A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape
| dc.contributor.advisor | Beatty, David William | en_ZA |
| dc.contributor.author | Potgieter, Stephanus Theron | en_ZA |
| dc.date.accessioned | 2017-12-07T08:44:52Z | |
| dc.date.available | 2017-12-07T08:44:52Z | |
| dc.date.issued | 1997 | en_ZA |
| dc.date.updated | 2017-08-17T13:43:34Z | |
| dc.description.abstract | STUDY OBJECTIVES: An analysis of IgG subclasses and allotypes in children with pulmonary Tuberculosis (PTB) in the Western Cape. DESIGN: Consecutive children under 15 years of age with microbiological proven PTB over an 8 month period- November 1993 to July 1994. SETTING: Teaching Hospitals in Cape Town. PATIENTS: Thirty-five cases were selected from 99 consecutive cases that were Mycobacterium tuberculosis positive, 15 of which were of Mixed and 20 were of Black Ancestry. CONTROL GROUP: Sera were selected from 224 Black Ancestry (59 children and 165 adults) and 211 Mixed Ancestry (67 children and 144 adults) that had no evidence for active tuberculosis or a history of previous TB diagnosis. MEASUREMENTS AND RESULTS: IgG subclasses, total IgG,and five allotypes: Glm(a), Glm(f), G2m(n), G3m(bl), G3m(gl) were determined by ELISA techniques. In the Mixed ancestry group the Glm(f) (p= 0.01), G2m(n) (p= 0.04) and G3m(gl) (p=0.001) allotypes were less frequently found in children with proven PTB. In the Black Ancestry subjects the G3m(g 1) allotype was significantly less common than in the control group (p < 0.001). CONCLUSIONS: Because allotypes are inherited in a Mendelian fashion, the observed association of childhood PTB and certain allotypes strengthens the hypothesis that a genetic susceptibility exists to acquiring TB. | en_ZA |
| dc.identifier.apacitation | Potgieter, S. T. (1997). <i>A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Pulmonology. Retrieved from http://hdl.handle.net/11427/26487 | en_ZA |
| dc.identifier.chicagocitation | Potgieter, Stephanus Theron. <i>"A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Pulmonology, 1997. http://hdl.handle.net/11427/26487 | en_ZA |
| dc.identifier.citation | Potgieter, S. 1997. A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape. University of Cape Town. | en_ZA |
| dc.identifier.ris | TY - Thesis / Dissertation AU - Potgieter, Stephanus Theron AB - STUDY OBJECTIVES: An analysis of IgG subclasses and allotypes in children with pulmonary Tuberculosis (PTB) in the Western Cape. DESIGN: Consecutive children under 15 years of age with microbiological proven PTB over an 8 month period- November 1993 to July 1994. SETTING: Teaching Hospitals in Cape Town. PATIENTS: Thirty-five cases were selected from 99 consecutive cases that were Mycobacterium tuberculosis positive, 15 of which were of Mixed and 20 were of Black Ancestry. CONTROL GROUP: Sera were selected from 224 Black Ancestry (59 children and 165 adults) and 211 Mixed Ancestry (67 children and 144 adults) that had no evidence for active tuberculosis or a history of previous TB diagnosis. MEASUREMENTS AND RESULTS: IgG subclasses, total IgG,and five allotypes: Glm(a), Glm(f), G2m(n), G3m(bl), G3m(gl) were determined by ELISA techniques. In the Mixed ancestry group the Glm(f) (p= 0.01), G2m(n) (p= 0.04) and G3m(gl) (p=0.001) allotypes were less frequently found in children with proven PTB. In the Black Ancestry subjects the G3m(g 1) allotype was significantly less common than in the control group (p < 0.001). CONCLUSIONS: Because allotypes are inherited in a Mendelian fashion, the observed association of childhood PTB and certain allotypes strengthens the hypothesis that a genetic susceptibility exists to acquiring TB. DA - 1997 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1997 T1 - A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape TI - A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape UR - http://hdl.handle.net/11427/26487 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/26487 | |
| dc.identifier.vancouvercitation | Potgieter ST. A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Pulmonology, 1997 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/26487 | en_ZA |
| dc.language.iso | eng | en_ZA |
| dc.publisher.department | Division of Pulmonology | en_ZA |
| dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.subject.other | Pulmonary Tuberculosis | en_ZA |
| dc.title | A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape | en_ZA |
| dc.type | Master Thesis | |
| dc.type.qualificationlevel | Masters | |
| dc.type.qualificationname | MMed | en_ZA |
| uct.type.filetype | ||
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Thesis | en_ZA |