Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections

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dc.contributor.advisorMaartens, Garyen_ZA
dc.contributor.advisorCohen, Karenen_ZA
dc.contributor.authorGounden, Ronalden_ZA
dc.date.accessioned2014-07-28T18:18:57Z
dc.date.available2014-07-28T18:18:57Z
dc.date.issued2009en_ZA
dc.descriptionIncludes bibliographical references (leaves 42-47).
dc.description.abstractBackground: Nosocomial infections due to multi-drug resistant Acinetobacter baumannii are often treated with colistin, but there are few data comparing its safety and effectiveness with other antimicrobials, particularly the aminoglycosides. Metbods: A retrospective cohort study of patients treated with colistin or tobramycin for A. baumannii infections in intensive care units (ICUs) at Groote Schuur hospital was performed. Colistin was used for A baumannii isolates which were resistant to all other available antimicrobials. Tobramycin was used when the organism was susceptible to this antimicrobial. We assessed and compared ICU mortality, nephrotoxicity and time to the first negative culture in the colistin and tobramycin groups.en_ZA
dc.identifier.apacitationGounden, R. (2009). <i>Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology. Retrieved from http://hdl.handle.net/11427/3282en_ZA
dc.identifier.chicagocitationGounden, Ronald. <i>"Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2009. http://hdl.handle.net/11427/3282en_ZA
dc.identifier.citationGounden, R. 2009. Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Gounden, Ronald AB - Background: Nosocomial infections due to multi-drug resistant Acinetobacter baumannii are often treated with colistin, but there are few data comparing its safety and effectiveness with other antimicrobials, particularly the aminoglycosides. Metbods: A retrospective cohort study of patients treated with colistin or tobramycin for A. baumannii infections in intensive care units (ICUs) at Groote Schuur hospital was performed. Colistin was used for A baumannii isolates which were resistant to all other available antimicrobials. Tobramycin was used when the organism was susceptible to this antimicrobial. We assessed and compared ICU mortality, nephrotoxicity and time to the first negative culture in the colistin and tobramycin groups. DA - 2009 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections TI - Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections UR - http://hdl.handle.net/11427/3282 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3282
dc.identifier.vancouvercitationGounden R. Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2009 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3282en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Clinical Pharmacologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherClinical Pharmacologyen_ZA
dc.titleSafety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infectionsen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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