The association of the AVPR2 gene with serum sodium and water imbalances during an Ironman Triathlon

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dc.contributor.advisorCollins, Malcolmen_ZA
dc.contributor.authorAh Kun, Maresaen_ZA
dc.date.accessioned2014-07-28T08:24:03Z
dc.date.available2014-07-28T08:24:03Z
dc.date.issued2007en_ZA
dc.descriptionIncludes bibliographical references (p. 120-138).
dc.description.abstractIt is well documented that participation in ultra-endurance events such as the Ironman Triathlon, can be associated with the development of post-race water and sodium imbalances in athletes. Variants within genes that encode for proteins that regulate thirst have been shown to be associated with weight changes during participation in an Ironman Triathlon. Recent evidence of mutations within the arginine vasopressin 2 receptor (AVPR2) gene, which encodes a constitutively active receptor in the collecting tubules of the kidney, resulted in increased water reabsorption and hyponatraemia in two unrelated male infants. This suggests that serum imbalances and hydration status in individuals participating in an endurance event may also be, in part, controlled by variants withink the AVPR2 gene. The aim of this study was to investigate whether polymorphisms within the AVPR2 gene are associated with exercise-associated serum sodium and/or water imbalances in triathletes who particpated in the 2006 South African Ironman Triathlon.en_ZA
dc.identifier.apacitationAh Kun, M. (2007). <i>The association of the AVPR2 gene with serum sodium and water imbalances during an Ironman Triathlon</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,MRC/UCT RU for Exercise and Sport Medicine. Retrieved from http://hdl.handle.net/11427/2774en_ZA
dc.identifier.chicagocitationAh Kun, Maresa. <i>"The association of the AVPR2 gene with serum sodium and water imbalances during an Ironman Triathlon."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,MRC/UCT RU for Exercise and Sport Medicine, 2007. http://hdl.handle.net/11427/2774en_ZA
dc.identifier.citationAh Kun, M. 2007. The association of the AVPR2 gene with serum sodium and water imbalances during an Ironman Triathlon. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Ah Kun, Maresa AB - It is well documented that participation in ultra-endurance events such as the Ironman Triathlon, can be associated with the development of post-race water and sodium imbalances in athletes. Variants within genes that encode for proteins that regulate thirst have been shown to be associated with weight changes during participation in an Ironman Triathlon. Recent evidence of mutations within the arginine vasopressin 2 receptor (AVPR2) gene, which encodes a constitutively active receptor in the collecting tubules of the kidney, resulted in increased water reabsorption and hyponatraemia in two unrelated male infants. This suggests that serum imbalances and hydration status in individuals participating in an endurance event may also be, in part, controlled by variants withink the AVPR2 gene. The aim of this study was to investigate whether polymorphisms within the AVPR2 gene are associated with exercise-associated serum sodium and/or water imbalances in triathletes who particpated in the 2006 South African Ironman Triathlon. DA - 2007 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2007 T1 - The association of the AVPR2 gene with serum sodium and water imbalances during an Ironman Triathlon TI - The association of the AVPR2 gene with serum sodium and water imbalances during an Ironman Triathlon UR - http://hdl.handle.net/11427/2774 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/2774
dc.identifier.vancouvercitationAh Kun M. The association of the AVPR2 gene with serum sodium and water imbalances during an Ironman Triathlon. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,MRC/UCT RU for Exercise and Sport Medicine, 2007 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/2774en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentMRC/UCT RU for Exercise and Sport Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherSports Medicineen_ZA
dc.titleThe association of the AVPR2 gene with serum sodium and water imbalances during an Ironman Triathlonen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMPhilen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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