New Insights into the Diversity of Branchiomeric Muscle Development: Genetic Programs and Differentiation
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2022-08-22
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Biology
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Multidisciplinary Digital Publishing Institute
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Abstract
Branchiomeric skeletal muscles are a subset of head muscles originating from skeletal muscle progenitor cells in the mesodermal core of pharyngeal arches. These muscles are involved in facial expression, mastication, and function of the larynx and pharynx. Branchiomeric muscles have been the focus of many studies over the years due to their distinct developmental programs and common origin with the heart muscle. A prerequisite for investigating these muscles’ properties and therapeutic potential is understanding their genetic program and differentiation. In contrast to our understanding of how branchiomeric muscles are formed, less is known about their differentiation. This review focuses on the differentiation of branchiomeric muscles in mouse embryos. Furthermore, the relationship between branchiomeric muscle progenitor and neural crest cells in the pharyngeal arches of chicken embryos is also discussed. Additionally, we summarize recent studies into the genetic networks that distinguish between first arch-derived muscles and other pharyngeal arch muscles.
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Yahya, I., Hockman, D., Brand-Saberi, B. & Morosan-Puopolo, G. 2022. New Insights into the Diversity of Branchiomeric Muscle Development: Genetic Programs and Differentiation. Biology. 11(8):1245. http://hdl.handle.net/11427/38716