Tumor-induced osteomalacia: a case report

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dc.contributor.authorAligail, Khalid
dc.contributor.authorDave, Joel A
dc.contributor.authorRoss, Ian L
dc.date.accessioned2022-04-06T09:01:28Z
dc.date.available2022-04-06T09:01:28Z
dc.date.issued2022-01-12
dc.date.updated2022-01-16T05:06:13Z
dc.description.abstractBackground Tumor-induced osteomalacia is a rare, acquired paraneoplastic syndrome, including hypophosphatemia, high serum alkaline phosphatase, reduced active vitamin D, suboptimal bone mineral density, bone pain, fragility fractures, and muscle weakness. Case presentation We report a case of 74–year–old male of mixed ancestry with hypophosphatemia resistant to treatment despite optimal compliance, associated with profound reduction of bone mineral density and multiple nontraumatic fractures, including bilateral rib fractures, lower-thoracic (T11, T12) vertebrae, and two fractures involving the surgical and anatomical neck of the right humerus. We discuss an approach to identifying the underlying cause of hypophosphatemia associated with fragility fractures, and options for management of this rare condition. Conclusion Although rare, tumor-induced osteomalacia can be diagnosed if a logical stepwise approach is implemented. Surgery could be curative if the tumor is properly located and is resectable.en_US
dc.identifier.apacitationAligail, K., Dave, J. A., & Ross, I. L. (2022). Tumor-induced osteomalacia: a case report. <i>Journal of Medical Case Reports</i>, 16(1), 22. http://hdl.handle.net/11427/36282en_ZA
dc.identifier.chicagocitationAligail, Khalid, Joel A Dave, and Ian L Ross "Tumor-induced osteomalacia: a case report." <i>Journal of Medical Case Reports</i> 16, 1. (2022): 22. http://hdl.handle.net/11427/36282en_ZA
dc.identifier.citationAligail, K., Dave, J.A. & Ross, I.L. 2022. Tumor-induced osteomalacia: a case report. <i>Journal of Medical Case Reports.</i> 16(1):22. http://hdl.handle.net/11427/36282en_ZA
dc.identifier.ris TY - Journal Article AU - Aligail, Khalid AU - Dave, Joel A AU - Ross, Ian L AB - Background Tumor-induced osteomalacia is a rare, acquired paraneoplastic syndrome, including hypophosphatemia, high serum alkaline phosphatase, reduced active vitamin D, suboptimal bone mineral density, bone pain, fragility fractures, and muscle weakness. Case presentation We report a case of 74–year–old male of mixed ancestry with hypophosphatemia resistant to treatment despite optimal compliance, associated with profound reduction of bone mineral density and multiple nontraumatic fractures, including bilateral rib fractures, lower-thoracic (T11, T12) vertebrae, and two fractures involving the surgical and anatomical neck of the right humerus. We discuss an approach to identifying the underlying cause of hypophosphatemia associated with fragility fractures, and options for management of this rare condition. Conclusion Although rare, tumor-induced osteomalacia can be diagnosed if a logical stepwise approach is implemented. Surgery could be curative if the tumor is properly located and is resectable. DA - 2022-01-12 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Journal of Medical Case Reports KW - Tumor-induced osteomalacia KW - Osteomalacia KW - Hypophosphatemia KW - Fibroblast growth factor-23 LK - https://open.uct.ac.za PY - 2022 T1 - Tumor-induced osteomalacia: a case report TI - Tumor-induced osteomalacia: a case report UR - http://hdl.handle.net/11427/36282 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s13256-021-03220-7
dc.identifier.urihttp://hdl.handle.net/11427/36282
dc.identifier.vancouvercitationAligail K, Dave JA, Ross IL. Tumor-induced osteomalacia: a case report. Journal of Medical Case Reports. 2022;16(1):22. http://hdl.handle.net/11427/36282.en_ZA
dc.language.rfc3066en
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceJournal of Medical Case Reportsen_US
dc.source.journalissue1en_US
dc.source.journalvolume16en_US
dc.source.pagination22en_US
dc.source.urihttps://jmedicalcasereports.biomedcentral.com/
dc.subjectTumor-induced osteomalaciaen_US
dc.subjectOsteomalaciaen_US
dc.subjectHypophosphatemiaen_US
dc.subjectFibroblast growth factor-23en_US
dc.titleTumor-induced osteomalacia: a case reporten_US
dc.typeJournal Articleen_US
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