Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis

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dc.contributor.authorBarth, Dylan D
dc.contributor.authorDaw, Jessica
dc.contributor.authorXu, Ruomei
dc.contributor.authorEnkel, Stephanie
dc.contributor.authorPickering, Janessa
dc.contributor.authorMcRae, Tracy
dc.contributor.authorEngel, Mark E
dc.contributor.authorCarapetis, Jonathan
dc.contributor.authorWyber, Rosemary
dc.contributor.authorBowen, Asha C
dc.date.accessioned2021-10-11T16:37:24Z
dc.date.available2021-10-11T16:37:24Z
dc.date.issued2021-03-31
dc.date.updated2021-04-06T09:49:20Z
dc.description.abstractBackground Group A Streptococcus (Strep A) is an important cause of mortality and morbidity globally. This bacterium is responsible for a range of different infections and post-infectious sequelae. Summarising the current knowledge of Strep A transmission to humans will address gaps in the evidence and inform prevention and control strategies. The objective of this study is to evaluate the modes of transmission and attack rates of group A streptococcal infection in human populations. Methods This systematic review protocol was prepared according to the Preferred Reporting Items for Systematic reviews and Meta-analysis Protocols (PRISMA-P) 2015 Statement. Using a comprehensive search strategy to identify any transmission studies that have been published in English since 1980, full-text articles will be identified and considered for inclusion against predefined criteria. We will include all studies reporting on Strep A transmission, who have identified a mode of transmission, and who reported attack rates. Risk of bias will be appraised using an appropriate tool. Our results will be described narratively and where feasible and appropriate, a meta-analysis utilizing the random-effects model will be used to aggregate the incidence proportions (attack rates) for each mode of transmission. In addition, we will also evaluate the emm genotype variants of the M protein causing Strep A infection and the association with transmission routes and attack rates, if any, by setting, socioeconomic background and geographical regions. Discussion We anticipate that this review will contribute to elucidating Strep A modes of transmission which in turn, will serve to inform evidence-based strategies including environmental health activities to reduce the transmission of Strep A in populations at risk of severe disease. Trial registration Systematic review registration: PROSPERO ( CRD42019138472 ).en_US
dc.identifier.apacitationBarth, D. D., Daw, J., Xu, R., Enkel, S., Pickering, J., McRae, T., ... Bowen, A. C. (2021). Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis. <i>Systematic Reviews</i>, 10(Article number: 90), http://hdl.handle.net/11427/35162en_ZA
dc.identifier.chicagocitationBarth, Dylan D, Jessica Daw, Ruomei Xu, Stephanie Enkel, Janessa Pickering, Tracy McRae, Mark E Engel, Jonathan Carapetis, Rosemary Wyber, and Asha C Bowen "Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis." <i>Systematic Reviews</i> 10, Article number: 90. (2021) http://hdl.handle.net/11427/35162en_ZA
dc.identifier.citationBarth, D.D., Daw, J., Xu, R., Enkel, S., Pickering, J., McRae, T., Engel, M.E. & Carapetis, J. et al. 2021. Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis. <i>Systematic Reviews.</i> 10(Article number: 90) http://hdl.handle.net/11427/35162en_ZA
dc.identifier.ris TY - Journal Article AU - Barth, Dylan D AU - Daw, Jessica AU - Xu, Ruomei AU - Enkel, Stephanie AU - Pickering, Janessa AU - McRae, Tracy AU - Engel, Mark E AU - Carapetis, Jonathan AU - Wyber, Rosemary AU - Bowen, Asha C AB - Background Group A Streptococcus (Strep A) is an important cause of mortality and morbidity globally. This bacterium is responsible for a range of different infections and post-infectious sequelae. Summarising the current knowledge of Strep A transmission to humans will address gaps in the evidence and inform prevention and control strategies. The objective of this study is to evaluate the modes of transmission and attack rates of group A streptococcal infection in human populations. Methods This systematic review protocol was prepared according to the Preferred Reporting Items for Systematic reviews and Meta-analysis Protocols (PRISMA-P) 2015 Statement. Using a comprehensive search strategy to identify any transmission studies that have been published in English since 1980, full-text articles will be identified and considered for inclusion against predefined criteria. We will include all studies reporting on Strep A transmission, who have identified a mode of transmission, and who reported attack rates. Risk of bias will be appraised using an appropriate tool. Our results will be described narratively and where feasible and appropriate, a meta-analysis utilizing the random-effects model will be used to aggregate the incidence proportions (attack rates) for each mode of transmission. In addition, we will also evaluate the emm genotype variants of the M protein causing Strep A infection and the association with transmission routes and attack rates, if any, by setting, socioeconomic background and geographical regions. Discussion We anticipate that this review will contribute to elucidating Strep A modes of transmission which in turn, will serve to inform evidence-based strategies including environmental health activities to reduce the transmission of Strep A in populations at risk of severe disease. Trial registration Systematic review registration: PROSPERO ( CRD42019138472 ). DA - 2021-03-31 DB - OpenUCT DP - University of Cape Town IS - Article number: 90 J1 - Systematic Reviews KW - Group A Streptococcus KW - Transmission KW - Systematic review KW - Environmental health KW - Public health LK - https://open.uct.ac.za PY - 2021 T1 - Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis TI - Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis UR - http://hdl.handle.net/11427/35162 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s13643-021-01641-5
dc.identifier.urihttp://hdl.handle.net/11427/35162
dc.identifier.vancouvercitationBarth DD, Daw J, Xu R, Enkel S, Pickering J, McRae T, et al. Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis. Systematic Reviews. 2021;10(Article number: 90) http://hdl.handle.net/11427/35162.en_ZA
dc.language.isoenen_US
dc.language.rfc3066en
dc.publisher.departmentDepartment of Medicineen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceSystematic Reviewsen_US
dc.source.journalissueArticle number: 90en_US
dc.source.journalvolume10en_US
dc.source.urihttps://systematicreviewsjournal.biomedcentral.com/
dc.subjectGroup A Streptococcusen_US
dc.subjectTransmissionen_US
dc.subjectSystematic reviewen_US
dc.subjectEnvironmental healthen_US
dc.subjectPublic healthen_US
dc.titleModes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysisen_US
dc.typeJournal Articleen_US
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