The agreement between cervical abnormalities identified by cytology and detection of high-risk types of human papillomavirus
| dc.contributor.author | Allan, Bruce R | |
| dc.contributor.author | Marais, Dianne J | |
| dc.contributor.author | Denny, Lynette | |
| dc.contributor.author | Hoffman, Margaret | |
| dc.contributor.author | Shapiro, Samuel | |
| dc.contributor.author | Williamson, Anna-Lise | |
| dc.date.accessioned | 2017-05-17T10:19:24Z | |
| dc.date.available | 2017-05-17T10:19:24Z | |
| dc.date.issued | 2006 | |
| dc.date.updated | 2016-01-08T08:28:13Z | |
| dc.description.abstract | Objectives and design. Human papillomavirus (HPV) is causally associated with cervical cancer. Using the Digene Hybrid Capture 2 high-risk HPV test (HC2), we investigated the prevalence of high-risk HPV in cervical specimens, and compared results with those of Papanicolaou (Pap) smears taken concurrently Subjects and setting. Cervical specimens were obtained from women attending hospitals/community health centres in the Western Cape province of South Africa. They were participating in a case-control study of the association of hormonal contraceptives and invasive cervical cancer. Results. Of 1 491 women tested, 254 (17%) were HPV DNA positive. The age-specific prevalence of HPV was 36/97 (37.1%) in those aged < 30 years, 78/369 (21.1%) in those aged 30 - 39 years, 78/603 (12.9%) in those aged 40 - 49 years and 62/422 (14.7%) in those aged 50 - 59 years. In women with normal cytology the prevalence of HPV was 10.9% (138/1 264); in those with abnormal squamous cells of unknown significance (AS-CUS) it was 30.8% (36/117); in those with low-grade squamous intraepithelial lesions (LSIL) it was 63.2% (36/57), and in those with high-grade squamous intraepithelial lesions (HSIL) it was 83% (44/53). The odds ratio between HPV and HSIL in women aged 40 - 59 years was 57.1 (confidence interval 22.4 - 170.7). Conclusions. HC2 detected a high prevalence of HPV (17%) in this population. Most women with HSIL (83%) were positive, indicating that HPV testing of AS-CUS women may aid in management. When costs decrease, HC2 could be introduced as an adjunct to Pap smears in identifying women at risk for high-grade cervical disease and could be useful in the maintenance of cervical health in those who remain Pap smear negative. | |
| dc.identifier | http://dx.doi.org/10.7196/SAMJ.1344 | |
| dc.identifier.apacitation | Allan, B. R., Marais, D. J., Denny, L., Hoffman, M., Shapiro, S., & Williamson, A. (2006). The agreement between cervical abnormalities identified by cytology and detection of high-risk types of human papillomavirus. <i>South African Medical Journal</i>, http://hdl.handle.net/11427/24347 | en_ZA |
| dc.identifier.chicagocitation | Allan, Bruce R, Dianne J Marais, Lynette Denny, Margaret Hoffman, Samuel Shapiro, and Anna-Lise Williamson "The agreement between cervical abnormalities identified by cytology and detection of high-risk types of human papillomavirus." <i>South African Medical Journal</i> (2006) http://hdl.handle.net/11427/24347 | en_ZA |
| dc.identifier.citation | Allan, B., Marais, D., Denny, L., Hoffman, M., Shapiro, S., & Williamson, A. (2008). The agreement between cervical abnormalities identified by cytology and detection of high-risk types of human papillomavirus. South African Medical Journal, 96(11), 1186. | |
| dc.identifier.ris | TY - Journal Article AU - Allan, Bruce R AU - Marais, Dianne J AU - Denny, Lynette AU - Hoffman, Margaret AU - Shapiro, Samuel AU - Williamson, Anna-Lise AB - Objectives and design. Human papillomavirus (HPV) is causally associated with cervical cancer. Using the Digene Hybrid Capture 2 high-risk HPV test (HC2), we investigated the prevalence of high-risk HPV in cervical specimens, and compared results with those of Papanicolaou (Pap) smears taken concurrently Subjects and setting. Cervical specimens were obtained from women attending hospitals/community health centres in the Western Cape province of South Africa. They were participating in a case-control study of the association of hormonal contraceptives and invasive cervical cancer. Results. Of 1 491 women tested, 254 (17%) were HPV DNA positive. The age-specific prevalence of HPV was 36/97 (37.1%) in those aged < 30 years, 78/369 (21.1%) in those aged 30 - 39 years, 78/603 (12.9%) in those aged 40 - 49 years and 62/422 (14.7%) in those aged 50 - 59 years. In women with normal cytology the prevalence of HPV was 10.9% (138/1 264); in those with abnormal squamous cells of unknown significance (AS-CUS) it was 30.8% (36/117); in those with low-grade squamous intraepithelial lesions (LSIL) it was 63.2% (36/57), and in those with high-grade squamous intraepithelial lesions (HSIL) it was 83% (44/53). The odds ratio between HPV and HSIL in women aged 40 - 59 years was 57.1 (confidence interval 22.4 - 170.7). Conclusions. HC2 detected a high prevalence of HPV (17%) in this population. Most women with HSIL (83%) were positive, indicating that HPV testing of AS-CUS women may aid in management. When costs decrease, HC2 could be introduced as an adjunct to Pap smears in identifying women at risk for high-grade cervical disease and could be useful in the maintenance of cervical health in those who remain Pap smear negative. DA - 2006 DB - OpenUCT DP - University of Cape Town J1 - South African Medical Journal LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - The agreement between cervical abnormalities identified by cytology and detection of high-risk types of human papillomavirus TI - The agreement between cervical abnormalities identified by cytology and detection of high-risk types of human papillomavirus UR - http://hdl.handle.net/11427/24347 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/24347 | |
| dc.identifier.vancouvercitation | Allan BR, Marais DJ, Denny L, Hoffman M, Shapiro S, Williamson A. The agreement between cervical abnormalities identified by cytology and detection of high-risk types of human papillomavirus. South African Medical Journal. 2006; http://hdl.handle.net/11427/24347. | en_ZA |
| dc.language.iso | eng | |
| dc.publisher.department | Institute of Infectious Disease and Molecular Medicine | en_ZA |
| dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.source | South African Medical Journal | |
| dc.source.uri | http://www.samj.org.za/index.php/samj | |
| dc.subject.other | High-risk human papillomavirus | |
| dc.subject.other | Prevalence | |
| dc.subject.other | Cervical specimens | |
| dc.subject.other | Pap smears | |
| dc.subject.other | Cervical cancer | |
| dc.title | The agreement between cervical abnormalities identified by cytology and detection of high-risk types of human papillomavirus | |
| dc.type | Journal Article | en_ZA |
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Article | en_ZA |