Recombination patterns in aphthoviruses mirror those found in other picornaviruses
| dc.contributor.author | Heath, Livio | |
| dc.contributor.author | van der Walt, Eric | |
| dc.contributor.author | Varsani, Arvind | |
| dc.contributor.author | Martin, Darren P | |
| dc.date.accessioned | 2016-07-30T19:26:58Z | |
| dc.date.available | 2016-07-30T19:26:58Z | |
| dc.date.issued | 2006 | |
| dc.date.updated | 2016-07-29T14:18:10Z | |
| dc.description.abstract | Foot-and-mouth disease virus (FMDV) is thought to evolve largely through genetic drift driven by the inherently error-prone nature of its RNA polymerase. There is, however, increasing evidence that recombination is an important mechanism in the evolution of these and other related picornoviruses. Here, we use an extensive set of recombination detection methods to identify 86 unique potential recombination events among 125 publicly available FMDV complete genome sequences. The large number of events detected between members of different serotypes suggests that horizontal flow of sequences among the serotypes is relatively common and does not incur severe fitness costs. Interestingly, the distribution of recombination breakpoints was found to be largely nonrandom. Whereas there are clear breakpoint cold spots within the structural genes, two statistically significant hot spots precisely separate these from the nonstructural genes. Very similar breakpoint distributions were found for other picornovirus species in the genera Enterovirus and Teschovirus. Our results suggest that genome regions encoding the structural proteins of both FMDV and other picornaviruses are functionally interchangeable modules, supporting recent proposals that the structural and nonstructural coding regions of the picornaviruses are evolving largely independently of one another. | en_ZA |
| dc.identifier | http://dx.doi.org/10.1128/JVI.01100-06 | |
| dc.identifier.apacitation | Heath, L., van der Walt, E., Varsani, A., & Martin, D. P. (2006). Recombination patterns in aphthoviruses mirror those found in other picornaviruses. <i>Journal of Virology</i>, http://hdl.handle.net/11427/21076 | en_ZA |
| dc.identifier.chicagocitation | Heath, Livio, Eric van der Walt, Arvind Varsani, and Darren P Martin "Recombination patterns in aphthoviruses mirror those found in other picornaviruses." <i>Journal of Virology</i> (2006) http://hdl.handle.net/11427/21076 | en_ZA |
| dc.identifier.citation | Heath, L., van der Walt, E., Varsani, A., & Martin, D. P. (2006). Recombination patterns in aphthoviruses mirror those found in other picornaviruses. Journal of Virology, 80(23), 11827-11832. | en_ZA |
| dc.identifier.issn | 0022-538X | en_ZA |
| dc.identifier.ris | TY - Journal Article AU - Heath, Livio AU - van der Walt, Eric AU - Varsani, Arvind AU - Martin, Darren P AB - Foot-and-mouth disease virus (FMDV) is thought to evolve largely through genetic drift driven by the inherently error-prone nature of its RNA polymerase. There is, however, increasing evidence that recombination is an important mechanism in the evolution of these and other related picornoviruses. Here, we use an extensive set of recombination detection methods to identify 86 unique potential recombination events among 125 publicly available FMDV complete genome sequences. The large number of events detected between members of different serotypes suggests that horizontal flow of sequences among the serotypes is relatively common and does not incur severe fitness costs. Interestingly, the distribution of recombination breakpoints was found to be largely nonrandom. Whereas there are clear breakpoint cold spots within the structural genes, two statistically significant hot spots precisely separate these from the nonstructural genes. Very similar breakpoint distributions were found for other picornovirus species in the genera Enterovirus and Teschovirus. Our results suggest that genome regions encoding the structural proteins of both FMDV and other picornaviruses are functionally interchangeable modules, supporting recent proposals that the structural and nonstructural coding regions of the picornaviruses are evolving largely independently of one another. DA - 2006 DB - OpenUCT DP - University of Cape Town J1 - Journal of Virology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 SM - 0022-538X T1 - Recombination patterns in aphthoviruses mirror those found in other picornaviruses TI - Recombination patterns in aphthoviruses mirror those found in other picornaviruses UR - http://hdl.handle.net/11427/21076 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/21076 | |
| dc.identifier.vancouvercitation | Heath L, van der Walt E, Varsani A, Martin DP. Recombination patterns in aphthoviruses mirror those found in other picornaviruses. Journal of Virology. 2006; http://hdl.handle.net/11427/21076. | en_ZA |
| dc.language | eng | en_ZA |
| dc.publisher | American Society for Microbiology | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.source | Journal of Virology | en_ZA |
| dc.source.uri | http://jvi.asm.org/ | |
| dc.title | Recombination patterns in aphthoviruses mirror those found in other picornaviruses | en_ZA |
| dc.type | Journal Article | en_ZA |
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Article | en_ZA |