Nutritional, immune, micronutrient and health status of HIV-infected children in care centres in Manguang

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dc.contributor.authorSteenkamp, L
dc.contributor.authorDannhauser, A
dc.contributor.authorWalsh, D
dc.contributor.authorJoubert, G
dc.contributor.authorVeldman, F J
dc.contributor.authorVan der Walt, E
dc.contributor.authorCox, C
dc.contributor.authorHendricks, M K
dc.contributor.authorDippenaar, H
dc.date.accessioned2017-05-29T11:25:57Z
dc.date.available2017-05-29T11:25:57Z
dc.date.issued2009
dc.date.updated2016-01-08T10:43:50Z
dc.description.abstractAim: To assess the nutritional, immune, micronutrient and health status of antiretroviral-naïve HIV-infected children. Method: A cross-sectional descriptive study was undertaken between September 2004 and March 2006 amongst HIV-infected children of which none received antiretroviral therapy, in care centres in Mangaung, Free State. Results: The study included 37 clinically stable and food-secure HIV-infected children. Their median age was 5.4 years (range 1.2–10.2 years). Fifteen children (41%) were underweight, 30 (81%) were stunted and one (3%) was wasted. The most commonly observed clinical features were lymphadenopathy (84%), skin rashes (51%), hepatomegaly (32%) and pallor (41%). Eight per cent of children had features of TB, while 19% had a lower respiratory tract infection. The median viral load of the group (n = 35) was 117 000 copies/ml, the median CD4+ cell count was 477 cells/mm3 and the median CD4 percentage was 22.5%. A significant negative correlation could be demonstrated between viral load and nutritional indicators. Children had deficient serum levels relative to normal reference values for glutathione (91% of children), albumin (78%), vitamin A (63%), vitamin D (44%), zinc (38%) and vitamin E (13%). Sixty per cent of the children were anaemic and 30% were iron deficient. Conclusion: A high prevalence of acute and chronic malnutrition and micronutrient deficiencies occurred among HIV-infected children residing in care centres. The study highlights the need to investigate early initiation of antiretroviral therapy and nutrition interventions, including aggressive supplementation, in order to improve the prognosis of these children.
dc.identifier.apacitationSteenkamp, L., Dannhauser, A., Walsh, D., Joubert, G., Veldman, F. J., Van der Walt, E., ... Dippenaar, H. (2009). Nutritional, immune, micronutrient and health status of HIV-infected children in care centres in Manguang. <i>South African Journal of Clinical Nutrition</i>, http://hdl.handle.net/11427/24429en_ZA
dc.identifier.chicagocitationSteenkamp, L, A Dannhauser, D Walsh, G Joubert, F J Veldman, E Van der Walt, C Cox, M K Hendricks, and H Dippenaar "Nutritional, immune, micronutrient and health status of HIV-infected children in care centres in Manguang." <i>South African Journal of Clinical Nutrition</i> (2009) http://hdl.handle.net/11427/24429en_ZA
dc.identifier.citationSteenkamp, L., Dannhauser, A., Walsh, D., Joubert, G., Veldman, F. J., Van der Walt, E., Cox, C., Hendricks, M.K., & Dippenaar, H. (2009). Nutritional, immune, micronutrient and health status of HIV-infected children in care centres in Mangaung.South African Journal of Clinical Nutrition, 22(3).
dc.identifier.ris TY - Journal Article AU - Steenkamp, L AU - Dannhauser, A AU - Walsh, D AU - Joubert, G AU - Veldman, F J AU - Van der Walt, E AU - Cox, C AU - Hendricks, M K AU - Dippenaar, H AB - Aim: To assess the nutritional, immune, micronutrient and health status of antiretroviral-naïve HIV-infected children. Method: A cross-sectional descriptive study was undertaken between September 2004 and March 2006 amongst HIV-infected children of which none received antiretroviral therapy, in care centres in Mangaung, Free State. Results: The study included 37 clinically stable and food-secure HIV-infected children. Their median age was 5.4 years (range 1.2–10.2 years). Fifteen children (41%) were underweight, 30 (81%) were stunted and one (3%) was wasted. The most commonly observed clinical features were lymphadenopathy (84%), skin rashes (51%), hepatomegaly (32%) and pallor (41%). Eight per cent of children had features of TB, while 19% had a lower respiratory tract infection. The median viral load of the group (n = 35) was 117 000 copies/ml, the median CD4+ cell count was 477 cells/mm3 and the median CD4 percentage was 22.5%. A significant negative correlation could be demonstrated between viral load and nutritional indicators. Children had deficient serum levels relative to normal reference values for glutathione (91% of children), albumin (78%), vitamin A (63%), vitamin D (44%), zinc (38%) and vitamin E (13%). Sixty per cent of the children were anaemic and 30% were iron deficient. Conclusion: A high prevalence of acute and chronic malnutrition and micronutrient deficiencies occurred among HIV-infected children residing in care centres. The study highlights the need to investigate early initiation of antiretroviral therapy and nutrition interventions, including aggressive supplementation, in order to improve the prognosis of these children. DA - 2009 DB - OpenUCT DP - University of Cape Town J1 - South African Journal of Clinical Nutrition LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Nutritional, immune, micronutrient and health status of HIV-infected children in care centres in Manguang TI - Nutritional, immune, micronutrient and health status of HIV-infected children in care centres in Manguang UR - http://hdl.handle.net/11427/24429 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/24429
dc.identifier.vancouvercitationSteenkamp L, Dannhauser A, Walsh D, Joubert G, Veldman FJ, Van der Walt E, et al. Nutritional, immune, micronutrient and health status of HIV-infected children in care centres in Manguang. South African Journal of Clinical Nutrition. 2009; http://hdl.handle.net/11427/24429.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Child and Adolescent Psychiatryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceSouth African Journal of Clinical Nutrition
dc.source.urihttp://www.ajol.info/index.php/sajcn/about
dc.subject.otherHIV
dc.subject.othernutrition
dc.subject.otherimmune
dc.subject.otherhealth
dc.subject.otherAIDS orphans
dc.titleNutritional, immune, micronutrient and health status of HIV-infected children in care centres in Manguang
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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