Treatment as prevention: preparing the way

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dc.contributor.authorWilliams, Brianen_ZA
dc.contributor.authorWood, Robinen_ZA
dc.contributor.authorDukay, Victoren_ZA
dc.contributor.authorDelva, Wimen_ZA
dc.contributor.authorGinsburg, Daviden_ZA
dc.contributor.authorHargrove, Johnen_ZA
dc.contributor.authorStander, Martinusen_ZA
dc.contributor.authorSheneberger, Roberten_ZA
dc.contributor.authorMontaner, Julioen_ZA
dc.contributor.authorWelte, Alexen_ZA
dc.date.accessioned2015-11-18T03:54:17Z
dc.date.available2015-11-18T03:54:17Z
dc.date.issued2011en_ZA
dc.description.abstractPotent antiretroviral therapy (ART) reduces mortality and morbidity in people living with HIV by reducing viral load and allowing their immune systems to recover. The reduction in viral load soon after starting ART has led to the hypothesis that early and widespread ART could prevent onward transmission and therefore eliminate the HIV epidemic in the long term. While several authors have argued that it is feasible to use HIV treatment as prevention (TasP), provided treatment is started sufficiently early, others have reasonably drawn attention to the many operational difficulties that will need to be overcome if the strategy is to succeed in reducing HIV transmission. Furthermore, international public health policy must be based on more than theoretical studies, no matter how appealing. Community randomized controlled trials provide the gold standard for testing the extent to which early treatment reduces incidence, but much still needs to be understood and the immediate need is for operational studies to explore the practical feasibility of this approach. Here, we examine some of the issues to be addressed, the obstacles to be overcome, and strategies that may be necessary if TasP is to be effective. Studies of this kind will provide valuable information for the design of large-scale trials, as well as essential information that will be needed if early treatment is to be incorporated into public health policy.en_ZA
dc.identifier.apacitationWilliams, B., Wood, R., Dukay, V., Delva, W., Ginsburg, D., Hargrove, J., ... Welte, A. (2011). Treatment as prevention: preparing the way. <i>Journal of the International AIDS Society</i>, http://hdl.handle.net/11427/15060en_ZA
dc.identifier.chicagocitationWilliams, Brian, Robin Wood, Victor Dukay, Wim Delva, David Ginsburg, John Hargrove, Martinus Stander, Robert Sheneberger, Julio Montaner, and Alex Welte "Treatment as prevention: preparing the way." <i>Journal of the International AIDS Society</i> (2011) http://hdl.handle.net/11427/15060en_ZA
dc.identifier.citationWilliams, B., Wood, R., Dukay, V., Delva, W., Ginsburg, D., Hargrove, J., ... & Welte, A. (2011). Treatment as prevention: preparing the way. Journal of the International AIDS Society, 14(Suppl 1), S6.en_ZA
dc.identifier.ris TY - Journal Article AU - Williams, Brian AU - Wood, Robin AU - Dukay, Victor AU - Delva, Wim AU - Ginsburg, David AU - Hargrove, John AU - Stander, Martinus AU - Sheneberger, Robert AU - Montaner, Julio AU - Welte, Alex AB - Potent antiretroviral therapy (ART) reduces mortality and morbidity in people living with HIV by reducing viral load and allowing their immune systems to recover. The reduction in viral load soon after starting ART has led to the hypothesis that early and widespread ART could prevent onward transmission and therefore eliminate the HIV epidemic in the long term. While several authors have argued that it is feasible to use HIV treatment as prevention (TasP), provided treatment is started sufficiently early, others have reasonably drawn attention to the many operational difficulties that will need to be overcome if the strategy is to succeed in reducing HIV transmission. Furthermore, international public health policy must be based on more than theoretical studies, no matter how appealing. Community randomized controlled trials provide the gold standard for testing the extent to which early treatment reduces incidence, but much still needs to be understood and the immediate need is for operational studies to explore the practical feasibility of this approach. Here, we examine some of the issues to be addressed, the obstacles to be overcome, and strategies that may be necessary if TasP is to be effective. Studies of this kind will provide valuable information for the design of large-scale trials, as well as essential information that will be needed if early treatment is to be incorporated into public health policy. DA - 2011 DB - OpenUCT DO - 10.1186/1758-2652-14-S1-S6 DP - University of Cape Town J1 - Journal of the International AIDS Society LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Treatment as prevention: preparing the way TI - Treatment as prevention: preparing the way UR - http://hdl.handle.net/11427/15060 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15060
dc.identifier.urihttp://dx.doi.org/10.1186/1758-2652-14-S1-S6
dc.identifier.vancouvercitationWilliams B, Wood R, Dukay V, Delva W, Ginsburg D, Hargrove J, et al. Treatment as prevention: preparing the way. Journal of the International AIDS Society. 2011; http://hdl.handle.net/11427/15060.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDesmond Tutu HIV Centreen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2011 Williams et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceJournal of the International AIDS Societyen_ZA
dc.source.urihttp://archive.biomedcentral.com/1758-2652/en_ZA
dc.subject.otherPotent antiretroviral therapy (ART)en_ZA
dc.subject.otherPeople living with HIVen_ZA
dc.subject.otherHIV transmissionen_ZA
dc.titleTreatment as prevention: preparing the wayen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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