The association between aids related stigma and major depressive disorder among HIV-positive individuals in Uganda

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dc.contributor.authorAkena, Dickensen_ZA
dc.contributor.authorMusisi, Segganeen_ZA
dc.contributor.authorJoska, Johnen_ZA
dc.contributor.authorStein, Dan Jen_ZA
dc.date.accessioned2015-11-23T12:37:50Z
dc.date.available2015-11-23T12:37:50Z
dc.date.issued2012en_ZA
dc.description.abstractBACKGROUND: Major depressive disorder in people living with HIV/AIDS (PLWHA) is common and may be associated with a number of factors, including AIDS-related stigma, decreased CD4 levels, increased opportunistic infections and sociodemographic variables. The extent to which AIDS-related stigma is associated with major depressive disorder among PLWHA has not been well studied in sub-Saharan Africa. The objective of this study was to examine the associations between major depressive disorder, AIDS-related stigma, immune status, and sociodemographic variables with the aim of making recommendations that can guide clinicians. METHODS: We assessed 368 PLWHA for major depressive disorder, as well as for potentially associated factors, including AIDS-related stigma, CD4 levels, presence of opportunistic infections, and sociodemographic variables. RESULTS: The prevalence of major depressive disorder was 17.4%, while 7.9% of the participants had AIDS related stigma. At multivariable analysis, major depressive disorder was significantly associated with AIDS-related stigma [OR = 1.65, CI (1.20-2.26)], a CD4 count of ≥200 [OR 0.52 CI (0.27-0.99)], and being of younger age [0.95, CI (0.92-0.98). CONCLUSIONS: Due to the high burden of major depressive disorder, and its association with AIDS related stigma, routine screening of PLWHA for both conditions is recommended. However, more research is required to understand this association.en_ZA
dc.identifier.apacitationAkena, D., Musisi, S., Joska, J., & Stein, D. J. (2012). The association between aids related stigma and major depressive disorder among HIV-positive individuals in Uganda. <i>PLoS One</i>, http://hdl.handle.net/11427/15358en_ZA
dc.identifier.chicagocitationAkena, Dickens, Seggane Musisi, John Joska, and Dan J Stein "The association between aids related stigma and major depressive disorder among HIV-positive individuals in Uganda." <i>PLoS One</i> (2012) http://hdl.handle.net/11427/15358en_ZA
dc.identifier.citationAkena, D., Musisi, S., Joska, J., & Stein, D. J. (2011). The association between aids related stigma and major depressive disorder among HIV-positive individuals in Uganda. PloS one, 7(11), e48671. doi:10.1371/journal.pone.0048671en_ZA
dc.identifier.ris TY - Journal Article AU - Akena, Dickens AU - Musisi, Seggane AU - Joska, John AU - Stein, Dan J AB - BACKGROUND: Major depressive disorder in people living with HIV/AIDS (PLWHA) is common and may be associated with a number of factors, including AIDS-related stigma, decreased CD4 levels, increased opportunistic infections and sociodemographic variables. The extent to which AIDS-related stigma is associated with major depressive disorder among PLWHA has not been well studied in sub-Saharan Africa. The objective of this study was to examine the associations between major depressive disorder, AIDS-related stigma, immune status, and sociodemographic variables with the aim of making recommendations that can guide clinicians. METHODS: We assessed 368 PLWHA for major depressive disorder, as well as for potentially associated factors, including AIDS-related stigma, CD4 levels, presence of opportunistic infections, and sociodemographic variables. RESULTS: The prevalence of major depressive disorder was 17.4%, while 7.9% of the participants had AIDS related stigma. At multivariable analysis, major depressive disorder was significantly associated with AIDS-related stigma [OR = 1.65, CI (1.20-2.26)], a CD4 count of ≥200 [OR 0.52 CI (0.27-0.99)], and being of younger age [0.95, CI (0.92-0.98). CONCLUSIONS: Due to the high burden of major depressive disorder, and its association with AIDS related stigma, routine screening of PLWHA for both conditions is recommended. However, more research is required to understand this association. DA - 2012 DB - OpenUCT DO - 10.1371/journal.pone.0048671 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - The association between aids related stigma and major depressive disorder among HIV-positive individuals in Uganda TI - The association between aids related stigma and major depressive disorder among HIV-positive individuals in Uganda UR - http://hdl.handle.net/11427/15358 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15358
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0048671
dc.identifier.vancouvercitationAkena D, Musisi S, Joska J, Stein DJ. The association between aids related stigma and major depressive disorder among HIV-positive individuals in Uganda. PLoS One. 2012; http://hdl.handle.net/11427/15358.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDepartment of Psychiatry and Mental Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2012 Akena et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherDepressionen_ZA
dc.subject.otherAIDSen_ZA
dc.subject.otherHIVen_ZA
dc.subject.otherOpportunistic infectionsen_ZA
dc.subject.otherBivariate analysisen_ZA
dc.subject.otherAfricaen_ZA
dc.subject.otherAntiretroviral therapyen_ZA
dc.subject.otherQuality of lifeen_ZA
dc.titleThe association between aids related stigma and major depressive disorder among HIV-positive individuals in Ugandaen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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