Human rhinovirus infection in young African children with acute wheezing

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dc.contributor.authorSmuts, Heidien_ZA
dc.contributor.authorWorkman, Lesleyen_ZA
dc.contributor.authorZar, Heatheren_ZA
dc.date.accessioned2015-10-28T06:45:36Z
dc.date.available2015-10-28T06:45:36Z
dc.date.issued2011en_ZA
dc.description.abstractBACKGROUND:Infections caused by human rhinoviruses (HRVs) are important triggers of wheezing in young children. Wheezy illness has increasingly been recognised as an important cause of morbidity in African children, but there is little information on the contribution of HRV to this. The aim of this study was to determine the role of HRV as a cause of acute wheezing in South African children. METHODS: Two hundred and twenty children presenting consecutively at a tertiary children's hospital with a wheezing illness from May 2004 to November 2005 were prospectively enrolled. A nasal swab was taken and reverse transcription PCR used to screen the samples for HRV. The presence of human metapneumovirus, human bocavirus and human coronavirus-NL63 was assessed in all samples using PCR-based assays. A general shell vial culture using a pool of monoclonal antibodies was used to detect other common respiratory viruses on 26% of samples. Phylogenetic analysis to determine circulating HRV species was performed on a portion of HRV-positive samples. Categorical characteristics were analysed using Fisher's Exact test. RESULTS: HRV was detected in 128 (58.2%) of children, most (72%) of whom were under 2 years of age. Presenting symptoms between the HRV-positive and negative groups were similar. Most illness was managed with ambulatory therapy, but 45 (35%) were hospitalized for treatment and 3 (2%) were admitted to intensive care. There were no in-hospital deaths. All 3 species of HRV were detected with HRV-C being the most common (52%) followed by HRV-A (37%) and HRV-B (11%). Infection with other respiratory viruses occurred in 20/128 (16%) of HRV-positive children and in 26/92 (28%) of HRV-negative samples. CONCLUSION: HRV may be the commonest viral infection in young South African children with acute wheezing. Infection is associated with mild or moderate clinical disease.en_ZA
dc.identifier.apacitationSmuts, H., Workman, L., & Zar, H. (2011). Human rhinovirus infection in young African children with acute wheezing. <i>BMC Infectious Diseases</i>, http://hdl.handle.net/11427/14423en_ZA
dc.identifier.chicagocitationSmuts, Heidi, Lesley Workman, and Heather Zar "Human rhinovirus infection in young African children with acute wheezing." <i>BMC Infectious Diseases</i> (2011) http://hdl.handle.net/11427/14423en_ZA
dc.identifier.citationSmuts, H. E., Workman, L. J., & Zar, H. J. (2011). Human rhinovirus infection in young African children with acute wheezing. BMC infectious diseases, 11(1), 65.en_ZA
dc.identifier.ris TY - Journal Article AU - Smuts, Heidi AU - Workman, Lesley AU - Zar, Heather AB - BACKGROUND:Infections caused by human rhinoviruses (HRVs) are important triggers of wheezing in young children. Wheezy illness has increasingly been recognised as an important cause of morbidity in African children, but there is little information on the contribution of HRV to this. The aim of this study was to determine the role of HRV as a cause of acute wheezing in South African children. METHODS: Two hundred and twenty children presenting consecutively at a tertiary children's hospital with a wheezing illness from May 2004 to November 2005 were prospectively enrolled. A nasal swab was taken and reverse transcription PCR used to screen the samples for HRV. The presence of human metapneumovirus, human bocavirus and human coronavirus-NL63 was assessed in all samples using PCR-based assays. A general shell vial culture using a pool of monoclonal antibodies was used to detect other common respiratory viruses on 26% of samples. Phylogenetic analysis to determine circulating HRV species was performed on a portion of HRV-positive samples. Categorical characteristics were analysed using Fisher's Exact test. RESULTS: HRV was detected in 128 (58.2%) of children, most (72%) of whom were under 2 years of age. Presenting symptoms between the HRV-positive and negative groups were similar. Most illness was managed with ambulatory therapy, but 45 (35%) were hospitalized for treatment and 3 (2%) were admitted to intensive care. There were no in-hospital deaths. All 3 species of HRV were detected with HRV-C being the most common (52%) followed by HRV-A (37%) and HRV-B (11%). Infection with other respiratory viruses occurred in 20/128 (16%) of HRV-positive children and in 26/92 (28%) of HRV-negative samples. CONCLUSION: HRV may be the commonest viral infection in young South African children with acute wheezing. Infection is associated with mild or moderate clinical disease. DA - 2011 DB - OpenUCT DO - 10.1186/1471-2334-11-65 DP - University of Cape Town J1 - BMC Infectious Diseases LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Human rhinovirus infection in young African children with acute wheezing TI - Human rhinovirus infection in young African children with acute wheezing UR - http://hdl.handle.net/11427/14423 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14423
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2334-11-65
dc.identifier.vancouvercitationSmuts H, Workman L, Zar H. Human rhinovirus infection in young African children with acute wheezing. BMC Infectious Diseases. 2011; http://hdl.handle.net/11427/14423.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Virologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2011 Smuts et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceBMC Infectious Diseasesen_ZA
dc.source.urihttp://www.biomedcentral.com/bmcinfectdis/en_ZA
dc.subject.otherHuman bocavirusen_ZA
dc.subject.otherMetapneumovirusen_ZA
dc.subject.otherPicornaviridae Infectionsen_ZA
dc.subject.otherPolymerase Chain Reactionen_ZA
dc.titleHuman rhinovirus infection in young African children with acute wheezingen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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