Phytochemical studies on traditional medicinal plants with antimalarial activities

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dc.contributor.advisorGammon, David Wen_ZA
dc.contributor.advisorCampbell, William Een_ZA
dc.contributor.authorChen, Dianne Tzu-Hsiuen_ZA
dc.date.accessioned2016-09-20T12:35:23Z
dc.date.available2016-09-20T12:35:23Z
dc.date.issued1997en_ZA
dc.description.abstractThe active antimalarial principles of three traditional medicinal plants, Passerina obtusifolia (Thymelaeaceae), Tetradenia riparia (Labiatea) and Xerophyta retinervis (V elloziaceae) were investigated by employing bioassay guided fractionation. Two novel compounds and five known constituents were isolated from the active fractions of these three plants. The types of compounds isolated included: three triterpenoids (20(29)-Lupene-3α,28- diol (30), 20(29)-Lupene-3α, 16β,28-triol (32) and 3β-Hydroxy-20(29)-Lupen-28-oic acid (42)); two diterpenoids (8-Abietene-7 β,13 β -diol (45) and cariocal (51)); one flavonoid ( 5-Hydroxy:.4' ,6, 7-trimethoxyflavone ( 44)) and one flavonolignan ( 11-0- acetyl hydnocarpin (62)). In addition, one analogue of 7α-hydroxyroyleanone (41) (which was previously isolated from T riparia and was found to be the active antimalarial principle of the plant) was prepared.en_ZA
dc.identifier.apacitationChen, D. T. (1997). <i>Phytochemical studies on traditional medicinal plants with antimalarial activities</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/21853en_ZA
dc.identifier.chicagocitationChen, Dianne Tzu-Hsiu. <i>"Phytochemical studies on traditional medicinal plants with antimalarial activities."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1997. http://hdl.handle.net/11427/21853en_ZA
dc.identifier.citationChen, D. 1997. Phytochemical studies on traditional medicinal plants with antimalarial activities. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Chen, Dianne Tzu-Hsiu AB - The active antimalarial principles of three traditional medicinal plants, Passerina obtusifolia (Thymelaeaceae), Tetradenia riparia (Labiatea) and Xerophyta retinervis (V elloziaceae) were investigated by employing bioassay guided fractionation. Two novel compounds and five known constituents were isolated from the active fractions of these three plants. The types of compounds isolated included: three triterpenoids (20(29)-Lupene-3α,28- diol (30), 20(29)-Lupene-3α, 16β,28-triol (32) and 3β-Hydroxy-20(29)-Lupen-28-oic acid (42)); two diterpenoids (8-Abietene-7 β,13 β -diol (45) and cariocal (51)); one flavonoid ( 5-Hydroxy:.4' ,6, 7-trimethoxyflavone ( 44)) and one flavonolignan ( 11-0- acetyl hydnocarpin (62)). In addition, one analogue of 7α-hydroxyroyleanone (41) (which was previously isolated from T riparia and was found to be the active antimalarial principle of the plant) was prepared. DA - 1997 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1997 T1 - Phytochemical studies on traditional medicinal plants with antimalarial activities TI - Phytochemical studies on traditional medicinal plants with antimalarial activities UR - http://hdl.handle.net/11427/21853 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/21853
dc.identifier.vancouvercitationChen DT. Phytochemical studies on traditional medicinal plants with antimalarial activities. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1997 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/21853en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titlePhytochemical studies on traditional medicinal plants with antimalarial activitiesen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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