Isoniazid preventive therapy for tuberculosis in South Africa: An assessment of the local evidence base

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dc.contributor.authorWood, Robin
dc.contributor.authorBekker, Linda‐Gail
dc.date.accessioned2021-10-08T07:20:27Z
dc.date.available2021-10-08T07:20:27Z
dc.date.issued2014
dc.description.abstractWorldwide, South Africa (SA) has the worst tuberculosis (TB) epidemic. In SA, there are > 6.1 million people living with HIV (PLWH) and the country now has the largest antiretroviral treatment programme with > 2 million people receiving combination therapy. While there has been a marked recent decline in HIV-associated deaths, > 50% of TB cases still continue to be diagnosed in PWLH. The current TB control strategy based on passive case finding, chemotherapy of childhood TB contacts and directly observed therapy has clearly failed to control endemic TB in SA. Two recent meta-analyses have shown a > 60% reduction in TB in HIV-infected adults after isoniazid preventive therapy (IPT). SA has implemented the World Health Organization policy and IPT is now recommended for HIV-positive people for up to 36 months. Originally, there was only one SA study included in the evidence base supporting this policy, but subsequently four randomised controlled trials have been conducted in SA populations. These studies, together with local observational studies, are the subject of this local, evidence-based review.
dc.identifier.apacitationWood, R., & (2014). Isoniazid preventive therapy for tuberculosis in South Africa: An assessment of the local evidence base. <i>South African Medical Journal</i>, 104(3), 174 - 177. http://hdl.handle.net/11427/34923en_ZA
dc.identifier.chicagocitationWood, Robin, and "Isoniazid preventive therapy for tuberculosis in South Africa: An assessment of the local evidence base." <i>South African Medical Journal</i> 104, 3. (2014): 174 - 177. http://hdl.handle.net/11427/34923en_ZA
dc.identifier.citationWood, R. & 2014. Isoniazid preventive therapy for tuberculosis in South Africa: An assessment of the local evidence base. <i>South African Medical Journal.</i> 104(3):174 - 177. http://hdl.handle.net/11427/34923en_ZA
dc.identifier.issn0038-2469
dc.identifier.ris TY - Journal Article AU - Wood, Robin AU - Bekker, Linda‐Gail AB - Worldwide, South Africa (SA) has the worst tuberculosis (TB) epidemic. In SA, there are > 6.1 million people living with HIV (PLWH) and the country now has the largest antiretroviral treatment programme with > 2 million people receiving combination therapy. While there has been a marked recent decline in HIV-associated deaths, > 50% of TB cases still continue to be diagnosed in PWLH. The current TB control strategy based on passive case finding, chemotherapy of childhood TB contacts and directly observed therapy has clearly failed to control endemic TB in SA. Two recent meta-analyses have shown a > 60% reduction in TB in HIV-infected adults after isoniazid preventive therapy (IPT). SA has implemented the World Health Organization policy and IPT is now recommended for HIV-positive people for up to 36 months. Originally, there was only one SA study included in the evidence base supporting this policy, but subsequently four randomised controlled trials have been conducted in SA populations. These studies, together with local observational studies, are the subject of this local, evidence-based review. DA - 2014 DB - OpenUCT DP - University of Cape Town IS - 3 J1 - South African Medical Journal LK - https://open.uct.ac.za PY - 2014 SM - 0038-2469 T1 - Isoniazid preventive therapy for tuberculosis in South Africa: An assessment of the local evidence base TI - Isoniazid preventive therapy for tuberculosis in South Africa: An assessment of the local evidence base UR - http://hdl.handle.net/11427/34923 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34923
dc.identifier.vancouvercitationWood R, . Isoniazid preventive therapy for tuberculosis in South Africa: An assessment of the local evidence base. South African Medical Journal. 2014;104(3):174 - 177. http://hdl.handle.net/11427/34923.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceSouth African Medical Journal
dc.source.journalissue3
dc.source.journalvolume104
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.7196/SAMJ.7968
dc.subject.otherHumans
dc.subject.otherIsoniazid
dc.subject.otherRandomized Controlled Trials as Topic
dc.subject.otherSouth Africa
dc.subject.otherTuberculosis
dc.subject.otherIsoniazid
dc.titleIsoniazid preventive therapy for tuberculosis in South Africa: An assessment of the local evidence base
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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