Cardiovascular risk status of Afro-origin populations across the spectrum of economic development: findings from the Modeling the Epidemiologic Transition Study

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dc.contributor.authorDugas, Lara R
dc.contributor.authorForrester, Terrence E
dc.contributor.authorPlange-Rhule, Jacob
dc.contributor.authorBovet, Pascal
dc.contributor.authorLambert, Estelle V
dc.contributor.authorDurazo-Arvizu, Ramon A
dc.contributor.authorCao, Guichan
dc.contributor.authorCooper, Richard S
dc.contributor.authorKhatib, Rasha
dc.contributor.authorTonino, Laura
dc.contributor.authorRiesen, Walter
dc.contributor.authorKorte, Wolfgang
dc.contributor.authorKliethermes, Stephanie
dc.contributor.authorLuke, Amy
dc.date.accessioned2017-06-23T08:44:55Z
dc.date.available2017-06-23T08:44:55Z
dc.date.issued2017-05-12
dc.date.updated2017-05-14T03:25:55Z
dc.description.abstractBackground: Cardiovascular risk factors are increasing in most developing countries. To date, however, very little standardized data has been collected on the primary risk factors across the spectrum of economic development. Data are particularly sparse from Africa. Methods: In the Modeling the Epidemiologic Transition Study (METS) we examined population-based samples of men and women, ages 25–45 of African ancestry in metropolitan Chicago, Kingston, Jamaica, rural Ghana, Cape Town, South Africa, and the Seychelles. Key measures of cardiovascular disease risk are described. Results: The risk factor profile varied widely in both total summary estimates of cardiovascular risk and in the magnitude of component factors. Hypertension ranged from 7% in women from Ghana to 35% in US men. Total cholesterol was well under 200 mg/dl for all groups, with a mean of 155 mg/dl among men in Ghana, South Africa and Jamaica. Among women total cholesterol values varied relatively little by country, following between 160 and 178 mg/dl for all 5 groups. Levels of HDL-C were virtually identical in men and women from all study sites. Obesity ranged from 64% among women in the US to 2% among Ghanaian men, with a roughly corresponding trend in diabetes. Based on the Framingham risk score a clear trend toward higher total risk in association with socioeconomic development was observed among men, while among women there was considerable overlap, with the US participants having only a modestly higher risk score. Conclusions: These data provide a comprehensive estimate of cardiovascular risk across a range of countries at differing stages of social and economic development and demonstrate the heterogeneity in the character and degree of emerging cardiovascular risk. Severe hypercholesterolemia, as characteristic in the US and much of Western Europe at the onset of the coronary epidemic, is unlikely to be a feature of the cardiovascular risk profile in these countries in the foreseeable future, suggesting that stroke may remain the dominant cardiovascular event.
dc.identifier.apacitationDugas, L. R., Forrester, T. E., Plange-Rhule, J., Bovet, P., Lambert, E. V., Durazo-Arvizu, R. A., ... Luke, A. (2017). Cardiovascular risk status of Afro-origin populations across the spectrum of economic development: findings from the Modeling the Epidemiologic Transition Study. <i>BMC Public Health</i>, http://hdl.handle.net/11427/24613en_ZA
dc.identifier.chicagocitationDugas, Lara R, Terrence E Forrester, Jacob Plange-Rhule, Pascal Bovet, Estelle V Lambert, Ramon A Durazo-Arvizu, Guichan Cao, et al "Cardiovascular risk status of Afro-origin populations across the spectrum of economic development: findings from the Modeling the Epidemiologic Transition Study." <i>BMC Public Health</i> (2017) http://hdl.handle.net/11427/24613en_ZA
dc.identifier.citationDugas, L. R., Forrester, T. E., Plange-Rhule, J., Bovet, P., Lambert, E. V., Durazo-Arvizu, R. A., ... & Riesen, W. (2017). Cardiovascular risk status of Afro-origin populations across the spectrum of economic development: findings from the Modeling the Epidemiologic Transition Study. BMC public health, 17(1), 438.
dc.identifier.ris TY - Journal Article AU - Dugas, Lara R AU - Forrester, Terrence E AU - Plange-Rhule, Jacob AU - Bovet, Pascal AU - Lambert, Estelle V AU - Durazo-Arvizu, Ramon A AU - Cao, Guichan AU - Cooper, Richard S AU - Khatib, Rasha AU - Tonino, Laura AU - Riesen, Walter AU - Korte, Wolfgang AU - Kliethermes, Stephanie AU - Luke, Amy AB - Background: Cardiovascular risk factors are increasing in most developing countries. To date, however, very little standardized data has been collected on the primary risk factors across the spectrum of economic development. Data are particularly sparse from Africa. Methods: In the Modeling the Epidemiologic Transition Study (METS) we examined population-based samples of men and women, ages 25–45 of African ancestry in metropolitan Chicago, Kingston, Jamaica, rural Ghana, Cape Town, South Africa, and the Seychelles. Key measures of cardiovascular disease risk are described. Results: The risk factor profile varied widely in both total summary estimates of cardiovascular risk and in the magnitude of component factors. Hypertension ranged from 7% in women from Ghana to 35% in US men. Total cholesterol was well under 200 mg/dl for all groups, with a mean of 155 mg/dl among men in Ghana, South Africa and Jamaica. Among women total cholesterol values varied relatively little by country, following between 160 and 178 mg/dl for all 5 groups. Levels of HDL-C were virtually identical in men and women from all study sites. Obesity ranged from 64% among women in the US to 2% among Ghanaian men, with a roughly corresponding trend in diabetes. Based on the Framingham risk score a clear trend toward higher total risk in association with socioeconomic development was observed among men, while among women there was considerable overlap, with the US participants having only a modestly higher risk score. Conclusions: These data provide a comprehensive estimate of cardiovascular risk across a range of countries at differing stages of social and economic development and demonstrate the heterogeneity in the character and degree of emerging cardiovascular risk. Severe hypercholesterolemia, as characteristic in the US and much of Western Europe at the onset of the coronary epidemic, is unlikely to be a feature of the cardiovascular risk profile in these countries in the foreseeable future, suggesting that stroke may remain the dominant cardiovascular event. DA - 2017-05-12 DB - OpenUCT DO - 10.1186/s12889-017-4318-4 DP - University of Cape Town J1 - BMC Public Health LK - https://open.uct.ac.za PB - University of Cape Town PY - 2017 T1 - Cardiovascular risk status of Afro-origin populations across the spectrum of economic development: findings from the Modeling the Epidemiologic Transition Study TI - Cardiovascular risk status of Afro-origin populations across the spectrum of economic development: findings from the Modeling the Epidemiologic Transition Study UR - http://hdl.handle.net/11427/24613 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1186/s12889-017-4318-4
dc.identifier.urihttp://hdl.handle.net/11427/24613
dc.identifier.vancouvercitationDugas LR, Forrester TE, Plange-Rhule J, Bovet P, Lambert EV, Durazo-Arvizu RA, et al. Cardiovascular risk status of Afro-origin populations across the spectrum of economic development: findings from the Modeling the Epidemiologic Transition Study. BMC Public Health. 2017; http://hdl.handle.net/11427/24613.en_ZA
dc.language.isoen
dc.publisherBioMed Central
dc.publisher.departmentMRC/UCT RU for Exercise and Sport Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rights.holderThe Author(s).
dc.sourceBMC Public Health
dc.source.urihttps://bmcpublichealth.biomedcentral.com/
dc.subject.otherAfrican diaspora
dc.subject.otherHuman development index
dc.subject.otherCardiovascular risk
dc.titleCardiovascular risk status of Afro-origin populations across the spectrum of economic development: findings from the Modeling the Epidemiologic Transition Study
dc.typeJournal Article
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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