Human T cell lymphotropic virus type 1- associated infective dermatitis in KwaZulu Natal, South Africa

dc.contributor.authorHlela, Carolen_ZA
dc.contributor.authorGraham, Natalieen_ZA
dc.contributor.authorBhigjee, Ahmeden_ZA
dc.contributor.authorTaylor, Grahamen_ZA
dc.contributor.authorKhumalo, Nonhlanhlaen_ZA
dc.contributor.authorMosam, Anisaen_ZA
dc.date.accessioned2015-11-23T11:39:27Z
dc.date.available2015-11-23T11:39:27Z
dc.date.issued2013en_ZA
dc.description.abstractBACKGROUND: The Human T cell lymphotropic virus type 1 (HTLV-1)-associated infective dermatitis (IDH), is a chronic relapsing dermatitis which usually presents in children older than 2years. A total of 300 cases have been reported worldwide (Latin America, the Caribbean and only 5 from Senegal). Neither IDH, nor its complications have been reported from the rest of Africa. We aimed to examine the clinical and aetiological characteristics of IDH in a cohort of South African children. METHODS: Attendees at the dermatology clinic at King Edward VIII Hospital, Durban underwent clinical examination. After obtaining consent those suspected of IDH had specimens taken for blood counts, immunoglobulins, serum protein electrophoresis, viral studies (including genotyping), skin swabs and stool examinations. RESULTS: Nineteen of 60 suspected cases recruited over 3years met the diagnostic criteria for IDH. The male-to-female ratio was 1:2; mean age 8years (range 0.7 to 15). Dermatitis mostly affected the scalp (78.9%) and axilla (73.7%); fewer children had nasal crusting (47.4%). Mean Ig A, IgG and IgM were raised, at 3.52g/l, 22.6g/l and 1.38g/l, respectively. The median CD4 cell count was 1958 cells/mm3. Viral genotyping of all tested samples were positive for the Cosmopolitan, Subtype A (HTLV-1a). CONCLUSIONS: IDH is a distinct entity which also affects South Africans. Our patients were older at presentation and the majority did not present with nasal crusting as has been described in other countries.en_ZA
dc.identifier.apacitationHlela, C., Graham, N., Bhigjee, A., Taylor, G., Khumalo, N., & Mosam, A. (2013). Human T cell lymphotropic virus type 1- associated infective dermatitis in KwaZulu Natal, South Africa. <i>BMC Dermatology</i>, http://hdl.handle.net/11427/15227en_ZA
dc.identifier.chicagocitationHlela, Carol, Natalie Graham, Ahmed Bhigjee, Graham Taylor, Nonhlanhla Khumalo, and Anisa Mosam "Human T cell lymphotropic virus type 1- associated infective dermatitis in KwaZulu Natal, South Africa." <i>BMC Dermatology</i> (2013) http://hdl.handle.net/11427/15227en_ZA
dc.identifier.citationHlela, C., Graham, N., Bhigjee, A. I., Taylor, G. P., Khumalo, N. P., & Mosam, A. (2013). Human T cell lymphotropic virus type 1-associated infective dermatitis in KwaZulu Natal, South Africa. BMC dermatology, 13(1), 11.en_ZA
dc.identifier.ris TY - Journal Article AU - Hlela, Carol AU - Graham, Natalie AU - Bhigjee, Ahmed AU - Taylor, Graham AU - Khumalo, Nonhlanhla AU - Mosam, Anisa AB - BACKGROUND: The Human T cell lymphotropic virus type 1 (HTLV-1)-associated infective dermatitis (IDH), is a chronic relapsing dermatitis which usually presents in children older than 2years. A total of 300 cases have been reported worldwide (Latin America, the Caribbean and only 5 from Senegal). Neither IDH, nor its complications have been reported from the rest of Africa. We aimed to examine the clinical and aetiological characteristics of IDH in a cohort of South African children. METHODS: Attendees at the dermatology clinic at King Edward VIII Hospital, Durban underwent clinical examination. After obtaining consent those suspected of IDH had specimens taken for blood counts, immunoglobulins, serum protein electrophoresis, viral studies (including genotyping), skin swabs and stool examinations. RESULTS: Nineteen of 60 suspected cases recruited over 3years met the diagnostic criteria for IDH. The male-to-female ratio was 1:2; mean age 8years (range 0.7 to 15). Dermatitis mostly affected the scalp (78.9%) and axilla (73.7%); fewer children had nasal crusting (47.4%). Mean Ig A, IgG and IgM were raised, at 3.52g/l, 22.6g/l and 1.38g/l, respectively. The median CD4 cell count was 1958 cells/mm3. Viral genotyping of all tested samples were positive for the Cosmopolitan, Subtype A (HTLV-1a). CONCLUSIONS: IDH is a distinct entity which also affects South Africans. Our patients were older at presentation and the majority did not present with nasal crusting as has been described in other countries. DA - 2013 DB - OpenUCT DO - 10.1186/1471-5945-13-11 DP - University of Cape Town J1 - BMC Dermatology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Human T cell lymphotropic virus type 1- associated infective dermatitis in KwaZulu Natal, South Africa TI - Human T cell lymphotropic virus type 1- associated infective dermatitis in KwaZulu Natal, South Africa UR - http://hdl.handle.net/11427/15227 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15227
dc.identifier.urihttp://dx.doi.org/10.1186/1471-5945-13-11
dc.identifier.vancouvercitationHlela C, Graham N, Bhigjee A, Taylor G, Khumalo N, Mosam A. Human T cell lymphotropic virus type 1- associated infective dermatitis in KwaZulu Natal, South Africa. BMC Dermatology. 2013; http://hdl.handle.net/11427/15227.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Dermatologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2013 Hlela et al.; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceBMC Dermatologyen_ZA
dc.source.urihttp://www.biomedcentral.com/bmcdermatol/en_ZA
dc.subject.otherHuman T cell lymphotropic virus type 1 (HTLV-1)en_ZA
dc.subject.otherinfective dermatitis (IDH)en_ZA
dc.titleHuman T cell lymphotropic virus type 1- associated infective dermatitis in KwaZulu Natal, South Africaen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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