Synthesis of aminomethylthiazole analogues for evaluation as antiplasmodial agents

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dc.contributor.advisorChibale, Kellyen_ZA
dc.contributor.authorCheuka, Peter Men_ZA
dc.date.accessioned2014-11-05T03:56:58Z
dc.date.available2014-11-05T03:56:58Z
dc.date.issued2014en_ZA
dc.descriptionIncludes bibliographical referencesen_ZA
dc.description.abstractThe World Health Organisation has estimated that about 219 million cases of malaria occurred in 2010 with an estimated 660,000 fatalities resulting. The disease is caused by five species of protozoan parasites of the genus Plasmodium with Plasmodium falciparum being the most virulent. Among the many shortfalls of current antimalarial drugs, the emergence of drug resistant strains of the malaria parasites is the most disturbing. Thus, there is an urgent need to develop new chemotherapeutic agents which can potentially target drug resistant strains of these parasites. Undertaking structure activity relationship (SAR) studies around biologically active compounds is one strategy that can identify analogues with superior activity and/or novel modes of action to circumvent drug resistance. In this dissertation, the synthesis, characterisation, and antiplasmodial evaluation of aminomethylthiazoles and related analogues are reported.en_ZA
dc.identifier.apacitationCheuka, P. M. (2014). <i>Synthesis of aminomethylthiazole analogues for evaluation as antiplasmodial agents</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/9199en_ZA
dc.identifier.chicagocitationCheuka, Peter M. <i>"Synthesis of aminomethylthiazole analogues for evaluation as antiplasmodial agents."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2014. http://hdl.handle.net/11427/9199en_ZA
dc.identifier.citationCheuka, P. 2014. Synthesis of aminomethylthiazole analogues for evaluation as antiplasmodial agents. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Cheuka, Peter M AB - The World Health Organisation has estimated that about 219 million cases of malaria occurred in 2010 with an estimated 660,000 fatalities resulting. The disease is caused by five species of protozoan parasites of the genus Plasmodium with Plasmodium falciparum being the most virulent. Among the many shortfalls of current antimalarial drugs, the emergence of drug resistant strains of the malaria parasites is the most disturbing. Thus, there is an urgent need to develop new chemotherapeutic agents which can potentially target drug resistant strains of these parasites. Undertaking structure activity relationship (SAR) studies around biologically active compounds is one strategy that can identify analogues with superior activity and/or novel modes of action to circumvent drug resistance. In this dissertation, the synthesis, characterisation, and antiplasmodial evaluation of aminomethylthiazoles and related analogues are reported. DA - 2014 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Synthesis of aminomethylthiazole analogues for evaluation as antiplasmodial agents TI - Synthesis of aminomethylthiazole analogues for evaluation as antiplasmodial agents UR - http://hdl.handle.net/11427/9199 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/9199
dc.identifier.vancouvercitationCheuka PM. Synthesis of aminomethylthiazole analogues for evaluation as antiplasmodial agents. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2014 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/9199en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.titleSynthesis of aminomethylthiazole analogues for evaluation as antiplasmodial agentsen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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