High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa

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dc.contributor.authorEbrahim, Sumayyahen_ZA
dc.contributor.authorMndende, Xolani Ken_ZA
dc.contributor.authorKharsany, Ayesha B Men_ZA
dc.contributor.authorMbulawa, Zizipho Z Aen_ZA
dc.contributor.authorNaranbhai, Viveken_ZA
dc.contributor.authorFrohlich, Janeten_ZA
dc.contributor.authorWerner, Liseen_ZA
dc.contributor.authorSamsunder, Natashaen_ZA
dc.contributor.authorKarim, Quarraisha Abdoolen_ZA
dc.contributor.authorWilliamson, Anna-Liseen_ZA
dc.date.accessioned2016-02-10T14:44:57Z
dc.date.available2016-02-10T14:44:57Z
dc.date.issued2016en_ZA
dc.description.abstractObjectives HPV infection causes cervical cancer, yet information on prevalence and risk factors for HPV in Africa remain sparse. This study describes the prevalence of HPV genotypes and risk factors associated with HPV among young women ≤ 30 years of age in KwaZulu-Natal (KZN), South Africa. METHODS: Cervicovaginal lavage samples were tested for HPV genotypes in 224 women enrolled in a prospective cohort study. Clinical, behavioural and demographic data were collected. We measured prevalence of HPV genotypes and using logistic regression, examined for factors associated with HPV. RESULTS: Median age of participants was 21 years [interquartile range (IQR):18-23]. The overall prevalence of HPV was 76.3% (171/224) with multiple and single genotypes prevalent in 56.3% and 20.1% of women respectively. Proportion of women with high-risk genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56 and 58) was 54.5%. Women not living with their partner [adjusted odds ratio (aOR)] = 3.42 95% CI1.22-9.60; p = 0.019), was significantly associated with HPV infection and high-risk HPV genotype infection. CONCLUSION: The high burden of HPV and associated risk behaviours highlight the need to intensify behavioural interventions to prevent HPV acquisition in young women. The large scale delivery of HPV vaccine should be prioritised to prevent HPV acquisition and reduce HPV-related morbidity.en_ZA
dc.identifier.apacitationEbrahim, S., Mndende, X. K., Kharsany, A. B. M., Mbulawa, Z. Z. A., Naranbhai, V., Frohlich, J., ... Williamson, A. (2016). High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa. <i>PLoS One</i>, http://hdl.handle.net/11427/16941en_ZA
dc.identifier.chicagocitationEbrahim, Sumayyah, Xolani K Mndende, Ayesha B M Kharsany, Zizipho Z A Mbulawa, Vivek Naranbhai, Janet Frohlich, Lise Werner, Natasha Samsunder, Quarraisha Abdool Karim, and Anna-Lise Williamson "High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa." <i>PLoS One</i> (2016) http://hdl.handle.net/11427/16941en_ZA
dc.identifier.citationEbrahim, S., Mndende, X. K., Kharsany, A. B., Mbulawa, Z. Z., Naranbhai, V., Frohlich, J., ... & Williamson, A. L. (2016). High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa. PloS one, 11(1). doi:10.1371/journal.pone.0146603en_ZA
dc.identifier.ris TY - Journal Article AU - Ebrahim, Sumayyah AU - Mndende, Xolani K AU - Kharsany, Ayesha B M AU - Mbulawa, Zizipho Z A AU - Naranbhai, Vivek AU - Frohlich, Janet AU - Werner, Lise AU - Samsunder, Natasha AU - Karim, Quarraisha Abdool AU - Williamson, Anna-Lise AB - Objectives HPV infection causes cervical cancer, yet information on prevalence and risk factors for HPV in Africa remain sparse. This study describes the prevalence of HPV genotypes and risk factors associated with HPV among young women ≤ 30 years of age in KwaZulu-Natal (KZN), South Africa. METHODS: Cervicovaginal lavage samples were tested for HPV genotypes in 224 women enrolled in a prospective cohort study. Clinical, behavioural and demographic data were collected. We measured prevalence of HPV genotypes and using logistic regression, examined for factors associated with HPV. RESULTS: Median age of participants was 21 years [interquartile range (IQR):18-23]. The overall prevalence of HPV was 76.3% (171/224) with multiple and single genotypes prevalent in 56.3% and 20.1% of women respectively. Proportion of women with high-risk genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56 and 58) was 54.5%. Women not living with their partner [adjusted odds ratio (aOR)] = 3.42 95% CI1.22-9.60; p = 0.019), was significantly associated with HPV infection and high-risk HPV genotype infection. CONCLUSION: The high burden of HPV and associated risk behaviours highlight the need to intensify behavioural interventions to prevent HPV acquisition in young women. The large scale delivery of HPV vaccine should be prioritised to prevent HPV acquisition and reduce HPV-related morbidity. DA - 2016 DB - OpenUCT DO - 10.1371/journal.pone.0146603 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa TI - High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa UR - http://hdl.handle.net/11427/16941 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0146603en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16941
dc.identifier.vancouvercitationEbrahim S, Mndende XK, Kharsany ABM, Mbulawa ZZA, Naranbhai V, Frohlich J, et al. High burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africa. PLoS One. 2016; http://hdl.handle.net/11427/16941.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDivision of Virologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2016 Ebrahim et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherHuman papillomavirus infectionen_ZA
dc.subject.otherVaccinesen_ZA
dc.subject.otherHuman papillomavirusen_ZA
dc.subject.otherSexually transmitted diseasesen_ZA
dc.subject.otherCervical canceren_ZA
dc.subject.otherCopulationen_ZA
dc.subject.otherHuman sexual behavioren_ZA
dc.subject.otherSouth Africaen_ZA
dc.titleHigh burden of human papillomavirus (HPV) infection among young women in KwaZulu-Natal, South Africaen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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