Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups

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dc.contributor.authorDissanayeke, Shobana Rebeccaen_ZA
dc.contributor.authorLevin, Samuelen_ZA
dc.contributor.authorPienaar, Sandraen_ZA
dc.contributor.authorWood, Kathrynen_ZA
dc.contributor.authorEley, Brianen_ZA
dc.contributor.authorBeatty, Daviden_ZA
dc.contributor.authorHenderson, Howarden_ZA
dc.contributor.authorAnderson, Suzanneen_ZA
dc.contributor.authorLevin, Michaelen_ZA
dc.date.accessioned2016-01-11T06:56:41Z
dc.date.available2016-01-11T06:56:41Z
dc.date.issued2009en_ZA
dc.description.abstractHost recognition of mycobacterial surface molecules occurs through toll like receptors (TLR) 2 and 6. The adaptor protein TIRAP mediates down stream signalling of TLR2 and 4, and polymorphisms in the TIRAP gene ( TIRAP ) have been associated with susceptibility and resistance to tuberculosis (TB) in adults. In order to investigate the role of polymorphic variation in TIRAP in childhood TB in South Africa, which has one of the highest TB incidence rates in the world, we screened the entire open reading frame of TIRAP for sequence variation in two cohorts of childhood TB from different ethnic groups (Xhosa and mixed ancestry). We identified 13 SNPs, including seven previously unreported, in the two cohorts, and found significant differences in frequency of the variants between the two ethnic groups. No differences in frequency between individual SNPs or combinations were found between TB cases and controls in either cohort. However the 558C→T SNP previously associated with TB meningitis (TBM) in a Vietnamese population was found to be associated with TBM in the mixed ancestry group. Polymorphisms in TIRAP do not appear to be involved in childhood TB susceptibility in South Africa, but may play a role in determining occurrence of TBM.en_ZA
dc.identifier.apacitationDissanayeke, S. R., Levin, S., Pienaar, S., Wood, K., Eley, B., Beatty, D., ... Levin, M. (2009). Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups. <i>PLoS One</i>, http://hdl.handle.net/11427/16315en_ZA
dc.identifier.chicagocitationDissanayeke, Shobana Rebecca, Samuel Levin, Sandra Pienaar, Kathryn Wood, Brian Eley, David Beatty, Howard Henderson, Suzanne Anderson, and Michael Levin "Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups." <i>PLoS One</i> (2009) http://hdl.handle.net/11427/16315en_ZA
dc.identifier.citationDissanayeke, S. R., Levin, S., Pienaar, S., Wood, K., Eley, B., Beatty, D., ... & Levin, M. (2009). Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups. PLoS One, 4(8), e6698. doi:10.1371/journal.pone.0006698en_ZA
dc.identifier.ris TY - Journal Article AU - Dissanayeke, Shobana Rebecca AU - Levin, Samuel AU - Pienaar, Sandra AU - Wood, Kathryn AU - Eley, Brian AU - Beatty, David AU - Henderson, Howard AU - Anderson, Suzanne AU - Levin, Michael AB - Host recognition of mycobacterial surface molecules occurs through toll like receptors (TLR) 2 and 6. The adaptor protein TIRAP mediates down stream signalling of TLR2 and 4, and polymorphisms in the TIRAP gene ( TIRAP ) have been associated with susceptibility and resistance to tuberculosis (TB) in adults. In order to investigate the role of polymorphic variation in TIRAP in childhood TB in South Africa, which has one of the highest TB incidence rates in the world, we screened the entire open reading frame of TIRAP for sequence variation in two cohorts of childhood TB from different ethnic groups (Xhosa and mixed ancestry). We identified 13 SNPs, including seven previously unreported, in the two cohorts, and found significant differences in frequency of the variants between the two ethnic groups. No differences in frequency between individual SNPs or combinations were found between TB cases and controls in either cohort. However the 558C→T SNP previously associated with TB meningitis (TBM) in a Vietnamese population was found to be associated with TBM in the mixed ancestry group. Polymorphisms in TIRAP do not appear to be involved in childhood TB susceptibility in South Africa, but may play a role in determining occurrence of TBM. DA - 2009 DB - OpenUCT DO - 10.1371/journal.pone.0006698 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups TI - Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups UR - http://hdl.handle.net/11427/16315 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16315
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0006698
dc.identifier.vancouvercitationDissanayeke SR, Levin S, Pienaar S, Wood K, Eley B, Beatty D, et al. Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups. PLoS One. 2009; http://hdl.handle.net/11427/16315.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDepartment of Paediatrics and Child Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2009 Dissanayeke et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherTuberculosisen_ZA
dc.subject.otherMycobacterium tuberculosisen_ZA
dc.subject.otherEthnic epidemiologyen_ZA
dc.subject.otherChildrenen_ZA
dc.subject.otherToll-like receptorsen_ZA
dc.subject.otherAfricansen_ZA
dc.subject.otherBlooden_ZA
dc.subject.otherImmune receptor signalingen_ZA
dc.titlePolymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groupsen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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