indices and clinical predictors were compared to clamp using correlation tests, robust linear regressions and agreement of classification by sex-specific thirds. RESULTS: The mean insulin sensitivity was M =10.5+/-3.2mg/kg/min. Classification across thirds of insulin sensitivity by clamp matched with non-laboratory surrogates in 30-48% of participants, and with fasting indices in 27-51%, with kappa statistics ranging from 0.10 to 0.26. Fasting indices correlated significantly with clamp (/r/=0.23-0.30), with GIR performing less well than fasting insulin and HOMA-IR (both p <0.02). BMI, WC and WHtR were equal or superior to fasting indices (/r/=0.38-0.43). Combinations of fasting indices and clinical predictors explained 25-27% of variation in clamp values. CONCLUSION: Fasting insulin sensitivity indices are modest predictors of insulin sensitivity measured by euglycemic clamp, and do not perform better than clinical surrogates in this population.en_ZA
dc.identifier.apacitationSobngwi, E., Kengne, A., Echouffo-Tcheugui, J., Choukem, S., Sobngwi-Tambekou, J., Balti, E., ... Atogho-Tiedeu, B. (2014). Fasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans: a clamp study in sub-Saharan Africans. <i>BMC Endocrine Disorders</i>, http://hdl.handle.net/11427/15396en_ZA
dc.identifier.chicagocitationSobngwi, Eugene, Andre-Pascal Kengne, Justin Echouffo-Tcheugui, Simeon Choukem, Joelle Sobngwi-Tambekou, Eric Balti, Mark Pearce, et al "Fasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans: a clamp study in sub-Saharan Africans." <i>BMC Endocrine Disorders</i> (2014) http://hdl.handle.net/11427/15396en_ZA
dc.identifier.citationSobngwi, E., Kengne, A. P., Echouffo-Tcheugui, J. B., Choukem, S., Sobngwi-Tambekou, J., Balti, E. V., ... & Mbanya, J. C. (2014). Fasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans: a clamp study in sub-Saharan Africans. BMC endocrine disorders, 14(1), 65.en_ZA
dc.identifier.ris TY - Journal Article AU - Sobngwi, Eugene AU - Kengne, Andre-Pascal AU - Echouffo-Tcheugui, Justin AU - Choukem, Simeon AU - Sobngwi-Tambekou, Joelle AU - Balti, Eric AU - Pearce, Mark AU - Siaha, Valentin AU - Mamdjokam, Aissa AU - Effoe, Valery AU - Lontchi-Yimagou, Eric AU - Donfack, Oliver AU - Atogho-Tiedeu, Barbara AB - BACKGROUND: We aimed to evaluate the predictive utility of common fasting insulin sensitivity indices, and non-laboratory surrogates [BMI, waist circumference (WC) and waist-to-height ratio (WHtR)] in sub-Saharan Africans without diabetes. METHODS: We measured fasting glucose and insulin, and glucose uptake during 80/mU/m2/min euglycemic clamp in 87 Cameroonians (51 men) aged (SD) 34.6 (11.4) years. We derived insulin sensitivity indices including HOMA-IR, quantitative insulin sensitivity check index (QUICKI), fasting insulin resistance index (FIRI) and glucose-to-insulin ratio (GIR). Indices and clinical predictors were compared to clamp using correlation tests, robust linear regressions and agreement of classification by sex-specific thirds. RESULTS: The mean insulin sensitivity was M =10.5+/-3.2mg/kg/min. Classification across thirds of insulin sensitivity by clamp matched with non-laboratory surrogates in 30-48% of participants, and with fasting indices in 27-51%, with kappa statistics ranging from 0.10 to 0.26. Fasting indices correlated significantly with clamp (/r/=0.23-0.30), with GIR performing less well than fasting insulin and HOMA-IR (both p <0.02). BMI, WC and WHtR were equal or superior to fasting indices (/r/=0.38-0.43). Combinations of fasting indices and clinical predictors explained 25-27% of variation in clamp values. CONCLUSION: Fasting insulin sensitivity indices are modest predictors of insulin sensitivity measured by euglycemic clamp, and do not perform better than clinical surrogates in this population. DA - 2014 DB - OpenUCT DO - 10.1186/1472-6823-14-65 DP - University of Cape Town J1 - BMC Endocrine Disorders LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Fasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans: a clamp study in sub-Saharan Africans TI - Fasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans: a clamp study in sub-Saharan Africans UR - http://hdl.handle.net/11427/15396 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15396
dc.identifier.urihttp://dx.doi.org/10.1186/1472-6823-14-65
dc.identifier.vancouvercitationSobngwi E, Kengne A, Echouffo-Tcheugui J, Choukem S, Sobngwi-Tambekou J, Balti E, et al. Fasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans: a clamp study in sub-Saharan Africans. BMC Endocrine Disorders. 2014; http://hdl.handle.net/11427/15396.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2014 Sobngwi et al.; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0.en_ZA
dc.sourceBMC Endocrine Disordersen_ZA
dc.source.urihttp://www.biomedcentral.com/bmcendocrdisord/en_ZA
dc.subject.otherfasting insulin sensitivity indicesen_ZA
dc.subject.othersub-Saharan Africansen_ZA
dc.subject.otherdiabetesen_ZA
dc.titleFasting insulin sensitivity indices are not better than routine clinical variables at predicting insulin sensitivity among Black Africans: a clamp study in sub-Saharan Africansen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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