Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries

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dc.contributor.advisorLecour, Sandrineen_ZA
dc.contributor.advisorOpie, Lionel Hen_ZA
dc.contributor.authorKing, Jonathan Chanen_ZA
dc.date.accessioned2015-04-22T12:52:05Z
dc.date.available2015-04-22T12:52:05Z
dc.date.issued2011en_ZA
dc.description.abstractIntroduction: Sphingosine 1 phosphate (S1P) is a major constituent of high density lipoprotein (HDL) cholesterol. Both S1P preconditioning and ischaemic postconditioning reduce myocardial damage following an ischaemia-reperfusion insult but the mechanisms involved remain unclear. Janus kinase/Signal transducer and activator of transcription 3 (JAK/STAT-3) form part of a recently discovered powerful prosurvival path termed as the Survivor Activating Factor Enhancement (SAFE) pathway. The SAFE pathway plays a critical role in ischaemic preconditioning to promote cell survival but whether activation of STAT-3 is required for S1P preconditioning and ischaemic postconditioning induced cardioprotection is unknown. Hypothesis: Activation of the STAT-3 is required for S1P preconditioning and ischaemic postconditioning.en_ZA
dc.identifier.apacitationKing, J. C. (2011). <i>Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology. Retrieved from http://hdl.handle.net/11427/12692en_ZA
dc.identifier.chicagocitationKing, Jonathan Chan. <i>"Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology, 2011. http://hdl.handle.net/11427/12692en_ZA
dc.identifier.citationKing, J. 2011. Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - King, Jonathan Chan AB - Introduction: Sphingosine 1 phosphate (S1P) is a major constituent of high density lipoprotein (HDL) cholesterol. Both S1P preconditioning and ischaemic postconditioning reduce myocardial damage following an ischaemia-reperfusion insult but the mechanisms involved remain unclear. Janus kinase/Signal transducer and activator of transcription 3 (JAK/STAT-3) form part of a recently discovered powerful prosurvival path termed as the Survivor Activating Factor Enhancement (SAFE) pathway. The SAFE pathway plays a critical role in ischaemic preconditioning to promote cell survival but whether activation of STAT-3 is required for S1P preconditioning and ischaemic postconditioning induced cardioprotection is unknown. Hypothesis: Activation of the STAT-3 is required for S1P preconditioning and ischaemic postconditioning. DA - 2011 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries TI - Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries UR - http://hdl.handle.net/11427/12692 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12692
dc.identifier.vancouvercitationKing JC. Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology, 2011 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12692en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Cardiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPhysiologyen_ZA
dc.titleCardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuriesen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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