The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice

Simple item page
dc.contributor.authorMagez, Stefanen_ZA
dc.contributor.authorSchwegmann, Anitaen_ZA
dc.contributor.authorAtkinson, Roberten_ZA
dc.contributor.authorClaes, Filipen_ZA
dc.contributor.authorDrennan, Michaelen_ZA
dc.contributor.authorDe Baetselier, Patricken_ZA
dc.contributor.authorBrombacher, Franken_ZA
dc.date.accessioned2015-11-23T12:35:22Z
dc.date.available2015-11-23T12:35:22Z
dc.date.issued2008en_ZA
dc.description.abstractAuthor Summary African trypanosomiasis is a disease caused by different species of extracellular flagellated protozoan trypanosome parasites. Trypanosomes have developed a mechanism of regular antigenic variation of their variant-specific surface glycoprotein (VSG) coat which allows chronic infection. Replacement of this coat occurs at rapid regular time intervals, allowing the parasite to escape from an effective host antibody responses. So far, primary T-cell independent antibody responses have been described to constitute the main host defense mechanism, relying largely on IgM antibody induction. Using genetically engineered B lymphocyte- or IgM-deficient mouse strains, we show that lack of B-cells or IgM did not prevent infection-associated anemia. More importantly, we show that in the absence of IgM, parasitemia was controlled almost as well as in wild-type mice, with only slightly increased mortality. In addition, we show in vivo that antigenic variation is not affected by the lack of IgM.en_ZA
dc.identifier.apacitationMagez, S., Schwegmann, A., Atkinson, R., Claes, F., Drennan, M., De Baetselier, P., & Brombacher, F. (2008). The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice. <i>PLoS One</i>, http://hdl.handle.net/11427/15326en_ZA
dc.identifier.chicagocitationMagez, Stefan, Anita Schwegmann, Robert Atkinson, Filip Claes, Michael Drennan, Patrick De Baetselier, and Frank Brombacher "The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice." <i>PLoS One</i> (2008) http://hdl.handle.net/11427/15326en_ZA
dc.identifier.citationMagez, S., Schwegmann, A., Atkinson, R., Claes, F., Drennan, M., De Baetselier, P., & Brombacher, F. (2008). The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice. PLoS Pathog, 4(8), e1000122. doi:10.1371/journal.ppat.1000122en_ZA
dc.identifier.ris TY - Journal Article AU - Magez, Stefan AU - Schwegmann, Anita AU - Atkinson, Robert AU - Claes, Filip AU - Drennan, Michael AU - De Baetselier, Patrick AU - Brombacher, Frank AB - Author Summary African trypanosomiasis is a disease caused by different species of extracellular flagellated protozoan trypanosome parasites. Trypanosomes have developed a mechanism of regular antigenic variation of their variant-specific surface glycoprotein (VSG) coat which allows chronic infection. Replacement of this coat occurs at rapid regular time intervals, allowing the parasite to escape from an effective host antibody responses. So far, primary T-cell independent antibody responses have been described to constitute the main host defense mechanism, relying largely on IgM antibody induction. Using genetically engineered B lymphocyte- or IgM-deficient mouse strains, we show that lack of B-cells or IgM did not prevent infection-associated anemia. More importantly, we show that in the absence of IgM, parasitemia was controlled almost as well as in wild-type mice, with only slightly increased mortality. In addition, we show in vivo that antigenic variation is not affected by the lack of IgM. DA - 2008 DB - OpenUCT DO - 10.1371/journal.ppat.1000122 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice TI - The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice UR - http://hdl.handle.net/11427/15326 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15326
dc.identifier.urihttp://dx.doi.org/10.1371/journal.ppat.1000122
dc.identifier.vancouvercitationMagez S, Schwegmann A, Atkinson R, Claes F, Drennan M, De Baetselier P, et al. The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice. PLoS One. 2008; http://hdl.handle.net/11427/15326.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2008 Magez et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plospathogensen_ZA
dc.subject.otherParasitic diseasesen_ZA
dc.subject.otherAntibodiesen_ZA
dc.subject.otherB cellsen_ZA
dc.subject.otherHost-pathogen interactionsen_ZA
dc.subject.otherParasitemiaen_ZA
dc.subject.otherAnemiaen_ZA
dc.subject.otherTrypanosoma brucei gambienseen_ZA
dc.subject.otherTrypanosomiasisen_ZA
dc.titleThe role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected miceen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Magez_Role_of_B_cells_and_IgM_Antibodies_2008.pdf
Size:
413.87 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles