Gastric remnant carcinoma : histochemical and immunohistochemical profile

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dc.contributor.advisorMall, Anwar Sen_ZA
dc.contributor.authorElazzabi, Tawfiken_ZA
dc.date.accessioned2014-07-28T14:51:31Z
dc.date.available2014-07-28T14:51:31Z
dc.date.issued2004en_ZA
dc.descriptionIncludes bibliographical references (leaves 52-65).
dc.description.abstractGastric remnant carcinoma (GRC) is a gastric cancer that develops in gastric remnant more than five years after resection for benign disease. GRC comprises 1 %-9% of all gastric cancers. Partial gastrectomy for peptic ulcer is thought to be a risk factor for GRC. Pancreato-duodenal and bile reflux may play an important part in the aetiology of GRC. Primary gastric carcinoma (pGC) is a gastric cancer that arises in un-operated stomach and chronic gastritis is a well-known risk factor. Consequently there appear to be differences in the aetiology of GRC and PGC. According to many studies, surgical treatment of early GRC (Stage I or II) resulted in the same or better prognosis with similar stage PGC. However if diagnosed late, GRC has a worse prognosis than PGC at the same stage. In this study haematoxylin and eosin, alcian blue pH 2.5, periodic acid Schiff, high iron diamine and Giemsa stains as well as immunohistochemical methods (eight antibodies against MUCI to MUC6) were used to determine the type of mucin and the pattern of staining in twenty cases of GRC and twenty PGC (ten cases of intestinal type PGC, ten diffuse type PGC) and ten normal gastric mucosal biopsies. The aim of the study was to describe the morphology of GRC and the adjacent gastric mucosa, as well as to determine the histochemical and immunohistochemical mucin profile of GRC and to compare this with that of PGC and normal mucosa.en_ZA
dc.identifier.apacitationElazzabi, T. (2004). <i>Gastric remnant carcinoma : histochemical and immunohistochemical profile</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Anatomical Pathology. Retrieved from http://hdl.handle.net/11427/3076en_ZA
dc.identifier.chicagocitationElazzabi, Tawfik. <i>"Gastric remnant carcinoma : histochemical and immunohistochemical profile."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Anatomical Pathology, 2004. http://hdl.handle.net/11427/3076en_ZA
dc.identifier.citationElazzabi, T. 2004. Gastric remnant carcinoma : histochemical and immunohistochemical profile. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Elazzabi, Tawfik AB - Gastric remnant carcinoma (GRC) is a gastric cancer that develops in gastric remnant more than five years after resection for benign disease. GRC comprises 1 %-9% of all gastric cancers. Partial gastrectomy for peptic ulcer is thought to be a risk factor for GRC. Pancreato-duodenal and bile reflux may play an important part in the aetiology of GRC. Primary gastric carcinoma (pGC) is a gastric cancer that arises in un-operated stomach and chronic gastritis is a well-known risk factor. Consequently there appear to be differences in the aetiology of GRC and PGC. According to many studies, surgical treatment of early GRC (Stage I or II) resulted in the same or better prognosis with similar stage PGC. However if diagnosed late, GRC has a worse prognosis than PGC at the same stage. In this study haematoxylin and eosin, alcian blue pH 2.5, periodic acid Schiff, high iron diamine and Giemsa stains as well as immunohistochemical methods (eight antibodies against MUCI to MUC6) were used to determine the type of mucin and the pattern of staining in twenty cases of GRC and twenty PGC (ten cases of intestinal type PGC, ten diffuse type PGC) and ten normal gastric mucosal biopsies. The aim of the study was to describe the morphology of GRC and the adjacent gastric mucosa, as well as to determine the histochemical and immunohistochemical mucin profile of GRC and to compare this with that of PGC and normal mucosa. DA - 2004 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2004 T1 - Gastric remnant carcinoma : histochemical and immunohistochemical profile TI - Gastric remnant carcinoma : histochemical and immunohistochemical profile UR - http://hdl.handle.net/11427/3076 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3076
dc.identifier.vancouvercitationElazzabi T. Gastric remnant carcinoma : histochemical and immunohistochemical profile. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Anatomical Pathology, 2004 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3076en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Anatomical Pathologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherAnatomical Pathologyen_ZA
dc.titleGastric remnant carcinoma : histochemical and immunohistochemical profileen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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