Ventriculoperitoneal shunt insertion for hydrocephalus in human immunodeficiency virus-infected adults: a systematic review and meta-analysis protocol

dc.contributor.authorLoan, James J M
dc.contributor.authorMankahla, Ncedile
dc.contributor.authorMeintjes, Graeme
dc.contributor.authorFieggen, A Graham
dc.date.accessioned2017-10-25T11:27:27Z
dc.date.available2017-10-25T11:27:27Z
dc.date.issued2017-10-16
dc.date.updated2017-10-23T16:04:11Z
dc.description.abstractBackground: Hydrocephalus is a recognised complication of human immunodeficiency virus (HIV)-related opportunistic infections. Symptomatic raised cerebrospinal fluid pressure can be treated with ventriculoperitoneal shunt insertion (VPS). In HIV-infected patients however, there is a concern that VPS might be associated with unacceptably high rates of mortality. We aim to systematically review and appraise published literature to determine reported outcomes and identify predictors of outcome following VPS in relevant subgroups of HIV-infected adults. Methods: The following electronic databases will be searched: The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (PubMed), EMBASE, CINAHL (EBSCOhost), LILACS (BIREME), Research Registry (www.researchregistry.com), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov) and OpenSIGLE database. Any randomised studies, cohort studies, case-control studies, interrupted time series or sequential case series reporting survival following VPS in HIV-infected individuals will be included. If high-quality homogenous studies exist, meta-analysis will be conducted to determine 1-, 6- and 12-month mortality with comparison made between underlying aetiologies of hydrocephalus. Discussion and conclusion: This study will generate a comprehensive review of VPS in HIV-infected patients for publication. The primary outcome of meta-analysis is 12-month survival. If only low-quality, heterogeneous studies are available, this study will demonstrate this deficiency and will be of value in justifying and aiding the design of future studies. Systematic review registration: PROSPERO CRD42016052239
dc.identifier.apacitationLoan, J. J. M., Mankahla, N., Meintjes, G., & Fieggen, A. G. (2017). Ventriculoperitoneal shunt insertion for hydrocephalus in human immunodeficiency virus-infected adults: a systematic review and meta-analysis protocol. <i>Systematic Reviews</i>, http://hdl.handle.net/11427/25813en_ZA
dc.identifier.chicagocitationLoan, James J M, Ncedile Mankahla, Graeme Meintjes, and A Graham Fieggen "Ventriculoperitoneal shunt insertion for hydrocephalus in human immunodeficiency virus-infected adults: a systematic review and meta-analysis protocol." <i>Systematic Reviews</i> (2017) http://hdl.handle.net/11427/25813en_ZA
dc.identifier.citationLoan, J. J., Mankahla, N., Meintjes, G., & Fieggen, A. G. (2017). Ventriculoperitoneal shunt insertion for hydrocephalus in human immunodeficiency virus-infected adults: a systematic review and meta-analysis protocol. Systematic Reviews, 6(1), 201.
dc.identifier.ris TY - Journal Article AU - Loan, James J M AU - Mankahla, Ncedile AU - Meintjes, Graeme AU - Fieggen, A Graham AB - Background: Hydrocephalus is a recognised complication of human immunodeficiency virus (HIV)-related opportunistic infections. Symptomatic raised cerebrospinal fluid pressure can be treated with ventriculoperitoneal shunt insertion (VPS). In HIV-infected patients however, there is a concern that VPS might be associated with unacceptably high rates of mortality. We aim to systematically review and appraise published literature to determine reported outcomes and identify predictors of outcome following VPS in relevant subgroups of HIV-infected adults. Methods: The following electronic databases will be searched: The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (PubMed), EMBASE, CINAHL (EBSCOhost), LILACS (BIREME), Research Registry (www.researchregistry.com), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov) and OpenSIGLE database. Any randomised studies, cohort studies, case-control studies, interrupted time series or sequential case series reporting survival following VPS in HIV-infected individuals will be included. If high-quality homogenous studies exist, meta-analysis will be conducted to determine 1-, 6- and 12-month mortality with comparison made between underlying aetiologies of hydrocephalus. Discussion and conclusion: This study will generate a comprehensive review of VPS in HIV-infected patients for publication. The primary outcome of meta-analysis is 12-month survival. If only low-quality, heterogeneous studies are available, this study will demonstrate this deficiency and will be of value in justifying and aiding the design of future studies. Systematic review registration: PROSPERO CRD42016052239 DA - 2017-10-16 DB - OpenUCT DO - 10.1186/s13643-017-0603-7 DP - University of Cape Town J1 - Systematic Reviews LK - https://open.uct.ac.za PB - University of Cape Town PY - 2017 T1 - Ventriculoperitoneal shunt insertion for hydrocephalus in human immunodeficiency virus-infected adults: a systematic review and meta-analysis protocol TI - Ventriculoperitoneal shunt insertion for hydrocephalus in human immunodeficiency virus-infected adults: a systematic review and meta-analysis protocol UR - http://hdl.handle.net/11427/25813 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1186/s13643-017-0603-7
dc.identifier.urihttp://hdl.handle.net/11427/25813
dc.identifier.vancouvercitationLoan JJM, Mankahla N, Meintjes G, Fieggen AG. Ventriculoperitoneal shunt insertion for hydrocephalus in human immunodeficiency virus-infected adults: a systematic review and meta-analysis protocol. Systematic Reviews. 2017; http://hdl.handle.net/11427/25813.en_ZA
dc.language.isoen
dc.publisherBioMed Central
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rights.holderThe Author(s).
dc.sourceSystematic Reviews
dc.source.urihttps://systematicreviewsjournal.biomedcentral.com/
dc.titleVentriculoperitoneal shunt insertion for hydrocephalus in human immunodeficiency virus-infected adults: a systematic review and meta-analysis protocol
dc.typeJournal Article
uct.type.filetypeText
uct.type.filetypeImage
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