Isoniazid preventative therapy penetrance at a community health centre in South Africa: a cross sectional study
| dc.contributor.advisor | De Vries, Elsje Maria | |
| dc.contributor.author | Steyn, Johannes | |
| dc.date.accessioned | 2023-04-20T14:03:59Z | |
| dc.date.available | 2023-04-20T14:03:59Z | |
| dc.date.issued | 2022 | |
| dc.date.updated | 2023-04-20T14:01:29Z | |
| dc.description.abstract | Background: Tuberculosis (TB) remains a major contributor to morbidity and mortality in people living with HIV (PLHIV). The use of Isoniazid preventative therapy (IPT) has been proven to be effective and safe to reduce this burden. Despite overwhelming evidence, uptake op IPT is poor. This study evaluated an urban population of PLHIV and described associations with the delivery of IPT. Methods: A retrospective folder review. Results: A total of 198 folders were reviewed of which 31 had been/currently were on IPT. In the no-IPT group the fast majority, 86%, of the patients were eligible (according to current national HIV guidelines) for IPT. Only 4% had true contraindications. Factors favouring the delivery of IPT was the duration on ART (p=0.0038) and being part of the ART adherence club(AC) system (<0.0001). Conclusion: The vast majority of patients are screened but do not receive TPT. The duration of ART increased the likelihood of a patient to receive IPT. However, patients recently started on ART are at higher risk of TB disease and will benefit greatly from IPT. Patients who were enrolled in the AC system had a higher IPT penetrance. Quality improvement cycles should be implemented to address the situation. Increasing the role that adherence clubs play may be an option for future interventions. | |
| dc.identifier.apacitation | Steyn, J. (2022). <i>Isoniazid preventative therapy penetrance at a community health centre in South Africa: a cross sectional study</i>. (). ,Faculty of Health Sciences ,Department of Public Health and Family Medicine. Retrieved from http://hdl.handle.net/11427/37804 | en_ZA |
| dc.identifier.chicagocitation | Steyn, Johannes. <i>"Isoniazid preventative therapy penetrance at a community health centre in South Africa: a cross sectional study."</i> ., ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2022. http://hdl.handle.net/11427/37804 | en_ZA |
| dc.identifier.citation | Steyn, J. 2022. Isoniazid preventative therapy penetrance at a community health centre in South Africa: a cross sectional study. . ,Faculty of Health Sciences ,Department of Public Health and Family Medicine. http://hdl.handle.net/11427/37804 | en_ZA |
| dc.identifier.ris | TY - Master Thesis AU - Steyn, Johannes AB - Background: Tuberculosis (TB) remains a major contributor to morbidity and mortality in people living with HIV (PLHIV). The use of Isoniazid preventative therapy (IPT) has been proven to be effective and safe to reduce this burden. Despite overwhelming evidence, uptake op IPT is poor. This study evaluated an urban population of PLHIV and described associations with the delivery of IPT. Methods: A retrospective folder review. Results: A total of 198 folders were reviewed of which 31 had been/currently were on IPT. In the no-IPT group the fast majority, 86%, of the patients were eligible (according to current national HIV guidelines) for IPT. Only 4% had true contraindications. Factors favouring the delivery of IPT was the duration on ART (p=0.0038) and being part of the ART adherence club(AC) system (<0.0001). Conclusion: The vast majority of patients are screened but do not receive TPT. The duration of ART increased the likelihood of a patient to receive IPT. However, patients recently started on ART are at higher risk of TB disease and will benefit greatly from IPT. Patients who were enrolled in the AC system had a higher IPT penetrance. Quality improvement cycles should be implemented to address the situation. Increasing the role that adherence clubs play may be an option for future interventions. DA - 2022 DB - OpenUCT DP - University of Cape Town KW - family medicine LK - https://open.uct.ac.za PY - 2022 T1 - Isoniazid preventative therapy penetrance at a community health centre in South Africa: a cross sectional study TI - Isoniazid preventative therapy penetrance at a community health centre in South Africa: a cross sectional study UR - http://hdl.handle.net/11427/37804 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/37804 | |
| dc.identifier.vancouvercitation | Steyn J. Isoniazid preventative therapy penetrance at a community health centre in South Africa: a cross sectional study. []. ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2022 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/37804 | en_ZA |
| dc.language.rfc3066 | eng | |
| dc.publisher.department | Department of Public Health and Family Medicine | |
| dc.publisher.faculty | Faculty of Health Sciences | |
| dc.subject | family medicine | |
| dc.title | Isoniazid preventative therapy penetrance at a community health centre in South Africa: a cross sectional study | |
| dc.type | Master Thesis | |
| dc.type.qualificationlevel | Masters | |
| dc.type.qualificationlevel | MMed |