Outcomes of penetrating keratoplasty at a tertiary institution in South Africa.
| dc.contributor.advisor | du Toit, Nagib | |
| dc.contributor.author | Theron, Yolande | |
| dc.date.accessioned | 2024-06-06T09:50:48Z | |
| dc.date.available | 2024-06-06T09:50:48Z | |
| dc.date.issued | 2023 | |
| dc.date.updated | 2024-06-06T09:33:30Z | |
| dc.description.abstract | Aims: To determine corneal graft survival rates and visual outcomes of penetrating keratoplasty (PKP) in a South African setting. Methods: A retrospective review of 99 penetrating keratoplasties performed at Groote Schuur Hospital, South Africa over a 3-year period between February 2016 and February 2019. Results: The mean age of study participants was 38 years (14-85). The study included 60% females and 40% males. The main indications for surgery were keratoconus (58%), corneal scar (21%), regrafts (8%), pseudophakic bullous keratopathy (6%), corneal dystrophies (3%) and pellucid marginal degeneration (1%). The overall graft survival at 1-year follow up was 86%. A higher 1-year graft survival rate of 94% was seen in patients with keratoconus. The total number of patients diagnosed with graft failure at 1 year was 13.The Kaplan-Meier survival analysis was used to assess time to graft failure. The estimate was 11.7 months (mean time to graft failure) with a 95% CI confidence interval from 11.4 to 12 months. In our study, best corrected Snellen acuity in the category of 6/6-6/18 was found in 59.2% of patients 1-one year post-operatively, compared with 1% of patients in the same BCVA group pre-operatively. Patients with a BCVA equal to 3/60 or less reduced from 56% preoperatively to 20% postoperatively at 1 one year. Conclusion: Penetrating Keratoplasty is an effective long term treatment option to restore visual acuity in certain corneal disorders in a middle to low-income country. Our results demonstrated a comparable 1-year graft survival rate to high-income countries. | |
| dc.identifier.apacitation | Theron, Y. (2023). <i>Outcomes of penetrating keratoplasty at a tertiary institution in South Africa</i>. (). ,Faculty of Health Sciences ,Division of General Surgery. Retrieved from http://hdl.handle.net/11427/39884 | en_ZA |
| dc.identifier.chicagocitation | Theron, Yolande. <i>"Outcomes of penetrating keratoplasty at a tertiary institution in South Africa."</i> ., ,Faculty of Health Sciences ,Division of General Surgery, 2023. http://hdl.handle.net/11427/39884 | en_ZA |
| dc.identifier.citation | Theron, Y. 2023. Outcomes of penetrating keratoplasty at a tertiary institution in South Africa. . ,Faculty of Health Sciences ,Division of General Surgery. http://hdl.handle.net/11427/39884 | en_ZA |
| dc.identifier.ris | TY - Thesis / Dissertation AU - Theron, Yolande AB - Aims: To determine corneal graft survival rates and visual outcomes of penetrating keratoplasty (PKP) in a South African setting. Methods: A retrospective review of 99 penetrating keratoplasties performed at Groote Schuur Hospital, South Africa over a 3-year period between February 2016 and February 2019. Results: The mean age of study participants was 38 years (14-85). The study included 60% females and 40% males. The main indications for surgery were keratoconus (58%), corneal scar (21%), regrafts (8%), pseudophakic bullous keratopathy (6%), corneal dystrophies (3%) and pellucid marginal degeneration (1%). The overall graft survival at 1-year follow up was 86%. A higher 1-year graft survival rate of 94% was seen in patients with keratoconus. The total number of patients diagnosed with graft failure at 1 year was 13.The Kaplan-Meier survival analysis was used to assess time to graft failure. The estimate was 11.7 months (mean time to graft failure) with a 95% CI confidence interval from 11.4 to 12 months. In our study, best corrected Snellen acuity in the category of 6/6-6/18 was found in 59.2% of patients 1-one year post-operatively, compared with 1% of patients in the same BCVA group pre-operatively. Patients with a BCVA equal to 3/60 or less reduced from 56% preoperatively to 20% postoperatively at 1 one year. Conclusion: Penetrating Keratoplasty is an effective long term treatment option to restore visual acuity in certain corneal disorders in a middle to low-income country. Our results demonstrated a comparable 1-year graft survival rate to high-income countries. DA - 2023 DB - OpenUCT DP - University of Cape Town KW - General Surgery LK - https://open.uct.ac.za PY - 2023 T1 - Outcomes of penetrating keratoplasty at a tertiary institution in South Africa TI - Outcomes of penetrating keratoplasty at a tertiary institution in South Africa UR - http://hdl.handle.net/11427/39884 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/39884 | |
| dc.identifier.vancouvercitation | Theron Y. Outcomes of penetrating keratoplasty at a tertiary institution in South Africa. []. ,Faculty of Health Sciences ,Division of General Surgery, 2023 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/39884 | en_ZA |
| dc.language.rfc3066 | eng | |
| dc.publisher.department | Division of General Surgery | |
| dc.publisher.faculty | Faculty of Health Sciences | |
| dc.subject | General Surgery | |
| dc.title | Outcomes of penetrating keratoplasty at a tertiary institution in South Africa. | |
| dc.type | Thesis / Dissertation | |
| dc.type.qualificationlevel | Masters | |
| dc.type.qualificationlevel | MMed |