Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes

Simple item page
dc.contributor.advisorCaira, Mino Ren_ZA
dc.contributor.authorDean, Pamela Maryen_ZA
dc.date.accessioned2014-08-13T14:26:10Z
dc.date.available2014-08-13T14:26:10Z
dc.date.issued2004en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractNon-steroidal anti-inflammatory drugs (NSAIDs) are used for the prevention of pain and inflammation. These symptoms are brought about by the action of biochemicals such as prostoglandins, which result from the conversion of a fatty acid, known as arachidonic acid, by the enzyme cyclooxygenase (COX) in the presence of oxygen. NSAIDs act on this biochemical pathway by inhibiting the COX enzyme, thereby exerting their analgesic effect. Since, however, the solubility and bioavailability of NSAIDs are generally poor, encapsulation of these drugs in cyclodextrins was attempted in order to alter their dissolution properties.en_ZA
dc.identifier.apacitationDean, P. M. (2004). <i>Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/6303en_ZA
dc.identifier.chicagocitationDean, Pamela Mary. <i>"Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2004. http://hdl.handle.net/11427/6303en_ZA
dc.identifier.citationDean, P. 2004. Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Dean, Pamela Mary AB - Non-steroidal anti-inflammatory drugs (NSAIDs) are used for the prevention of pain and inflammation. These symptoms are brought about by the action of biochemicals such as prostoglandins, which result from the conversion of a fatty acid, known as arachidonic acid, by the enzyme cyclooxygenase (COX) in the presence of oxygen. NSAIDs act on this biochemical pathway by inhibiting the COX enzyme, thereby exerting their analgesic effect. Since, however, the solubility and bioavailability of NSAIDs are generally poor, encapsulation of these drugs in cyclodextrins was attempted in order to alter their dissolution properties. DA - 2004 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2004 T1 - Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes TI - Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes UR - http://hdl.handle.net/11427/6303 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6303
dc.identifier.vancouvercitationDean PM. Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2004 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6303en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleStructural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexesen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_sci_2004_dean_p_m.pdf
Size:
8.91 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Masters