Chylomicron remnant metabolism in familial dyslipidemias studied with a remnant-like emulsion breath test

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dc.date.accessioned2021-10-08T07:22:53Z
dc.date.available2021-10-08T07:22:53Z
dc.date.issued2001
dc.description.abstractWe have developed a stable isotope breath test for the assessment of chylomicron remnant metabolism and report the results from the breath test in human subjects selected for disorders of chylomicron or remnant metabolism. In type I hyperlipemia, the phenotype is extreme hypertriglyceridemia due to a lack of lipoprotein lipase activity, which causes the failure of remnant formation. The type III dyslipidemia phenotype is caused by the inefficient removal of chylomicron remnants from plasma, generally because of homozygosity for apolipoprotein E2 alleles. The breath test was predicted to be abnormal in type III hyperlipemia, whereas a priori in type I hyperlipemia defective remnant clearance was not anticipated. Subjects were injected with lipid emulsions prepared with a composition similar to normal chylomicron remnants. The emulsions contained cholesteryl ester incorporating the stable nonradioactive isotope
dc.identifier.issn0022-2275
dc.identifier.issn1539-7262
dc.identifier.ris TY - Journal Article AB - We have developed a stable isotope breath test for the assessment of chylomicron remnant metabolism and report the results from the breath test in human subjects selected for disorders of chylomicron or remnant metabolism. In type I hyperlipemia, the phenotype is extreme hypertriglyceridemia due to a lack of lipoprotein lipase activity, which causes the failure of remnant formation. The type III dyslipidemia phenotype is caused by the inefficient removal of chylomicron remnants from plasma, generally because of homozygosity for apolipoprotein E2 alleles. The breath test was predicted to be abnormal in type III hyperlipemia, whereas a priori in type I hyperlipemia defective remnant clearance was not anticipated. Subjects were injected with lipid emulsions prepared with a composition similar to normal chylomicron remnants. The emulsions contained cholesteryl ester incorporating the stable nonradioactive isotope DA - 2001 DB - OpenUCT DP - University of Cape Town IS - 5 J1 - The Journal of Lipid Research LK - https://open.uct.ac.za PY - 2001 SM - 0022-2275 SM - 1539-7262 T1 - Chylomicron remnant metabolism in familial dyslipidemias studied with a remnant-like emulsion breath test TI - Chylomicron remnant metabolism in familial dyslipidemias studied with a remnant-like emulsion breath test UR - http://hdl.handle.net/11427/35020 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/35020
dc.language.isoeng
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceThe Journal of Lipid Research
dc.source.journalissue5
dc.source.journalvolume42
dc.source.pagination710 - 715
dc.source.urihttps://dx.doi.org/10.7196/sajs.718
dc.subject.otherAdolescent
dc.subject.otherAdult
dc.subject.otherApolipoprotein B-48
dc.subject.otherApolipoproteins B
dc.subject.otherBreath Tests
dc.subject.otherCarbon Dioxide
dc.subject.otherCarbon Radioisotopes
dc.subject.otherChild
dc.subject.otherCholesterol
dc.subject.otherCholesterol, HDL
dc.subject.otherCholesterol, VLDL
dc.subject.otherChylomicron Remnants
dc.subject.otherChylomicrons
dc.subject.otherEmulsions
dc.subject.otherFemale
dc.subject.otherHumans
dc.titleChylomicron remnant metabolism in familial dyslipidemias studied with a remnant-like emulsion breath test
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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