Cerebral Arterial Asymmetries in the Neonate: Insight into the Pathogenesis of Stroke
| dc.contributor.author | van Vuuren, Anica Jansen | |
| dc.contributor.author | Saling, Michael | |
| dc.contributor.author | Rogerson, Sheryle | |
| dc.contributor.author | Anderson, Peter | |
| dc.contributor.author | Cheong, Jeanie | |
| dc.contributor.author | Solms, Mark | |
| dc.date.accessioned | 2022-04-13T09:24:48Z | |
| dc.date.available | 2022-04-13T09:24:48Z | |
| dc.date.issued | 2022-02-24 | |
| dc.date.updated | 2022-03-24T14:47:12Z | |
| dc.description.abstract | Neonatal and adult strokes are more common in the left than in the right cerebral hemisphere in the middle cerebral arterial territory, and adult extracranial and intracranial vessels are systematically left-dominant. The aim of the research reported here was to determine whether the asymmetric vascular ground plan found in adults was present in healthy term neonates (n = 97). A new transcranial Doppler ultrasonography dual-view scanning protocol, with concurrent B-flow and pulsed wave imaging, acquired multivariate data on the neonatal middle cerebral arterial structure and function. This study documents for the first-time systematic asymmetries in the middle cerebral artery origin and distal trunk of healthy term neonates and identifies commensurately asymmetric hemodynamic vulnerabilities. A systematic leftward arterial dominance was found in the arterial caliber and cortically directed blood flow. The endothelial wall shear stress was also asymmetric across the midline and varied according to vessels’ geometry. We conclude that the arterial structure and blood supply in the brain are laterally asymmetric in newborns. Unfavorable shearing forces, which are a by-product of the arterial asymmetries described here, might contribute to a greater risk of cerebrovascular pathology in the left hemisphere. | |
| dc.identifier | doi: 10.3390/sym14030456 | |
| dc.identifier.apacitation | van Vuuren, A. J., Saling, M., Rogerson, S., Anderson, P., Cheong, J., & Solms, M. (2022). Cerebral Arterial Asymmetries in the Neonate: Insight into the Pathogenesis of Stroke. <i>Symmetry</i>, 14(3), http://hdl.handle.net/11427/36363 | en_ZA |
| dc.identifier.chicagocitation | van Vuuren, Anica Jansen, Michael Saling, Sheryle Rogerson, Peter Anderson, Jeanie Cheong, and Mark Solms "Cerebral Arterial Asymmetries in the Neonate: Insight into the Pathogenesis of Stroke." <i>Symmetry</i> 14, 3. (2022) http://hdl.handle.net/11427/36363 | en_ZA |
| dc.identifier.citation | van Vuuren, A.J., Saling, M., Rogerson, S., Anderson, P., Cheong, J. & Solms, M. 2022. Cerebral Arterial Asymmetries in the Neonate: Insight into the Pathogenesis of Stroke. <i>Symmetry.</i> 14(3) http://hdl.handle.net/11427/36363 | en_ZA |
| dc.identifier.ris | TY - Journal Article AU - van Vuuren, Anica Jansen AU - Saling, Michael AU - Rogerson, Sheryle AU - Anderson, Peter AU - Cheong, Jeanie AU - Solms, Mark AB - Neonatal and adult strokes are more common in the left than in the right cerebral hemisphere in the middle cerebral arterial territory, and adult extracranial and intracranial vessels are systematically left-dominant. The aim of the research reported here was to determine whether the asymmetric vascular ground plan found in adults was present in healthy term neonates (n = 97). A new transcranial Doppler ultrasonography dual-view scanning protocol, with concurrent B-flow and pulsed wave imaging, acquired multivariate data on the neonatal middle cerebral arterial structure and function. This study documents for the first-time systematic asymmetries in the middle cerebral artery origin and distal trunk of healthy term neonates and identifies commensurately asymmetric hemodynamic vulnerabilities. A systematic leftward arterial dominance was found in the arterial caliber and cortically directed blood flow. The endothelial wall shear stress was also asymmetric across the midline and varied according to vessels’ geometry. We conclude that the arterial structure and blood supply in the brain are laterally asymmetric in newborns. Unfavorable shearing forces, which are a by-product of the arterial asymmetries described here, might contribute to a greater risk of cerebrovascular pathology in the left hemisphere. DA - 2022-02-24 DB - OpenUCT DP - University of Cape Town IS - 3 J1 - Symmetry KW - middle cerebral artery KW - diameter KW - blood flow KW - asymmetry KW - stroke KW - shear stress KW - neonate LK - https://open.uct.ac.za PY - 2022 T1 - Cerebral Arterial Asymmetries in the Neonate: Insight into the Pathogenesis of Stroke TI - Cerebral Arterial Asymmetries in the Neonate: Insight into the Pathogenesis of Stroke UR - http://hdl.handle.net/11427/36363 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/36363 | |
| dc.identifier.uri | https://doi.org/10.3390/sym14030456 | |
| dc.identifier.vancouvercitation | van Vuuren AJ, Saling M, Rogerson S, Anderson P, Cheong J, Solms M. Cerebral Arterial Asymmetries in the Neonate: Insight into the Pathogenesis of Stroke. Symmetry. 2022;14(3) http://hdl.handle.net/11427/36363. | en_ZA |
| dc.publisher | Multidisciplinary Digital Publishing Institute | |
| dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.source | Symmetry | |
| dc.source.journalissue | 3 | |
| dc.source.journalvolume | 14 | |
| dc.source.uri | https://www.mdpi.com/journal/symmetry | |
| dc.subject | middle cerebral artery | |
| dc.subject | diameter | |
| dc.subject | blood flow | |
| dc.subject | asymmetry | |
| dc.subject | stroke | |
| dc.subject | shear stress | |
| dc.subject | neonate | |
| dc.title | Cerebral Arterial Asymmetries in the Neonate: Insight into the Pathogenesis of Stroke | |
| dc.type | Journal Article |