The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection

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dc.contributor.advisorRyffel, Bernharden_ZA
dc.contributor.authorAbel, Brainen_ZA
dc.date.accessioned2017-12-08T13:56:14Z
dc.date.available2017-12-08T13:56:14Z
dc.date.issued2002en_ZA
dc.description.abstractThe aim of this study was to investigate the role of PRRs, namely TLR4 and LBP in vivo in the development of an immune response to a Mycobacterium tuberculosis infection. Mice with null mutations of the endotoxin receptors LBP and TLR4 were compared with wild-type mice (PRRs intact) in the context of an aerosol Mtb infection. The following questions were posed: Are the PRR-disrupted animals more susceptible to M.tuberculosis infection? What role do these PRRs play in inflammatory processes and in the development of granuloma? What role do the PRRs play in driving cytokine and chemokine response? Specifically, the following mice were infected aerogenically with Mtb H37Rv to further investigate their roles in vivo in mounting an effective immune response: C3H/HeN and C3H/ HeJ (TLR4 mutant) LBP+/+ and LBP-/-en_ZA
dc.identifier.apacitationAbel, B. (2002). <i>The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Immunology. Retrieved from http://hdl.handle.net/11427/26514en_ZA
dc.identifier.chicagocitationAbel, Brain. <i>"The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2002. http://hdl.handle.net/11427/26514en_ZA
dc.identifier.citationAbel, B. 2002. The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Abel, Brain AB - The aim of this study was to investigate the role of PRRs, namely TLR4 and LBP in vivo in the development of an immune response to a Mycobacterium tuberculosis infection. Mice with null mutations of the endotoxin receptors LBP and TLR4 were compared with wild-type mice (PRRs intact) in the context of an aerosol Mtb infection. The following questions were posed: Are the PRR-disrupted animals more susceptible to M.tuberculosis infection? What role do these PRRs play in inflammatory processes and in the development of granuloma? What role do the PRRs play in driving cytokine and chemokine response? Specifically, the following mice were infected aerogenically with Mtb H37Rv to further investigate their roles in vivo in mounting an effective immune response: C3H/HeN and C3H/ HeJ (TLR4 mutant) LBP+/+ and LBP-/- DA - 2002 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2002 T1 - The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection TI - The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection UR - http://hdl.handle.net/11427/26514 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/26514
dc.identifier.vancouvercitationAbel B. The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2002 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/26514en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherImmunologyen_ZA
dc.titleThe role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infectionen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMSc (Med)en_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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