The burden of imported malaria in Gauteng Province

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dc.contributor.authorWeber, Ingrid B
dc.contributor.authorBaker, Lee
dc.contributor.authorMnyaluza, Joy
dc.contributor.authorMatjila, Maila J
dc.contributor.authorBarnes, Karen
dc.contributor.authorBlumberg, Lucille
dc.date.accessioned2021-10-08T07:17:58Z
dc.date.available2021-10-08T07:17:58Z
dc.date.issued2010
dc.description.abstractOBJECTIVES: To describe the burden of malaria in Gauteng Province, and to identify potential risk factors for severe disease. DESIGN: We conducted a prospective survey of malaria cases diagnosed in hospitals throughout Gauteng from December 2005 to end November 2006. OUTCOME MEASURES: Malaria frequency, severity, and treatment. Results. We identified 1 701 malaria cases; 1 548 (91%) were seen at public sector hospitals and 153 (9%) at private hospitals; 1 149 (68%) patients were male. Median age was 27 years (range 1 month - 89 years). Most (84%) infections were acquired in Mozambique. Disease severity did not differ by age or sex. Patients who were South African-born were more likely to have severe disease (OR=1.43 (1.08 - 1.91)), as were patients who experienced a delay >48 hours between onset of symptoms and diagnosis or treatment (OR=1.98 (1.48 - 2.65)). While most patients appropriately received quinine, only 9% of severe malaria cases received the recommended loading dose. CONCLUSIONS: The incidence of malaria in Gauteng was higher than previously reported, emphasising the need to prevent malaria in travellers by correct use of non-drug measures and, when indicated, malaria chemoprophylaxis. Disease severity was increased by delays between onset and treatment and lack of partial immunity. Providers should consult the latest guidelines for treatment of malaria in South Africa, particularly about treatment of severe malaria. A change in drug policy to artemisinin combination therapy for imported uncomplicated malaria in non-malaria risk provinces should be strongly considered.
dc.identifier.apacitationWeber, I. B., Baker, L., Mnyaluza, J., Matjila, M. J., Barnes, K., & Blumberg, L. (2010). The burden of imported malaria in Gauteng Province. <i>South African Medical Journal</i>, 100(5), 300 - 177. http://hdl.handle.net/11427/34872en_ZA
dc.identifier.chicagocitationWeber, Ingrid B, Lee Baker, Joy Mnyaluza, Maila J Matjila, Karen Barnes, and Lucille Blumberg "The burden of imported malaria in Gauteng Province." <i>South African Medical Journal</i> 100, 5. (2010): 300 - 177. http://hdl.handle.net/11427/34872en_ZA
dc.identifier.citationWeber, I.B., Baker, L., Mnyaluza, J., Matjila, M.J., Barnes, K. & Blumberg, L. 2010. The burden of imported malaria in Gauteng Province. <i>South African Medical Journal.</i> 100(5):300 - 177. http://hdl.handle.net/11427/34872en_ZA
dc.identifier.issn0038-2469
dc.identifier.ris TY - Journal Article AU - Weber, Ingrid B AU - Baker, Lee AU - Mnyaluza, Joy AU - Matjila, Maila J AU - Barnes, Karen AU - Blumberg, Lucille AB - OBJECTIVES: To describe the burden of malaria in Gauteng Province, and to identify potential risk factors for severe disease. DESIGN: We conducted a prospective survey of malaria cases diagnosed in hospitals throughout Gauteng from December 2005 to end November 2006. OUTCOME MEASURES: Malaria frequency, severity, and treatment. Results. We identified 1 701 malaria cases; 1 548 (91%) were seen at public sector hospitals and 153 (9%) at private hospitals; 1 149 (68%) patients were male. Median age was 27 years (range 1 month - 89 years). Most (84%) infections were acquired in Mozambique. Disease severity did not differ by age or sex. Patients who were South African-born were more likely to have severe disease (OR=1.43 (1.08 - 1.91)), as were patients who experienced a delay >48 hours between onset of symptoms and diagnosis or treatment (OR=1.98 (1.48 - 2.65)). While most patients appropriately received quinine, only 9% of severe malaria cases received the recommended loading dose. CONCLUSIONS: The incidence of malaria in Gauteng was higher than previously reported, emphasising the need to prevent malaria in travellers by correct use of non-drug measures and, when indicated, malaria chemoprophylaxis. Disease severity was increased by delays between onset and treatment and lack of partial immunity. Providers should consult the latest guidelines for treatment of malaria in South Africa, particularly about treatment of severe malaria. A change in drug policy to artemisinin combination therapy for imported uncomplicated malaria in non-malaria risk provinces should be strongly considered. DA - 2010 DB - OpenUCT DP - University of Cape Town IS - 5 J1 - South African Medical Journal LK - https://open.uct.ac.za PY - 2010 SM - 0038-2469 T1 - The burden of imported malaria in Gauteng Province TI - The burden of imported malaria in Gauteng Province UR - http://hdl.handle.net/11427/34872 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34872
dc.identifier.vancouvercitationWeber IB, Baker L, Mnyaluza J, Matjila MJ, Barnes K, Blumberg L. The burden of imported malaria in Gauteng Province. South African Medical Journal. 2010;100(5):300 - 177. http://hdl.handle.net/11427/34872.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Clinical Pharmacology
dc.publisher.facultyFaculty of Health Sciences
dc.sourceSouth African Medical Journal
dc.source.journalissue5
dc.source.journalvolume100
dc.source.pagination300 - 177
dc.source.urihttps://dx.doi.org/10.7196/SAMJ.3599
dc.subject.otherTropical medicine
dc.subject.otherTravel medicine
dc.subject.otherMalaria
dc.subject.otherImported disease
dc.subject.otherGauteng
dc.subject.otherInfection
dc.subject.otherParasitosis
dc.subject.otherProtozoal disease
dc.subject.otherAfrica
dc.subject.otherSouth Africa
dc.subject.otherMédecine tropicale
dc.subject.otherMédecine des voyages
dc.subject.otherPaludisme
dc.subject.otherMaladie d'importation
dc.subject.otherParasitose
dc.subject.otherProtozoose
dc.subject.otherAfrique
dc.subject.otherAfrique du Sud
dc.subject.otherMedicina tropical
dc.subject.otherMedicina para el viajero
dc.subject.otherPaludismo
dc.subject.otherEnfermedad de importación
dc.subject.otherInfección
dc.subject.otherProtozoosis
dc.subject.otherSudáfrica
dc.titleThe burden of imported malaria in Gauteng Province
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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