Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy in sub-saharan africa: a scoping review

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dc.contributor.advisorHorn, Alan
dc.contributor.advisorPillay Shakti
dc.contributor.authorBuxton-Tetteh, Naa Akyere
dc.date.accessioned2025-07-03T13:02:58Z
dc.date.available2025-07-03T13:02:58Z
dc.date.issued2025
dc.date.updated2025-07-03T12:56:02Z
dc.description.abstractThere are divergent views regarding therapeutic hypothermia (TH) for neonatal hypoxic ischaemic encephalopathy (HIE) in low- and middle-income countries. The aim of this review was to synthesize the literature describing TH for HIE in sub-Saharan Africa by searching Pubmed, Scopus, Google Scholar, and Web of Science from 1996–2023. Thirty records were included: Three surveys, one feasibility study and 26 publications describing 21 cohorts, cooling 1420 babies in South Africa, Uganda, and Ghana. There were five studies recruiting at follow-up, five pilot studies, one randomised controlled trial, one case series, and 10 birth cohorts. Methods and design were highly variable and often inadequate. Two adequately described studies reported survival with normal/mildly abnormal outcome in 71% and 61%, and one representative study of clinic attenders showed 7% cerebral palsy in survivors. Loss to follow-up was 33–36%. Although outcomes were similar to global norms, the high loss to follow-up limits interpretation.
dc.identifier.apacitationBuxton-Tetteh, N. A. (2025). <i>Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy in sub-saharan africa: a scoping review</i>. (). University of Cape town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. Retrieved from http://hdl.handle.net/11427/41523en_ZA
dc.identifier.chicagocitationBuxton-Tetteh, Naa Akyere. <i>"Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy in sub-saharan africa: a scoping review."</i> ., University of Cape town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2025. http://hdl.handle.net/11427/41523en_ZA
dc.identifier.citationBuxton-Tetteh, N.A. 2025. Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy in sub-saharan africa: a scoping review. . University of Cape town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. http://hdl.handle.net/11427/41523en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Buxton-Tetteh, Naa Akyere AB - There are divergent views regarding therapeutic hypothermia (TH) for neonatal hypoxic ischaemic encephalopathy (HIE) in low- and middle-income countries. The aim of this review was to synthesize the literature describing TH for HIE in sub-Saharan Africa by searching Pubmed, Scopus, Google Scholar, and Web of Science from 1996–2023. Thirty records were included: Three surveys, one feasibility study and 26 publications describing 21 cohorts, cooling 1420 babies in South Africa, Uganda, and Ghana. There were five studies recruiting at follow-up, five pilot studies, one randomised controlled trial, one case series, and 10 birth cohorts. Methods and design were highly variable and often inadequate. Two adequately described studies reported survival with normal/mildly abnormal outcome in 71% and 61%, and one representative study of clinic attenders showed 7% cerebral palsy in survivors. Loss to follow-up was 33–36%. Although outcomes were similar to global norms, the high loss to follow-up limits interpretation. DA - 2025 DB - OpenUCT DP - University of Cape Town KW - Paediatrics and Child Health LK - https://open.uct.ac.za PB - University of Cape town PY - 2025 T1 - Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy in sub-saharan africa: a scoping review TI - Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy in sub-saharan africa: a scoping review UR - http://hdl.handle.net/11427/41523 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/41523
dc.identifier.vancouvercitationBuxton-Tetteh NA. Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy in sub-saharan africa: a scoping review. []. University of Cape town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2025 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/41523en_ZA
dc.language.rfc3066Eng
dc.publisher.departmentDepartment of Paediatrics and Child Health
dc.publisher.facultyFaculty of Health Sciences
dc.publisher.institutionUniversity of Cape town
dc.subjectPaediatrics and Child Health
dc.titleTherapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy in sub-saharan africa: a scoping review
dc.typeThesis / Dissertation
dc.type.qualificationlevelMasters
dc.type.qualificationlevelMMed
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