Is total glossectomy for advanced carcinoma of the tongue justified?
| dc.contributor.author | Van Lierop, Anton C | |
| dc.contributor.author | Basson, Ola | |
| dc.contributor.author | Fagan, Johannes J | |
| dc.date.accessioned | 2016-01-19T10:33:36Z | |
| dc.date.available | 2016-01-19T10:33:36Z | |
| dc.date.issued | 2008 | |
| dc.date.updated | 2016-01-19T07:18:10Z | |
| dc.description.abstract | Total glossectomy (with or without total laryngectomy) followed by postoperative radiotherapy remains the principal treatment method for advanced base of tongue carcinoma. The procedure remains controversial owing to poor cure rates and the inevitable functional deficits associated with it. However, even though total glossectomy is a major surgical procedure that impacts on speech, deglutition and quality of life, it may offer patients the best chance of cure in many centres, especially in the developing world. Methods: We did a retrospective chart review of all patients at Groote Schuur Hospital, Cape Town, who had undergone total glossectomy, with or without total laryngectomy, for stage IV squamous cell carcinoma (SCC) of the tongue between 1998 and 2004. Results: Eight patients had a total glossectomy performed during the study period. At 2, 3 and 5 years 63%, 38% and 25% of patients respectively were alive without disease. No patient required permanent nasogastric or gastrostomy feeding, and all returned to a full oral diet. Three of 5 patients who had laryngeal preservation and could be assessed for speech had intelligible speech. All but 1 patient (88%) reported pain relief following surgical excision. Perineural invasion was present in 75%, and 38% had positive resection margins. Five patients had recurrence, 2 cervical, 1 local, and 2 local and cervical. Conclusion: Advanced SCC of the tongue is a devastating disease causing severe pain and disorders of speech and swallowing. Total glossectomy (with or without total laryngectomy) and postoperative radiotherapy is a reasonable treatment option, particularly in the developing world setting. It has cure rates superior to primary radiotherapy, and provides motivated patients with excellent pain relief and a reasonable quality of life. | en_ZA |
| dc.identifier.apacitation | Van Lierop, A. C., Basson, O., & Fagan, J. J. (2008). Is total glossectomy for advanced carcinoma of the tongue justified?. <i>South African Journal of Surgery</i>, http://hdl.handle.net/11427/16426 | en_ZA |
| dc.identifier.chicagocitation | Van Lierop, Anton C, Ola Basson, and Johannes J Fagan "Is total glossectomy for advanced carcinoma of the tongue justified?." <i>South African Journal of Surgery</i> (2008) http://hdl.handle.net/11427/16426 | en_ZA |
| dc.identifier.citation | Van Lierop, A. C., Basson, O., & Fagan, J. J. (2008). Is total glossectomy for advanced carcinoma of the tongue justified?: head and neck surgery. South African Journal of Surgery, 46(1), 22-25. | en_ZA |
| dc.identifier.issn | 0038-2361 | en_ZA |
| dc.identifier.ris | TY - Journal Article AU - Van Lierop, Anton C AU - Basson, Ola AU - Fagan, Johannes J AB - Total glossectomy (with or without total laryngectomy) followed by postoperative radiotherapy remains the principal treatment method for advanced base of tongue carcinoma. The procedure remains controversial owing to poor cure rates and the inevitable functional deficits associated with it. However, even though total glossectomy is a major surgical procedure that impacts on speech, deglutition and quality of life, it may offer patients the best chance of cure in many centres, especially in the developing world. Methods: We did a retrospective chart review of all patients at Groote Schuur Hospital, Cape Town, who had undergone total glossectomy, with or without total laryngectomy, for stage IV squamous cell carcinoma (SCC) of the tongue between 1998 and 2004. Results: Eight patients had a total glossectomy performed during the study period. At 2, 3 and 5 years 63%, 38% and 25% of patients respectively were alive without disease. No patient required permanent nasogastric or gastrostomy feeding, and all returned to a full oral diet. Three of 5 patients who had laryngeal preservation and could be assessed for speech had intelligible speech. All but 1 patient (88%) reported pain relief following surgical excision. Perineural invasion was present in 75%, and 38% had positive resection margins. Five patients had recurrence, 2 cervical, 1 local, and 2 local and cervical. Conclusion: Advanced SCC of the tongue is a devastating disease causing severe pain and disorders of speech and swallowing. Total glossectomy (with or without total laryngectomy) and postoperative radiotherapy is a reasonable treatment option, particularly in the developing world setting. It has cure rates superior to primary radiotherapy, and provides motivated patients with excellent pain relief and a reasonable quality of life. DA - 2008 DB - OpenUCT DP - University of Cape Town J1 - South African Journal of Surgery LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 SM - 0038-2361 T1 - Is total glossectomy for advanced carcinoma of the tongue justified? TI - Is total glossectomy for advanced carcinoma of the tongue justified? UR - http://hdl.handle.net/11427/16426 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/16426 | |
| dc.identifier.vancouvercitation | Van Lierop AC, Basson O, Fagan JJ. Is total glossectomy for advanced carcinoma of the tongue justified?. South African Journal of Surgery. 2008; http://hdl.handle.net/11427/16426. | en_ZA |
| dc.language | eng | en_ZA |
| dc.publisher | Health and Medical Publishing Group | en_ZA |
| dc.publisher.department | Division of Otorhinolaryngology | en_ZA |
| dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.source | South African Journal of Surgery | en_ZA |
| dc.source.uri | http://www.sajs.org.za/index.php/sajs | |
| dc.title | Is total glossectomy for advanced carcinoma of the tongue justified? | en_ZA |
| dc.type | Journal Article | en_ZA |
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Article | en_ZA |