Heparanoid hydrogels for cardiovascular tissue regeneration

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dc.contributor.advisorBezuidenhout, Deonen_ZA
dc.contributor.advisorDavies, Neilen_ZA
dc.contributor.authorJanse van Rensburg, Alizaen_ZA
dc.date.accessioned2016-02-02T14:42:02Z
dc.date.available2016-02-02T14:42:02Z
dc.date.issued2015en_ZA
dc.descriptionIncludes bibliographical referencesen_ZA
dc.description.abstractHeparin (Hep) and heparan sulfate (HS) have been shown to possess anticoagulative properties, inhibit smooth muscle cell proliferation, moderate inflammation and control angiogenesis by stabilization and potentiation of growth factors (GF). These properties are potentially very useful for the treatment of cardiovascular diseases, especially when delivered as injectable hydrogels that can form in situ. This project focused on developing Hep and HS hydrogels for localized GF delivery. Hep and HS were acrylated, characterized and crosslinked with PEG tetra-thiols, either directly (10m% Hep/HS-Ac, Type 1) or by copolymerization with 20PEG8Ac or 20PEG8VS (4m% copolymer; 1.5% Hep/HS-Ac) to form degradable (Type 2D) or non-degradable (Type 2N) gels, respectively. Gelation times, viscoelasticity, swelling, mesh size, Hep/HS elution and activity, as well as GF incorporation and release were studied in vitro. Type 2D gels with covalently incorporated (CI) Hep and GFs were evaluated in vivo as ingrowth matrices in porous polyurethane (PU) scaffolds for healing response in a rat subcutaneous model.en_ZA
dc.identifier.apacitationJanse van Rensburg, A. (2015). <i>Heparanoid hydrogels for cardiovascular tissue regeneration</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Biomedical Engineering. Retrieved from http://hdl.handle.net/11427/16695en_ZA
dc.identifier.chicagocitationJanse van Rensburg, Aliza. <i>"Heparanoid hydrogels for cardiovascular tissue regeneration."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Biomedical Engineering, 2015. http://hdl.handle.net/11427/16695en_ZA
dc.identifier.citationJanse van Rensburg, A. 2015. Heparanoid hydrogels for cardiovascular tissue regeneration. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Janse van Rensburg, Aliza AB - Heparin (Hep) and heparan sulfate (HS) have been shown to possess anticoagulative properties, inhibit smooth muscle cell proliferation, moderate inflammation and control angiogenesis by stabilization and potentiation of growth factors (GF). These properties are potentially very useful for the treatment of cardiovascular diseases, especially when delivered as injectable hydrogels that can form in situ. This project focused on developing Hep and HS hydrogels for localized GF delivery. Hep and HS were acrylated, characterized and crosslinked with PEG tetra-thiols, either directly (10m% Hep/HS-Ac, Type 1) or by copolymerization with 20PEG8Ac or 20PEG8VS (4m% copolymer; 1.5% Hep/HS-Ac) to form degradable (Type 2D) or non-degradable (Type 2N) gels, respectively. Gelation times, viscoelasticity, swelling, mesh size, Hep/HS elution and activity, as well as GF incorporation and release were studied in vitro. Type 2D gels with covalently incorporated (CI) Hep and GFs were evaluated in vivo as ingrowth matrices in porous polyurethane (PU) scaffolds for healing response in a rat subcutaneous model. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Heparanoid hydrogels for cardiovascular tissue regeneration TI - Heparanoid hydrogels for cardiovascular tissue regeneration UR - http://hdl.handle.net/11427/16695 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16695
dc.identifier.vancouvercitationJanse van Rensburg A. Heparanoid hydrogels for cardiovascular tissue regeneration. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Biomedical Engineering, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/16695en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Biomedical Engineeringen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherBiomedical Engineeringen_ZA
dc.titleHeparanoid hydrogels for cardiovascular tissue regenerationen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMSc (Med)en_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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