In Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africa

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dc.contributor.advisorFolb, Peter Ien_ZA
dc.contributor.advisorShephard, Een_ZA
dc.contributor.authorQodi, Noluntuen_ZA
dc.date.accessioned2014-07-29T09:09:42Z
dc.date.available2014-07-29T09:09:42Z
dc.date.issued2001en_ZA
dc.descriptionBibliography: leaves 78-80.
dc.description.abstractUsing the ethno-medicinal data approach, nine South African plants used traditionally in the treatment of malaria were collected and evaluated for cytotoxic and lymphocyte-proliferating effects. These included Acokanthera oppositofolia, Zanthoxylum capense, Glycyrrhiza glabra, Harpephyllum caffrum, Lippia javanica, Pentanisia prunneloides, Psidium guajava, Typha capensis and Cannabis sativa. The cytotoxic effect of the aqueous, methanol and dichloromethane extracts of these plants was evaluated in vitro in Rat-1 fibroblasts there was no observable difference in cytotoxic activity between cold-and hot-water extracts of all the plants investigated. Cell proliferation greater than 80% was observed for aqueous extracts of A. oppositofolia, H. caffrum, L. javanica, P. prunneloides, P. guajava and T. capensis which would suggest are considered safe for consumption. However, high cytotoxic effect was exhibited by dichloromethane extracts of Z. capense, L. javanica, C. sativa and P. guajava at 100 μg/ml. These findings suggest that dichloromethane extracted compounds that are not normally extractable by traditional methods.en_ZA
dc.identifier.apacitationQodi, N. (2001). <i>In Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africa</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/3454en_ZA
dc.identifier.chicagocitationQodi, Noluntu. <i>"In Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africa."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2001. http://hdl.handle.net/11427/3454en_ZA
dc.identifier.citationQodi, N. 2001. In Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africa. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Qodi, Noluntu AB - Using the ethno-medicinal data approach, nine South African plants used traditionally in the treatment of malaria were collected and evaluated for cytotoxic and lymphocyte-proliferating effects. These included Acokanthera oppositofolia, Zanthoxylum capense, Glycyrrhiza glabra, Harpephyllum caffrum, Lippia javanica, Pentanisia prunneloides, Psidium guajava, Typha capensis and Cannabis sativa. The cytotoxic effect of the aqueous, methanol and dichloromethane extracts of these plants was evaluated in vitro in Rat-1 fibroblasts there was no observable difference in cytotoxic activity between cold-and hot-water extracts of all the plants investigated. Cell proliferation greater than 80% was observed for aqueous extracts of A. oppositofolia, H. caffrum, L. javanica, P. prunneloides, P. guajava and T. capensis which would suggest are considered safe for consumption. However, high cytotoxic effect was exhibited by dichloromethane extracts of Z. capense, L. javanica, C. sativa and P. guajava at 100 μg/ml. These findings suggest that dichloromethane extracted compounds that are not normally extractable by traditional methods. DA - 2001 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2001 T1 - In Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africa TI - In Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africa UR - http://hdl.handle.net/11427/3454 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3454
dc.identifier.vancouvercitationQodi N. In Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africa. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2001 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3454en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleIn Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africaen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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