Pigeon circoviruses display patterns of recombination, genomic secondary structure and selection similar to those of beak and feather disease viruses

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dc.contributor.authorStenzel, Tomasz
dc.contributor.authorPiasecki, Tomasz
dc.contributor.authorChrza˛stek, Klaudia
dc.contributor.authorJulian, Laurel
dc.contributor.authorMuhire, Brejnev M
dc.contributor.authorGolden, Michael
dc.contributor.authorMartin, Darren P
dc.contributor.authorVarsani, Arvind
dc.date.accessioned2016-08-11T14:19:10Z
dc.date.available2016-08-11T14:19:10Z
dc.date.issued2014
dc.date.updated2016-08-11T14:15:57Z
dc.description.abstractPigeon circovirus (PiCV) has a ~2 kb genome circular ssDNA genome. All but one of the known PiCV isolates have been found infecting pigeons in various parts of the world. In this study, we screened 324 swab and tissue samples from Polish pigeons and recovered 30 complete genomes, 16 of which came from birds displaying no obvious pathology. Together with 17 other publicly available PiCV complete genomes sampled throughout the Northern Hemisphere and Australia, we find that PiCV displays a similar degree of genetic diversity to that of the related psittacine-infecting circovirus species, beak and feather disease virus (BFDV). We show that, as is the case with its pathology and epidemiology, PiCV also displays patterns of recombination, genomic secondary structure and natural selection that are generally very similar to those of BFDV. It is likely that breeding facilities play a significant role in the emergence of new recombinant PiCV variants and given that ~50 % of the domestic pigeon population is infected subclinically, all pigeon breeding stocks should be screened routinely for this virus.en_ZA
dc.identifierhttp://dx.doi.org/ 10.1099/vir.0.063917-0
dc.identifier.apacitationStenzel, T., Piasecki, T., , Julian, L., Muhire, B. M., Golden, M., ... Varsani, A. (2014). Pigeon circoviruses display patterns of recombination, genomic secondary structure and selection similar to those of beak and feather disease viruses. <i>Journal of General Virology</i>, http://hdl.handle.net/11427/21199en_ZA
dc.identifier.chicagocitationStenzel, Tomasz, Tomasz Piasecki, , Laurel Julian, Brejnev M Muhire, Michael Golden, Darren P Martin, and Arvind Varsani "Pigeon circoviruses display patterns of recombination, genomic secondary structure and selection similar to those of beak and feather disease viruses." <i>Journal of General Virology</i> (2014) http://hdl.handle.net/11427/21199en_ZA
dc.identifier.citationStenzel, T., Piasecki, T., ChrzÄ…stek, K., Julian, L., Muhire, B. M., Golden, M., ... & Varsani, A. (2014). Pigeon circoviruses display patterns of recombination, genomic secondary structure and selection similar to those of Beak and feather disease viruses. Journal of General Virology, 95(6), 1338-1351.en_ZA
dc.identifier.issn0022-1317en_ZA
dc.identifier.ris TY - Journal Article AU - Stenzel, Tomasz AU - Piasecki, Tomasz AU - Chrza˛stek, Klaudia AU - Julian, Laurel AU - Muhire, Brejnev M AU - Golden, Michael AU - Martin, Darren P AU - Varsani, Arvind AB - Pigeon circovirus (PiCV) has a ~2 kb genome circular ssDNA genome. All but one of the known PiCV isolates have been found infecting pigeons in various parts of the world. In this study, we screened 324 swab and tissue samples from Polish pigeons and recovered 30 complete genomes, 16 of which came from birds displaying no obvious pathology. Together with 17 other publicly available PiCV complete genomes sampled throughout the Northern Hemisphere and Australia, we find that PiCV displays a similar degree of genetic diversity to that of the related psittacine-infecting circovirus species, beak and feather disease virus (BFDV). We show that, as is the case with its pathology and epidemiology, PiCV also displays patterns of recombination, genomic secondary structure and natural selection that are generally very similar to those of BFDV. It is likely that breeding facilities play a significant role in the emergence of new recombinant PiCV variants and given that ~50 % of the domestic pigeon population is infected subclinically, all pigeon breeding stocks should be screened routinely for this virus. DA - 2014 DB - OpenUCT DP - University of Cape Town J1 - Journal of General Virology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 SM - 0022-1317 T1 - Pigeon circoviruses display patterns of recombination, genomic secondary structure and selection similar to those of beak and feather disease viruses TI - Pigeon circoviruses display patterns of recombination, genomic secondary structure and selection similar to those of beak and feather disease viruses UR - http://hdl.handle.net/11427/21199 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/21199
dc.identifier.vancouvercitationStenzel T, Piasecki T, , Julian L, Muhire BM, Golden M, et al. Pigeon circoviruses display patterns of recombination, genomic secondary structure and selection similar to those of beak and feather disease viruses. Journal of General Virology. 2014; http://hdl.handle.net/11427/21199.en_ZA
dc.languageengen_ZA
dc.publisherMicrobiology Societyen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceJournal of General Virologyen_ZA
dc.source.urihttp://jgv.microbiologyresearch.org/content/journal/jgv
dc.titlePigeon circoviruses display patterns of recombination, genomic secondary structure and selection similar to those of beak and feather disease virusesen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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