The prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1)

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dc.contributor.advisorMaartens, Garyen_ZA
dc.contributor.advisorEhrlich, Rodneyen_ZA
dc.contributor.authorBadri, Motasim Hassan Yousofen_ZA
dc.date.accessioned2017-11-16T14:03:01Z
dc.date.available2017-11-16T14:03:01Z
dc.date.issued1999en_ZA
dc.date.updated2017-04-19T14:15:18Z
dc.description.abstractObjectives: The primary objective of this study was to assess whether active tuberculosis (TB) accelerates the course of HIV-1 infection by measuring progression to AIDS and mortality in HIV-infected patients. Secondary objectives were to evaluate whether TB should be considered an AIDS-defining illness in an area with a high prevalence of TB, and to assess the risk factors for developing TB in HIV-1 infected patients. Setting: New Somerset and Groote Schuur Hospital adult HIV clinics, Department of Medicine, Faculty of Health Sciences, University of Cape Town. Design: Prospective patient cohort study with five years of follow-up. Sample: Adult HIV-infected patients presenting to the two HIV clinics between 1992 and 1996. Methods: The TB case definition was a positive culture or a compatible clinical picture combined with a positive smear or a histologic diagnosis. TB patients were treated with 6-month short course regimens. The Kaplan-Meier method was used to estimate the overall survival times of tuberculosis and non-tuberculosis patients. The generalized log rank test was used to compare the survival curves of these two groups. The Cox proportional hazards regression method was used to determine the risk of death associated with tuberculosis while adjusting for potential confounding variables (i.e. age, CD4+ count, history of an AIDS-defining illness, use of co-trimoxazole prophylaxis, and antiretroviral therapy, etc.). The Kaplan-Meier method was used to evaluate the prognosis of HIV-infected patients with TB vs the prognosis of HIV-infected with other HIV ( or AIDS, as defined by the WHO or the CDC staging systems) related diseases at baseline. The generalized log rank test was used to compare the survival curves of the TB group vs the other groups. Predictors of active TB in HIV-infected patients were assessed using univariate and multivariate logistic regression models.en_ZA
dc.identifier.apacitationBadri, M. H. Y. (1999). <i>The prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1)</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine. Retrieved from http://hdl.handle.net/11427/26340en_ZA
dc.identifier.chicagocitationBadri, Motasim Hassan Yousof. <i>"The prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1)."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 1999. http://hdl.handle.net/11427/26340en_ZA
dc.identifier.citationBadri, M. 1999. The prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1). University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Badri, Motasim Hassan Yousof AB - Objectives: The primary objective of this study was to assess whether active tuberculosis (TB) accelerates the course of HIV-1 infection by measuring progression to AIDS and mortality in HIV-infected patients. Secondary objectives were to evaluate whether TB should be considered an AIDS-defining illness in an area with a high prevalence of TB, and to assess the risk factors for developing TB in HIV-1 infected patients. Setting: New Somerset and Groote Schuur Hospital adult HIV clinics, Department of Medicine, Faculty of Health Sciences, University of Cape Town. Design: Prospective patient cohort study with five years of follow-up. Sample: Adult HIV-infected patients presenting to the two HIV clinics between 1992 and 1996. Methods: The TB case definition was a positive culture or a compatible clinical picture combined with a positive smear or a histologic diagnosis. TB patients were treated with 6-month short course regimens. The Kaplan-Meier method was used to estimate the overall survival times of tuberculosis and non-tuberculosis patients. The generalized log rank test was used to compare the survival curves of these two groups. The Cox proportional hazards regression method was used to determine the risk of death associated with tuberculosis while adjusting for potential confounding variables (i.e. age, CD4+ count, history of an AIDS-defining illness, use of co-trimoxazole prophylaxis, and antiretroviral therapy, etc.). The Kaplan-Meier method was used to evaluate the prognosis of HIV-infected patients with TB vs the prognosis of HIV-infected with other HIV ( or AIDS, as defined by the WHO or the CDC staging systems) related diseases at baseline. The generalized log rank test was used to compare the survival curves of the TB group vs the other groups. Predictors of active TB in HIV-infected patients were assessed using univariate and multivariate logistic regression models. DA - 1999 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1999 T1 - The prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1) TI - The prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1) UR - http://hdl.handle.net/11427/26340 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/26340
dc.identifier.vancouvercitationBadri MHY. The prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1). [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 1999 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/26340en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherCommunity Healthen_ZA
dc.titleThe prognosis of tuberculosis in adults infected with Human Immunodeficiency Virus (HIV-1)en_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetype
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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