Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa

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dc.contributor.authorKastien-Hilka, Tanja
dc.contributor.authorAbulfathi, Ahmed
dc.contributor.authorRosenkranz, Bernd
dc.contributor.authorBennett, Bryan
dc.contributor.authorSchwenkglenks, Matthias
dc.contributor.authorSinanovic, Edina
dc.date.accessioned2021-10-08T07:04:11Z
dc.date.available2021-10-08T07:04:11Z
dc.date.issued2016
dc.description.abstractIntroductionTuberculosis (TB) is a leading cause of morbidity and mortality in South Africa. Clinical parameters are important objective outcomes in TB; however they often are not directly correlated with subjective well-being of the patient, but can be assessed using patient-reported outcome (PRO) measures. Health-related quality of life (HRQOL) is a specific PRO generally multi-dimensional in nature and includes physical, mental and social health domains. The inclusion of HRQOL PROs in trials and clinical practice can provide additional information beyondclinical and microbiological parameters. Furthermore, HRQOL may be associated with medication adherence. This review focuses on patient-reported HRQOL and its association with medication adherence in TB patients in South Africa.MethodsA comprehensive search strategy was developed focusing on the impact of TB on patient-reported HRQOL,the existence of a conceptual framework of TB-specific HRQOL, determinants of medication adherence and the association of HRQOL with medication adherence. Data were extracted from all identified articles and additionaldata extraction was performed by two independent reviewers with special focus on longitudinal studies in order to understand changes of HRQOL and adherence over time. Research gaps were identified with regard to patient-reported HRQOL and medication adherence.ResultsA total of 66 articles met the eligibility criteria. Ten HRQOL studies and one adherence study used a longitudinal design, none of these in South Africa. A variety of different generic and disease-specific HRQOL measures were identified in the articles. In South Africa four HRQOL and five adherence studies (non-longitudinal) were published. Similar factors (socio-demographic, socio-economic, disease-related, therapy-related and psycho-social aspects) affect HRQOL and adherence. Although standard TB treatment improved all health domains, psychological well-being and social functioning remained impaired in microbiologically cured patients after treatment.ConclusionWhile evidence of TB impact on HRQOL and medication adherence and their association exists, it is verylimited for the South African situation. No valid and reliable TB-specific HRQOL measures were identified in this systematicreview. An assessment of HRQOL in TB patients in South Africa is required as this may assist with improving current disease management programmes, medication adherence and national treatment guidelines.Electronic supplementary materialThe online version of this article (doi:10.1186/s12955-016-0442-6) contains supplementary material, which is available to authorized users.
dc.identifier.apacitationKastien-Hilka, T., Abulfathi, A., Rosenkranz, B., Bennett, B., Schwenkglenks, M., & Sinanovic, E. (2016). Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa. <i>Health and Quality of Life Outcomes</i>, 14(1), 174 - 177. http://hdl.handle.net/11427/34448en_ZA
dc.identifier.chicagocitationKastien-Hilka, Tanja, Ahmed Abulfathi, Bernd Rosenkranz, Bryan Bennett, Matthias Schwenkglenks, and Edina Sinanovic "Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa." <i>Health and Quality of Life Outcomes</i> 14, 1. (2016): 174 - 177. http://hdl.handle.net/11427/34448en_ZA
dc.identifier.citationKastien-Hilka, T., Abulfathi, A., Rosenkranz, B., Bennett, B., Schwenkglenks, M. & Sinanovic, E. 2016. Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa. <i>Health and Quality of Life Outcomes.</i> 14(1):174 - 177. http://hdl.handle.net/11427/34448en_ZA
dc.identifier.issn1477-7525
dc.identifier.ris TY - Journal Article AU - Kastien-Hilka, Tanja AU - Abulfathi, Ahmed AU - Rosenkranz, Bernd AU - Bennett, Bryan AU - Schwenkglenks, Matthias AU - Sinanovic, Edina AB - IntroductionTuberculosis (TB) is a leading cause of morbidity and mortality in South Africa. Clinical parameters are important objective outcomes in TB; however they often are not directly correlated with subjective well-being of the patient, but can be assessed using patient-reported outcome (PRO) measures. Health-related quality of life (HRQOL) is a specific PRO generally multi-dimensional in nature and includes physical, mental and social health domains. The inclusion of HRQOL PROs in trials and clinical practice can provide additional information beyondclinical and microbiological parameters. Furthermore, HRQOL may be associated with medication adherence. This review focuses on patient-reported HRQOL and its association with medication adherence in TB patients in South Africa.MethodsA comprehensive search strategy was developed focusing on the impact of TB on patient-reported HRQOL,the existence of a conceptual framework of TB-specific HRQOL, determinants of medication adherence and the association of HRQOL with medication adherence. Data were extracted from all identified articles and additionaldata extraction was performed by two independent reviewers with special focus on longitudinal studies in order to understand changes of HRQOL and adherence over time. Research gaps were identified with regard to patient-reported HRQOL and medication adherence.ResultsA total of 66 articles met the eligibility criteria. Ten HRQOL studies and one adherence study used a longitudinal design, none of these in South Africa. A variety of different generic and disease-specific HRQOL measures were identified in the articles. In South Africa four HRQOL and five adherence studies (non-longitudinal) were published. Similar factors (socio-demographic, socio-economic, disease-related, therapy-related and psycho-social aspects) affect HRQOL and adherence. Although standard TB treatment improved all health domains, psychological well-being and social functioning remained impaired in microbiologically cured patients after treatment.ConclusionWhile evidence of TB impact on HRQOL and medication adherence and their association exists, it is verylimited for the South African situation. No valid and reliable TB-specific HRQOL measures were identified in this systematicreview. An assessment of HRQOL in TB patients in South Africa is required as this may assist with improving current disease management programmes, medication adherence and national treatment guidelines.Electronic supplementary materialThe online version of this article (doi:10.1186/s12955-016-0442-6) contains supplementary material, which is available to authorized users. DA - 2016 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Health and Quality of Life Outcomes LK - https://open.uct.ac.za PY - 2016 SM - 1477-7525 T1 - Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa TI - Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa UR - http://hdl.handle.net/11427/34448 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34448
dc.identifier.vancouvercitationKastien-Hilka T, Abulfathi A, Rosenkranz B, Bennett B, Schwenkglenks M, Sinanovic E. Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa. Health and Quality of Life Outcomes. 2016;14(1):174 - 177. http://hdl.handle.net/11427/34448.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Public Health and Family Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceHealth and Quality of Life Outcomes
dc.source.journalissue1
dc.source.journalvolume14
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1186/s12955-016-0442-6
dc.subject.otherHealth-related quality of life
dc.subject.otherMedication adherence
dc.subject.otherPatient-reported outcomes
dc.subject.otherSouth Africa
dc.subject.otherTuberculosis
dc.subject.otherAdult
dc.subject.otherAfrican Continental Ancestry Group
dc.subject.otherAged
dc.subject.otherAged, 80 and over
dc.subject.otherAttitude to Health
dc.subject.otherFemale
dc.subject.otherHumans
dc.subject.otherMale
dc.subject.otherMedication Adherence
dc.subject.otherMiddle Aged
dc.subject.otherQuality of Life
dc.subject.otherSouth Africa
dc.subject.otherTuberculosis, Pulmonary
dc.titleHealth-related quality of life and its association with medication adherence in active pulmonary tuberculosis– a systematic review of global literature with focus on South Africa
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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